• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prediction of tumor dose uncertainties for motion tracking radiotherapy

Research Project

Project/Area Number 17K15802
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionOsaka University

Principal Investigator

Akino Yuichi  大阪大学, 医学系研究科, 特任助教(常勤) (00722323)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords動体追尾照射 / サイバーナイフ / 呼吸性移動 / 小照射野 / 放射線治療 / 臓器位置不確定性 / 線量不確定性 / 体幹部定位照射
Outline of Final Research Achievements

Stereotactic radiotherapy with respiratory motion tracking has been used for lung and liver tumors. In this study, we evaluated the tracking accuracy for cases with the respiratory phase shifts between the tumor and the chest wall. We also developed a method to evaluate the effect of the tracking error caused by the phase shifts on the dose distribution. We demonstrated that the tracking errors can occur in patients with phase shifts, but that the accuracy can be improved by slow breathing. In addition, we developed a method to evaluate the isocenter localization with submillimeter accuracy, and a film analysis method for patient specific quality assurance. In addition, we conducted surveys for multiple institutions to investigate the variations in small field dosimetry and high-precision radiotherapy in Japan.

Academic Significance and Societal Importance of the Research Achievements

治療計画の時点で患者の腫瘍と胸壁が同様に動いているか解析するのは困難であり、その影響を予測するのは難しい。本研究では治療前に追尾誤差やその線量分布への影響を評価する方法を開発した。この技術を用いることにより、追尾誤差が大きいと予想される患者には呼吸をゆっくりするようコーチングすることで追尾精度の改善が期待できる。また定位放射線治療で重要な小照射野の計測結果が国内で大きくばらついており、それは検出器の選択による影響が大きいことを明らかにした。適切な補正を行うことにより、国内の施設間における患者への投与線量のばらつきを小さくできると考えられる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (30 results)

All 2021 2020 2019 2018

All Journal Article (19 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 11 results) Presentation (11 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Technical Note: Characteristics of a microSilicon X shielded diode detector for photon beam dosimetry2021

    • Author(s)
      Akino Yuichi、Okamura Keita、Das Indra J.、Isohashi Fumiaki、Seo Yuji、Tamari Keisuke、Hirata Takero、Hayashi Kazuhiko、Inoue Shinichi、Ogawa Kazuhiko
    • Journal Title

      Medical Physics

      Volume: 48 Issue: 4 Pages: 2004-2009

    • DOI

      10.1002/mp.14639

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of raster scanning IMRT using a robotic radiosurgery system2021

    • Author(s)
      Shiomi Hiroya、Akino Yuichi、Sumida Iori、Masai Norihisa、Oh Ryoong-Jin、Ogawa Kazuhiko
    • Journal Title

      Journal of Radiation Research

      Volume: 62 Issue: 2 Pages: 364-373

    • DOI

      10.1093/jrr/rraa136

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correction of lateral response artifacts from flatbed scanners for dual-channel radiochromic film dosimetry2021

    • Author(s)
      Akino Yuichi、Shiomi Hiroya、Isohashi Fumiaki、Suzuki Osamu、Seo Yuji、Tamari Keisuke、Hirata Takero、Mizuno Hirokazu、Ogawa Kazuhiko
    • Journal Title

      Journal of Radiation Research

      Volume: 62 Issue: 2 Pages: 319-328

    • DOI

      10.1093/jrr/rraa124

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a microSilicon diode detector for small-field photon beam dosimetry2020

    • Author(s)
      Akino Yuichi、Fujiwara Masateru、Okamura Keita、Shiomi Hiroya、Mizuno Hirokazu、Isohashi Fumiaki、Suzuki Osamu、Seo Yuji、Tamari Keisuke、Ogawa Kazuhiko
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 3 Pages: 410-418

    • DOI

      10.1093/jrr/rraa010

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the Differences Between Measurements in Multiple Institutions and Calculation Modeled by Representative Beam Data in Prostate VMAT Plan2020

    • Author(s)
      Hironao Goto
    • Journal Title

      in vivo

      Volume: 34 Issue: 3 Pages: 1503-1509

    • DOI

      10.21873/invivo.11937

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Repositioning accuracy of a novel thermoplastic mask for head and neck cancer radiotherapy2020

    • Author(s)
      Fukao Mari、Okamura Keita、Sabu Shotaro、Akino Yuichi、Arimura Takehiro、Inoue Shinichi、Kado Ryoko、Seo Yuji
    • Journal Title

      Physica Medica

      Volume: 74 Pages: 92-99

    • DOI

      10.1016/j.ejmp.2020.05.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collection and analysis of photon beam data for Varian C-series linear accelerators: a potential reference beam data set2020

    • Author(s)
      Tanaka Yoshihiro、Mizuno Hirokazu、Akino Yuichi、Isono Masaru、Masai Norihisa、Uta Erika、Yamamoto Toshijiro
    • Journal Title

      Physical and Engineering Sciences in Medicine

      Volume: 43 Issue: 3 Pages: 889-901

    • DOI

      10.1007/s13246-020-00885-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Commissioning of total body irradiation using plastic bead bags2020

    • Author(s)
      Akino Yuichi、Maruoka Shintaro、Yano Katsuyuki、Abe Hiroshi、Isohashi Fumiaki、Seo Yuji、Tamari Keisuke、Hirata Takero、Kawakami Manabu、Nakae Yoshiki、Tanaka Yoshihiro、Ogawa Kazuhiko
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 6 Pages: 959-968

    • DOI

      10.1093/jrr/rraa072

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deep learning-based virtual noncontrast CT for volumetric modulated arc therapy planning: Comparison with a dual-energy CT-based approach2020

    • Author(s)
      Koike Y, Ohira S, Akino Y, Sagawa T, Yagi M, Ueda Y, Miyazaki M, Sumida I, Teshima T, Ogawa K
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 2 Pages: 371-379

    • DOI

      10.1002/mp.13925

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of detector selections on inter-institutional variability of flattening filter-free beam data for TrueBeam linear accelerators2020

    • Author(s)
      Tanaka Y, Akino Y, Mizuno H, Isono M, Masai N, Yamamoto T
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 1 Pages: 36-42

    • DOI

      10.1002/acm2.12766

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small-field dosimetry of TrueBeamTM flattened and flattening filter-free beams: A multi-institutional analysis2020

    • Author(s)
      Akino Y, Mizuno H, Isono M, Tanaka Y, Masai N, Yamamoto T
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 1 Pages: 78-87

    • DOI

      10.1002/acm2.12791

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of synthetic computed tomography generated with an adversarial network for multi-sequence magnetic resonance-based brain radiotherapy2020

    • Author(s)
      Koike Y, Akino Y, Sumida I, Shiomi H, Mizuno H, Yagi M, Isohashi F, Seo Y, Suzuki O, Ogawa K
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 1 Pages: 92-103

    • DOI

      10.1093/jrr/rrz063

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inter-unit variability of multi-leaf collimator parameters for IMRT and VMAT treatment planning: a multi-institutional survey2020

    • Author(s)
      Isono M, Akino Y, Mizuno H, Tanaka Y, Masai N, Yamamoto T
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 2 Pages: 307-313

    • DOI

      10.1093/jrr/rrz082

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impacts of respiratory phase shifts on motion‐tracking accuracy of the CyberKnife Synchrony ? Respiratory Tracking System2019

    • Author(s)
      Akino Yuichi、Shiomi Hiroya、Sumida Iori、Isohashi Fumiaki、Seo Yuji、Suzuki Osamu、Tamari Keisuke、Otani Keisuke、Higashinaka Naokazu、Hayashida Miori、Mabuchi Nobuhisa、Ogawa Kazuhiko
    • Journal Title

      Medical Physics

      Volume: in press Issue: 9 Pages: 3757-3766

    • DOI

      10.1002/mp.13523

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of virtual starshot analysis providing submillimeter radiation isocenter accuracy: A long-term multi-institutional analysis2019

    • Author(s)
      Akino Y, Fujiwara M, Mizuno H, Shiomi H, Kaneko A, Isohashi F, Seo Y, Suzuki O, Otani K, Tamari K, Ogawa K
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 20 Issue: 10 Pages: 74-83

    • DOI

      10.1002/acm2.12715

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modalities and techniques used for stereotactic radiotherapy, intensity-modulated radiotherapy, and image-guided radiotherapy: A 2018 survey by the Japan Society of Medical Physics2019

    • Author(s)
      Akino Y, Tohyama N, Akino K, Ishikawa M, Kawamorita R, Kurooka M, Sumida I, Nakaguchi Y, Miyaura K, Nakamura M
    • Journal Title

      Physica Medica

      Volume: 64 Pages: 182-187

    • DOI

      10.1016/j.ejmp.2019.07.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the accuracy of the CyberKnife Synchrony? Respiratory Tracking System using a plastic scintillator2018

    • Author(s)
      Akino Yuichi、Sumida Iori、Shiomi Hiroya、Higashinaka Naokazu、Murashima Yoshiichi、Hayashida Miori、Mabuchi Nobuhisa、Ogawa Kazuhiko
    • Journal Title

      Medical Physics

      Volume: 45 Issue: 8 Pages: 3506-3515

    • DOI

      10.1002/mp.13028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inter-institutional variability of small-field-dosimetry beams among HD120? multileaf collimators: a multi-institutional analysis2018

    • Author(s)
      Akino Yuichi、Mizuno Hirokazu、Tanaka Yoshihiro、Isono Masaru、Masai Norihisa、Yamamoto Toshijiro
    • Journal Title

      Physics in Medicine & Biology

      Volume: 63 Issue: 20 Pages: 205018-205018

    • DOI

      10.1088/1361-6560/aae450

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] An effective method to reduce the interplay effects between respiratory motion and a uniform scanning proton beam irradiation for liver tumors: A case study2018

    • Author(s)
      Akino Yuichi、Wu Huanmei、Oh Ryoong‐Jin、Das Indra J.
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 20 Issue: 1 Pages: 220-228

    • DOI

      10.1002/acm2.12508

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Characterization of microSilicon diode detector for electron beam dosimetry2020

    • Author(s)
      Yuichi Akino, Masateru Fujiwara, Akari Kaneko, Takashi Masutani, Hirokazu Mizuno, Fumiaki Isohashi, Osamu Suzuki, Yuji Seo, Keisuke Tamari, Kazuhiko Ogawa
    • Organizer
      第119回 日本医学物理学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of respiratory phase shifts between lung tumor and external marker motions using a 320-slice dynamic volume 4D-CT2020

    • Author(s)
      Yuichi Akino, Osamu Suzuki, Hiroya Shiomi, Fumiaki Isohashi, Yuji Seo, Keisuke Tamari, Takero Hirata, Kazuhiko Ogawa
    • Organizer
      2020 Joint AAPM COMP Meeting
    • Related Report
      2020 Annual Research Report
  • [Presentation] プラスチックシンチレータ Exradin W2 を用いたサイバーナイフ小照射野の評価2020

    • Author(s)
      秋野祐一, 岡村啓太, 藤原聖輝, 塩見浩也, 井ノ上信一, 礒橋文明, 鈴木修, 瀬尾雄二, 玉利慶介, 平田岳郎, 小川和彦
    • Organizer
      第33回高精度放射線外部照射部会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Small field photon beam dosimetry of TrueBeam linear accelerators: a multi-institutional analysis2019

    • Author(s)
      Akino Y, Mizuno H, Isono M, Tanaka Y, Masai N, Yamamoto T
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Long term analysis of radiation isocenter accuracy using virtual starshot technique2019

    • Author(s)
      秋野祐一, 藤原聖輝, 水野裕一, 塩見浩也, 金子暁里, 礒橋文明, 瀬尾雄二, 鈴木修, 大谷啓祐, 玉利慶介, 小川和彦
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] microSiliconダイオード検出器の小照射野X線計測特性2019

    • Author(s)
      秋野祐一, 岡村啓太, 藤原聖輝, 塩見浩也, 水野裕一, 礒橋文明, 鈴木修, 瀬尾雄二, 玉利慶介, 小川和彦
    • Organizer
      第32回日本放射線腫瘍学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Deep learning-based virtual non-contrast CT for treatment planning : Comparison with dual-energy CT-based approach2019

    • Author(s)
      Koike Y, Ohira S, Akino Y, Ueda Y, Miyazaki M, Sumida I, Teshima T, Ogawa K
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Feasibility of synthetic CT generated from multi-sequence MR images using an adversarial network for MR-only radiotherapy2019

    • Author(s)
      Koike Y, Akino Y, Sumida I, Shiomi H, Mizuno H, Yagi M, Isohashi F, Seo Y, Suzuki O, Ogawa K
    • Organizer
      61th Annual Meeting and Exhibition, American Association of Physicists in Medicine
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Variation of small field dosimetry of Novalis Tx beam data: multi-institutional study2018

    • Author(s)
      Yuichi Akino, Hirokazu Mizuno, Yoshihiro Tanaka, Masaru Isono, Norihisa Masai, Toshijiro Yamamoto
    • Organizer
      World Congress on Medical Physics & Biomedical Engineering
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] サイバーナイフ動体追尾照射精度における呼吸位相シフトの影響2018

    • Author(s)
      秋野祐一, 塩見浩也, 鈴木修, 隅田伊織, 東中直一, 林田海織, 馬淵 順久, 小川和彦
    • Organizer
      第116回日本医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Novalis Txの小照射野X線ビームデータ多施設解析2018

    • Author(s)
      秋野祐一, 水野裕一, 田中義浩, 五十野優, 正井範尚, 山本鋭二郎
    • Organizer
      日本放射線腫瘍学会 第31回学術大会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi