Comparison of characteristics, prognosis, and risk factors in HFpEF between Japan and United States

• Project/Area Number: 17K15821
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tohoku University
• Principal Investigator: Nochioka Kotaro 東北大学, 大学病院, 特任准教授 (20598411)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 左室駆主率が保持された心不全 / 予後因子 / 国際比較 / 左室駆出率が保持された心不全 / 左室リモデリング / 収縮能の保持された心不全 / 国際研究 / 心不全 / 疫学

Outline of Final Research Achievements

Heart failure with preserved ejection fraction is a disorder with poor prognosis. Using the data from CHART-2 Study in Japan and TOPCAT in USA, we compared the baseline characteristics and prognostic factors. We found that HFpEF patients in Japan and USA showed similarity with elder and higher prevalence of women. However, medications were different with higher use of beta blocker and diuretics in the HFpEF patients in USA. We also identified age, albumin, anemia, body mass index, BNP and BUN were associated with poor prognosis in both Japan and USA HFpEF patients.

Academic Significance and Societal Importance of the Research Achievements

いまだ確立されていない左室駆出率が保持された心不全の特徴を国際比較することにより、病気の理解や内服治療の似ている点、異なる点の理解が進んだ。また、年齢や貧血、体格、栄養状態といった心臓外で全身状態を表す指標が予後不良と関連していることが示された。今後は貧血や栄養状態の改善を行うことが、このタイプの心不全に有効か今後検討が必要と思われた。

Research Products

• [Int'l Joint Research] Dr. Mark A. Pfeffer/Brigham and Women's Hospital, Boston, MA/United States of America(米国)
• [Int'l Joint Research] Dr. Carolyn S.P. Lam/National Heart Centre Singapore/Singapore(シンガポール)
• [Journal Article] The 3A3B score: The simple risk score for heart failure with preserved ejection fraction - A report from the CHART-2 Study (2019)
  • Author(s): Kasahara Shintaro、Sakata Yasuhiko、Nochioka Kotaro、Tay Wan Ting、Claggett Brian Lee、Abe Ruri、Oikawa Takuya、Sato Masayuki、Aoyanagi Hajime、Miura Masanobu、Shiroto Takashi、Takahashi Jun、Sugimura Koichiro、Teng Tiew-Hwa Katherine、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 284 Pages: 42-49
  • DOI: 10.1016/j.ijcard.2018.10.076
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Conversion formula from B-type natriuretic peptide to N-terminal proBNP values in patients with cardiovascular diseases. (2019)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Miura M, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Journal Title: International Journal of Cardiology Volume: 280 Pages: 184-189
  • DOI: 10.1016/j.ijcard.2018.12.069
  • Peer Reviewed / Open Access
• [Journal Article] Right Ventricular Function, Right Ventricular-Pulmonary Artery Coupling, and Heart Failure Risk in 4 US Communities: The Atherosclerosis Risk in Communities (ARIC) Study. (2018)
  • Author(s): Nochioka K, Querejeta Roca G, Claggett B, Biering-Sorensen T, Matsushita K, Hung CL, Solomon SD, Kitzman D, Shah AM.
  • Journal Title: JAMA Cardiology Volume: 3 Issue: 10 Pages: 939-948
  • DOI: 10.1001/jamacardio.2018.2454
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparable prognostic impact of BNP levels among HFpEF, Borderline HFpEF and HFrEF: a report from the CHART-2 Study. (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Heart Vessels Volume: － Issue: 9 Pages: 1-11
  • DOI: 10.1007/s00380-018-1150-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combination Therapy of Renin Angiotensin System Inhibitors and β-Blockers in Patients with Heart Failure. (2018)
  • Author(s): Nochioka K, Sakata Y, Shimokawa H.
  • Journal Title: Adv Exp Med Biol. Volume: in press Pages: 17-30
  • DOI: 10.1007/5584_2018_179
  • ISBN: 9783319782799, 9783319782805
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. (2018)
  • Author(s): Oikawa T, Sakata Y, Nochioka K, Miura M, Tsuji K, Onose T, Abe R, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART‐2 invesigators.
  • Journal Title: J Am Heart Assoc. Volume: － Issue: 6 Pages: 1-21
  • DOI: 10.1161/jaha.117.007524
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transition of Left Ventricular Ejection Fraction in Heart Failure. (2018)
  • Author(s): Sakata Y, Tsuji K, Nochioka K, Shimokawa H.
  • Journal Title: Adv Exp Med Biol. Volume: in press Pages: 5-15
  • DOI: 10.1007/5584_2018_178
  • ISBN: 9783319782799, 9783319782805
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Urinary sodium excretion in acute heart failure: Interaction between heart and kidney. (2018)
  • Author(s): Nochioka K
  • Journal Title: Int J Cardiol. Volume: 254 Pages: 244-245
  • DOI: 10.1016/j.ijcard.2017.11.098
  • Peer Reviewed
• [Journal Article] Characterization of heart failure patients with mid-range left ventricular ejection fraction-a report from the CHART-2 Study. (2017)
  • Author(s): Tsuji K, Sakata Y, Nochioka K, Miura M, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Eur J Heart Fail Volume: 19 Issue: 10 Pages: 1258-1269
  • DOI: 10.1002/ejhf.807
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Impact of Atrial Fibrillation and New Risk Score of Its Onset in Patients at High Risk of Heart Failure ― A Report From the CHART-2 Study ― (2017)
  • Author(s): Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators
  • Journal Title: Circulation Journal Volume: 81 Issue: 2 Pages: 185-194
  • DOI: 10.1253/circj.CJ-16-0759
  • NAID: 130005298633
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Real-world Application of Big Data in Cardiovascular Science -Report from the Tohoku University Big Data Medicine Center- (2018)
  • Author(s): Nochioka K, Nakayama M, Sakata Y, Shimokawa H.
  • Organizer: 第83回日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] Prognostic Impact of Impaired Glucose Tolerance in Relation with albuminuria in Patients with Chronic Heart Failure: The SUPPORT Trial Subanalysis (2018)
  • Author(s): Kotaro Nochioka, Yasuhiko Sakata, Takashi Shiroto, Takuya Oikawa, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
  • Organizer: 第21回日本心不全学会学術集会（秋田市）
• [Presentation] Microalbuminuria, Impaired Glucose Tolerance, and Their Prognostic Implications in Patients with Chronic Heart Failure: Insights from the SUPPORT Trial (2017)
  • Author(s): Kotaro Nochioka, Yasuhiko Sakata, Takuya Oikawa, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
  • Organizer: AHA Scientific Session（米国アナハイム）
  • Int'l Joint Research
• [Presentation] Association among Impaired Glucose Tolerance, Microalbuminuria and Prognosis in Patients with Chronic Heart Failure. (2017)
  • Author(s): Kotaro Nochioka, Yasuhiko Sakata, Takuya Oikawa, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
  • Organizer: 第21回日本心不全学会学術集会（大阪市）
• [Book] カレントテラピー (2018)
  • Author(s): 後岡広太郎 坂田泰彦 下川宏明
  • Total Pages: 97
  • Publisher: ライフメディコム
• [Remarks] 東北大学循環器内科ホームページ・研究業績（論文・学会発表）
  • URL: http://www.cardio.med.tohoku.ac.jp/class/achievements/index.html