• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of anti-mitochondrial antibodies on chronic respiratory failure

Research Project

Project/Area Number 17K15824
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionNiigata University

Principal Investigator

OHSHIMA Yasuyoshi  新潟大学, 医歯学系, 助教 (90621657)

Project Period (FY) 2017-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords抗ミトコンドリア抗体 / 炎症性筋疾患 / 非侵襲的陽圧換気 / 高二酸化炭素血症 / 内科 / 医療・福祉 / 臨床 / 予防医学
Outline of Final Research Achievements

Inflammatory myopathies associated with anti-mitochondrial antibodies may avoid or wean off noninvasive positive pressure ventilation. The prevalence of anti-mitochondrial antibodies in patients with respiratory disease is not known, so we conducted a survey. In addition, we examined whether hypercarbonemic patients with respiratory disease have a higher prevalence of anti-mitochondrial antibody positivity. The positive rate of AMA-M2 in patients with respiratory disease was 4.4%. AMA-M2 positivity was as high as 11.1% in patients with hypercarbonemia. Inflammatory myopathies associated with anti-mitochondrial antibodies may be more likely to occur among hypercarbonemia and sleep-related hypoventilation cases. It was suggested that it could contribute to avoidance or withdrawal of noninvasive positive pressure ventilation.

Academic Significance and Societal Importance of the Research Achievements

全国には多くの高二酸化炭素血症,慢性Ⅱ型呼吸不全によりNPPV治療中の症例がいる.2012年に,既知の自己抗体陽性の炎症性筋疾患とは異なる特徴を有する,抗ミトコンドリア抗体関連炎症性筋疾患が初めて報告された.本疾患はNPPVの回避や離脱の可能性があるが,呼吸器疾患症例の中でどの程度存在するのか報告したものはない.今回初めて呼吸器疾患症例におけるAMA-M2陽性率を調査し4.4%であること,さらに,高二酸化炭素血症患者では11.1%と高かった.高二酸化炭素血症や睡眠関連低換気症例のなかに抗ミトコンドリア抗体関連炎症性筋疾患が潜在しやすい可能性が示唆され,その学術的・社会的意義は大きい.

Report

(8 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2023 2022 2021

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Variation of respiratory and pulse events in multiple system atrophy2023

    • Author(s)
      Ohshima Yasuyoshi、Hokari Satoshi、Nagai Asuka、Aoki Nobumasa、Watanabe Satoshi、Koya Toshiyuki、Kanazawa Masato、Nakayama Hideaki、Kikuchi Toshiaki、Shimohata Takayoshi
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 115 Pages: 105817-105817

    • DOI

      10.1016/j.parkreldis.2023.105817

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous positive airway pressure treatment reduces renal tubular damage in patients with obstructive sleep apnea: A retrospective single-center cohort study2023

    • Author(s)
      Moriya Rika、Hokari Satoshi、Ohshima Yasuyoshi、Suzuki Ryoko、Nagai Asuka、Fujito Nobuhiro、Takahashi Atsunori、Aoki Nobumasa、Watanabe Satoshi、Koya Toshiyuki、Nakayama Hideaki、Izumizaki Masahiko、Kikuchi Toshiaki
    • Journal Title

      Sleep Medicine

      Volume: 106 Pages: 106-115

    • DOI

      10.1016/j.sleep.2023.03.028

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The relationship between adherence to continuous positive airway pressure and nasal resistance measured by rhinomanometry in patients with obstructive sleep apnea syndrome2023

    • Author(s)
      Fujito Nobuhiro、Ohshima Yasuyoshi、Hokari Satoshi、Takahashi Atsunori、Nagai Asuka、Suzuki Ryoko、Aoki Nobumasa、Watanabe Satoshi、Koya Toshiyuki、Kikuchi Toshiaki
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 3 Pages: e0283070-e0283070

    • DOI

      10.1371/journal.pone.0283070

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 慢性II型呼吸不全に潜在する抗ミトコンドリア抗体陽性患者に関する検討2022

    • Author(s)
      高橋 敦宣,穂苅諭,永井明日香,鈴木涼子,大嶋康義,青木信将,島賢治郎,渡部聡,小屋俊之,菊地利明
    • Organizer
      第62回日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report 2021 Research-status Report
  • [Presentation] 高橋 敦宣, 穂苅 諭, 永井 明日香, 鈴木 涼子, 大嶋 康義, 島 賢治郎, 青木 信将, 渡部 聡, 小屋 俊之, 菊地 利明2022

    • Author(s)
      高二酸化炭素血症患者に抗ミトコンドリア抗体陽性例が潜在している
    • Organizer
      第32回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 2型呼吸不全と抗ミトコンドリアM2抗体の関係性2021

    • Author(s)
      大嶋康義、倉科健司、穂苅諭、永井明日香、鈴木涼子、 青木信将、林正周、渡部聡、小屋俊之、菊地利明
    • Organizer
      第30回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Ⅱ型呼吸不全と抗ミトコンドリアM2抗体の関係性2021

    • Author(s)
      大嶋康義、倉科健司、穂苅諭、永井明日香、鈴木涼子、 青木信将、林正周、渡部聡、小屋俊之、菊地利明
    • Organizer
      第30回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2020 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi