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Development life course approach to birth cohort study

Research Project

Project/Area Number 17K15835
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionKeio University

Principal Investigator

TAKEUCHI Ayano  慶應義塾大学, 医学部(信濃町), 講師 (80511196)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Discontinued (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords疫学統計 / ライフコース疫学 / 環境疫学 / 疫学統計学 / 出生コホート / 同時モデル / 条件付モデル / 疫学研究 / ライフコースアプローチ
Outline of Final Research Achievements

In this study, I targeted environmental factors or environmental chemicals that had small health effects as a single risk factor but large health effects as a composite effect.Such risk factors often cause health problems when exposed at a specific time window(fetal period, infant period, etc.) in life course of human. This study was conducted for the purpose of organizing a statistical model corresponding to situations in which the exposure status changes over time and applying it to birth cohort data.
In this study, I applied joint model and conditional model to the birth cohort data with about 1700 children (follow growth and development of children from the fetal period). I evaluated influence of environmental factors on the presence or absence of allergic diseases at the age of age adjusted by various confounding factors.

Academic Significance and Societal Importance of the Research Achievements

ある時点でベースライン調査を行い、その後対象者を追跡して疾患発症を捉えていくような、おもに成人の生活習慣に起因する慢性疾患を対象とした従来型の疫学調査研究はこの数十年でコホートや調査体制が確立されてきた。それに対して近年は複合的な、より経時的な、より曝露が影響する時期が限定されているといった繊細なデータ解析を必要とするリスク因子を疫学的に評価することが求められてきている。
本研究では、従来型の疫学調査だけでは評価しきれない、子供の成長発達に影響する経時的に変化する曝露や疾患をとらえるライフコース疫学研究に対する統計解析的方法及びその解析事例を提供した。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Presentation (8 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results) Funded Workshop (1 results)

  • [Presentation] Cohort study and environmental exposure, recent progress in Japan2019

    • Author(s)
      Takeuchi A.
    • Organizer
      3rd International Conference on Econometrics and Statistics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of Start Time of Baby Food on Childhood Allergy with Repeatedly Measured Confounder and Intermediator Using Joint and Marginal Model.(Oral)2018

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y.
    • Organizer
      American Statistical Association Joint Statistical Meetings
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Start Time of Baby Food on Childhood Allergy with Repeatedly Measured Confounder and Intermediator Using Joint and Marginal Model.(e-poster)2018

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y
    • Organizer
      American Statistical Association Joint Statistical Meetings
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of indoor environment on children allergy with repeatedly measured confounder and intermediator using trajectory analysis.2018

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y
    • Organizer
      International Society for Environmental Epidemiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct and Indirect Effect of Environmental Factors on Childhood Allergy with Repeatedly Measured Confounder and Intermediator Using Joint and Marginal Model.2018

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y.
    • Organizer
      29th International Biometric Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Start Time of Baby Food on Childhood Allergy with Repeatedly Measured Confounder and Intermediator Using Joint and Marginal Model.(Poster)2017

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y
    • Organizer
      American Statistical Association Joint Statistical Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Start Time of Baby Food on Childhood Allergy with Repeatedly Measured Confounder and Intermediator Using Joint and Marginal Model.(Oral)2017

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y.
    • Organizer
      American Statistical Association Joint Statistical Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of indoor environment on children allergy with repeatedly measured confounder and intermediator using trajectory analysis.2017

    • Author(s)
      Takeuchi A, Narita M, Yamamoto K, Ohya Y.
    • Organizer
      International Society for Environmental Epidemiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] American Statistical Association Joint Statistical Meeting2017

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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