| Project/Area Number |
17K15837
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
Tamaki Junko
Iki Masayuki
Tachiki Takahiro
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | アグリン分解産物 / サルコペニア / 高齢者 / アグリン / コホート研究 / リハビリテーション / 老化 |
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| Outline of Final Research Achievements |
The study subjects were the participants of the follow-up survey of Japanese Population-based Osteoporosis study and were aged 65 years or older in 2011. C-terminal agrin fragment (CAF) concentration was measured by using frozen serum sample obtained in 2011. In the cross sectional analysis, CAF concentration was associated with sarcopenia even after age-adjustment. The number of events of onset sarcopenia in the follow-up survey in 2015-17 was limited. Therefore, in the longitudinal analysis, CAF concentration was not significantly associated with sarcopenia.
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| Academic Significance and Societal Importance of the Research Achievements |
要介護化や死亡のリスク要因であるサルコペニアについて、その発生前に生じると想定されている神経筋シナプスの形態変化のバイオマーカーである血中CAF値について、地域在住女性を対象とし、横断的な解析のみであるがサルコペニアとの関連を確認した。
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