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Identification of non-invasive novel biomarkers predicting future asthma exacerbations in adults and early-onset wheeze in children

Research Project

Project/Area Number 17K15843
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionHokkaido University

Principal Investigator

Goudarzi Houman  北海道大学, 医学研究院, 助教 (40713607)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsBirth cohort / childhood allergies / Overweight and obesity / Biomarkers / Early life wheeze / Urinary biomarkers / Allergies in children / Adult asthma cohort / Allergic diseases / Inflammatory biomarkers / Urine samples / Obesity / Asthma / birth cohort / adult asthma cohort
Outline of Final Research Achievements

We assessed association of early life allergic diseases with overweight/obesity risk in children at age 7. Also, we assessed the association of 3 urinary biomarkers including 8-hydroxy-2 deoxyguanosine (8-OHdG), hexanoyl-lysin (HEL), and 4-hydroxynonenal (4-HNE) with the risk of allergic diseases at age 7 (n=568) and 10 years (n=428). We found the prevalence of rhinitis (3.3 to 21.2%) and eczema (11.3% to 22.4%) increased from early life to age 10. Prevalence of wheeze peaked at 4 years of age (21.6%) with a decline at age 7 (13.3%) and 10 (9.2%). Among children aged 10, 41.5% had at least of the allergic diseases, 46.0% had FeNO >20 p.p.b, and 38.5% had blood eosinophil number >300/µl. At age 10, 70.5% and 22.3% of children were sensitized to inhaled and food allergens, respectively. Wheeze, but not other allergies, at age 0-2, 4 and 7 years of age was associated with risk of overweight/obesity at age 7. Also, HEL had higher levels among children with wheeze at age 7.

Academic Significance and Societal Importance of the Research Achievements

We found that early-life asthma may increase the risk of overweight/obesity. Thus, the prevention of overweight/obesity could be possible with early detection and treatment of asthma. We identified biomarkers associated with allergies and applicable as predictors of wheeze/asthma among children.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 9 results) Remarks (2 results) Funded Workshop (2 results)

  • [Int'l Joint Research] University of Antwerp/Toxicological Center(ベルギー)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Center of Environmental Medicine/Kaohsiung Medical University, Taiwan/NIEHS(その他の国・地域)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Johns Hopkins University/School of Medicne(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Toxicological Center/University of Antwerp/Belgium(ベルギー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Taiwan/National Health Research Institutes/(NHRI)(その他の国・地域)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children2020

    • Author(s)
      Araki Atsuko、Ait Bamai Yu、Bastiaensen Michiel、Van den Eede Nele、Kawai Toshio、Tsuboi Tazuru、Miyashita Chihiro、Itoh Sachiko、Goudarzi Houman、Konno Satoshi、Covaci Adrian、Kishi Reiko
    • Journal Title

      Environmental Research

      Volume: 183 Pages: 109212-109212

    • DOI

      10.1016/j.envres.2020.109212

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms.2019

    • Author(s)
      Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M
    • Journal Title

      The Journal of Allergy and Clinical Immunology: In Practice.

      Volume: 7 Issue: 4 Pages: 1222-1229

    • DOI

      10.1016/j.jaip.2018.11.014

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study2019

    • Author(s)
      Ait Bamai Yu、Bastiaensen Michiel、Araki Atsuko、Goudarzi Houman、Konno Satoshi、Ito Sachiko、Miyashita Chihiro、Yao Yiming、Covaci Adrian、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 131 Pages: 105003-105003

    • DOI

      10.1016/j.envint.2019.105003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children.2018

    • Author(s)
      Goudarzi H, Konno S, Kimura H, Araki A, Miyashita C, Itoh S, Ait Bamai Y, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M, Kishi R.
    • Journal Title

      Science of the Total Environment

      Volume: 639 Pages: 1601-1609

    • DOI

      10.1016/j.scitotenv.2018.05.152

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Childhood allergies and obesity relationship: Identification of non-invasive biomarkers.2019

    • Author(s)
      1.Houman Goudarzi, Satoshi Konno, Atsuko Araki, Sachiko Ito, Yu Ait Bamai, Chihiro Miyashita, Reiko Kishi.
    • Organizer
      European Respiratory Society International Congress, Madrid, Spain
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mixture Chemical Exposure in Utero and Boys Reproductive Hormone Levels at Birth: the Hokkaido study.2019

    • Author(s)
      2.Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Takahiko Mitsui, Houman Goudarzi, Kazutoshi Cho, Kimihiko Moriya, Tamie Nakajima, Yusuke Iwasaki, Tsuguhide Hori, Junboku Kajiwara, Nobuo Shinohara, Reiko Kishi.
    • Organizer
      Joint Meeting of Asian Chapters of International Society for Environmental Epidemiology and the International Society of Exposure Science (ISEE-ISES AC 2019), Daegu, Korea.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children.2019

    • Author(s)
      4.Goudarzi Houman、荒木敦子、伊藤 佐智子、アイツバマイゆふ、宮下ちひろ、木村孔一、今野 哲、岸 玲子.
    • Organizer
      第1回日本アレルギー学会北海道支部地方会.
    • Related Report
      2019 Annual Research Report
  • [Presentation] 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連 (Associations between urinary phosphorous frame retardant metabolites and urinary inflammation markers among school children).2019

    • Author(s)
      5.アイツバマイ ゆふ、Bastiaensen Michiel、荒木 敦子、Goudarzi Houman 、今野哲、伊藤 佐智子、宮下 ちひろ、Covaci Adrian、岸 玲
    • Organizer
      第89回日本衛生学会学術総会. Nagoya, Japan.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential impact of obesity indices on systemic and sputum inflammatory biomarkers among asthma patients.2019

    • Author(s)
      7.Houman Goudarzi, Satoshi Konno, Hironi Makita, Hirokazu Kimura, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Masaharu Nishimura.
    • Organizer
      The 59th Annual Meeting of the Japanese Respiratory Society, Tokyo, Japan.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential impact of obesity indices on systemic inflammatory biomarkers among asthma patients2019

    • Author(s)
      Houman Goudarzi, Satoshi Konno, Hironi Makita, Hirokazu Kimura, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Masaharu Nishimura
    • Organizer
      The 58th Annual Meeting of the Japanese Respiratory Society, 2019 April 12-14, Tokyo, Japan
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連2019

    • Author(s)
      アイツバマイ ゆふ、Bastiaensen Michiel、荒木 敦子、Goudarzi Houman 、今野哲、伊藤 佐智子、宮下 ちひろ、Covaci Adria、岸 玲.
    • Organizer
      衛生学会学術総会. 2019 February 1-3, Nagoya, Japan.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distinct impact of abdominal visceral adiposity on asthma symptoms.2018

    • Author(s)
      Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Nishimura M.
    • Organizer
      European Respiratory Society International Congress, 2018 September 15-19, Paris, France.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Contrasting associations of maternal smoking and BMI with wheeze and eczema in children.2018

    • Author(s)
      Goudarzi H, Konno S, Kimura H, Araki A, Miyashita C, Itoh S, Ait Bamai Y, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M, Kishi R.
    • Organizer
      Japanese Society of Allergology (JSA) 67th Annual Meeting 2018 June 22-24, Chiba, Japan.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distinct impact of abdominal visceral adiposity on asthma symptoms.2018

    • Author(s)
      Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Nishimura M.
    • Organizer
      The 58th Annual Meeting of the Japanese Respiratory Society, 2018 April 27-29, Osaka, Japan.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] The Best Presentation Award in 2018

    • URL

      http://fdm.med.hokudai.ac.jp/trainee/iryou/special/2017/special04-2.html

    • Related Report
      2018 Research-status Report
  • [Remarks] Outstanding Reviewer Award in 2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] Scientific writing workshop2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] Human biomonitoring of emergent contaminants (workshop)2019

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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