| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Nonalcoholic steatohepatis is a liver manifestation of a metabolic syndrome. Growing evidence suggests that NASH is an independent risk factor for cardiovascular disease mortality and morbidity. However, the association between NASH and cardiovascular diseases remain elusive. We aimed to investigate the association of NASH and cardiovascular disease progression using several mouse models. We found that sinusoidal endothelial dysfunction plays gatekeeper role for NASH progression and is associated with other metabolic disorders including obesity. We also revealed that Kupffer cells lead to sinusoidal endothelial dysfunction and hepatic stellate cell activation, and ultimately leading to cirrhosis. These data provide new insights into mechanisms for obesity-related metabolic syndrome.
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