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Investigation of the sympathetic nervous activity as a biomarker for frailty in older adults

Research Project

Project/Area Number 17K15889
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionThe University of Tokyo

Principal Investigator

Shibasaki Koji  東京大学, 医学部附属病院, 登録診療員 (20625735)

Research Collaborator AKISHITA masahiro  
OGAWA sumito  
ASAHI toshiomi  
YAMADA shizuru  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords交感神経 / 自律神経 / フレイル / サルコペニア / 要介護高齢者 / バイオマーカー / 老化
Outline of Final Research Achievements

We showed that older people with frailty, requiring care and dependent activities of daily living (walking, toileting and grooming) were decreased their sympathetic nervous activity compared with older people without frailty. We also found that low sympathetic nervous activity led low blood pressure, disturbance of blood pressure maintenance system and high mortality in older people with decreased sympathetic nervous activity.
In addition, plasma leptin concentration which promotes appetite loss was higher in older people with low sympathetic nervous activity. Our data suggested that low sympathetic nervous activity possibly leads appetite loss and malnutrition. Further we showed the association between behavioral and psychological symptoms of dementia and rehabilitation outcome in hip fractured older people. To recover the behavioral and psychological symptoms of dementia indicated high physical functional recovery during rehabilitation.

Academic Significance and Societal Importance of the Research Achievements

高齢者の要介護要因は脳血管障害、認知症、骨折、高齢による衰弱などが挙げられ、身体機能低下や日常生活動作に障害を生じる。私たちの研究において、高齢者が要介護に陥る原因の一つに自律神経のうち、特に交感神経活性の低下が関与していることが明らかとなった。心電図で測定できる交感神経が高齢者のフレイルや要介護の指標となれば、フレイル、要介護になりやすい高齢者を簡単に予測でき、予防的介入を早期より行うことができるようになる。そして、10兆円を超えた介護保険費用削減の一助にもなりうる可能性が示唆された。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (27 results)

All 2019 2018 2017

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (17 results) (of which Int'l Joint Research: 8 results) Book (2 results)

  • [Journal Article] Plasma Leptin Concentration and Sympathetic Nervous Activity in Older Adults With Physical Dysfunction2018

    • Author(s)
      Shibasaki Koji、Yamada Shizuru、Akishita Masahiro、Ogawa Sumito
    • Journal Title

      Journal of the Endocrine Society

      Volume: 2 Issue: 9 Pages: 1040-1049

    • DOI

      10.1210/js.2018-00104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rehabilitation strategy for hip fracture, focused on behavioral psychological symptoms of dementia for older people with cognitive impairment: A nationwide Japan rehabilitation database.2018

    • Author(s)
      Shibasaki K, Asahi T, Mizobuchi K, Akishita M, Ogawa S.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 7 Pages: e0200143-e0200143

    • DOI

      10.1371/journal.pone.0200143

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chapter 1 Definitions and diagnosis of sarcopenia2018

    • Author(s)
      Akishita Masahiro、Kozaki Koichi、Iijima Katsuya、Tanaka Tomoki、Shibasaki Koji、Ogawa Sumito、Arai Hidenori
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Issue: S1 Pages: 7-12

    • DOI

      10.1111/ggi.13311

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of sarcopenia2018

    • Author(s)
      Shimokata H, Shimada H, Satake S, Endo N, Shibasaki K, Ogawa S, Arai H
    • Journal Title

      Geriatr Gerontol Int

      Volume: 18 Suppl 1 Issue: S1 Pages: 13-22

    • DOI

      10.1111/ggi.13320

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of autonomic nervous activity, as measured by heart rate variability, on the effect of mortality in disabled elderly with low blood pressure in long-term care.2018

    • Author(s)
      Koji Shibasaki, Sumito Ogawa, Shizuru Yamada, Yasuyoshi Ouchi,Masahiro Akishita
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 印刷中 Issue: 8 Pages: 1153-1158

    • DOI

      10.1111/ggi.13328

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The development of pneumothorax in an elderly woman during treatment for nontuberculous mycobacterium2018

    • Author(s)
      Ando K, Ishii M, Yonenaga A, Shibasaki K, Yamaguchi Y, Urano T, Ogawa S, Akishita M.
    • Journal Title

      Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

      Volume: 55 Issue: 1 Pages: 136-142

    • DOI

      10.3143/geriatrics.55.136

    • NAID

      130006434113

    • ISSN
      0300-9173
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of a 78-year-old woman with a neuronal intranuclear inclusion disease.2017

    • Author(s)
      Takumida H, Yakabe M, Mori H, Shibasaki K, Umeda-Kameyama Y, Urano T, Mano T, Hayashi A, Ikemura M, Ogawa S, Akishita M.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17 Issue: 12 Pages: 2623-2625

    • DOI

      10.1111/ggi.13174

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【「サルコペニア診療ガイドライン2017」の要点】 サルコペニアの定義・診断2017

    • Author(s)
      柴崎孝二、秋下雅弘
    • Journal Title

      臨床栄養

      Volume: 132 Pages: 22-27

    • Related Report
      2017 Research-status Report
  • [Presentation] Cognitive Function Test Score With Japanese Fall Risk Index Leads To Fall-prone Inpatients.2018

    • Author(s)
      Saori Harada, Koji Shibasaki, Akiko Sampei, Yuya Yoshioka, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Umeda-Kameyama, Tomohiko Urano, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
    • Organizer
      Gerontological society of America 2018 annual scientific meeting, Boston Massachusetts USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The utility of CGA7, the simplified CGA screening tool in acute care settings2018

    • Author(s)
      Aya Komuro, Shinya Ishii, Miya Oura, Daichi Konno, Tatsuya Hosoi, Koji Shibasaki, Mitsutaka Yakabe, Taro Kojima, Masaki Ishii, Yumi Umeda-Kameyama, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
    • Organizer
      American geriatrics society 2018 annual scientific meeting, Orland Florida, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between urinary incontinence and other geriatric syndromes2018

    • Author(s)
      Miya Oura, Aya Komuro, Daichi Konno, Tatsuya Hosoi, Shinya Ishii, Koji Shibasaki, Mitsutaka Yakabe, Taro Kojima, Masaki Ishii, Yumi Umeda-Kameyama, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
    • Organizer
      American geriatrics society 2018 annual scientific meeting, Orland Florida, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サルコペニア・フレイルの診断・評価と今後の展望2018

    • Author(s)
      柴崎孝二
    • Organizer
      第60回日本老年医学会 シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地域在住高齢者における体重減少と手段的日常生活動作及び身体機能の関連2018

    • Author(s)
      星 絵美、柴崎 孝二、金信敬、山田思鶴、小川純人、秋下雅弘
    • Organizer
      第2回日本リハビリテーション医学会 秋季学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 回復期リハビリテーション病棟における骨関節疾患患者に対する言語聴覚士介入の有用性2018

    • Author(s)
      田島由莉子、柴崎孝二、栗林真里、丸林実季、小川純人、旭俊臣
    • Organizer
      第2回日本リハビリテーション医学会 秋季学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 言語聴覚士の骨関節疾患患者への介入と栄養改善効果について2018

    • Author(s)
      栗林真里、柴崎孝二、田島由莉子、丸林実季、小川純人、旭俊臣
    • Organizer
      第8回日本リハビリテーション栄養学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cognitive function during rehabilitation after hip fracture2017

    • Author(s)
      Koji Shibasaki, Sumito Ogawa, Keiko Mizobuchi, Toshiomi Asahi, Masahiro Akishita
    • Organizer
      International Association of Gerontology and Geriatrics World Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dietary Consumption and Self-Reported Health Status in Older Adults. -A Cross-Sectional Study-2017

    • Author(s)
      Shibasaki Koji, Yamada Shizuru, Ogawa Sumito, Masahiro Akishita
    • Organizer
      European Union Geriatric Medicine Society Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sarcopenia and Sarcopenic Obesity in Japanese Geriatric Ward2017

    • Author(s)
      Akiko Sampei, Saori Harada, Koji Shibasaki, Yuya Yoshioka, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Kameyama, Yasuhiro Yamaguchi, Tomohiko Urano, Sumito Ogawa, Masahiro Akishita
    • Organizer
      European Union Geriatric Medicine Society Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of drug adjustment on hospitalized patients and its examination2017

    • Author(s)
      Yuya Yoshioka, Saori Harada, Koji Shibasaki, ,Akiko Sampei, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Kameyama, Yasuhiro Yamaguchi, Tomohiko Urano, Sumito Ogawa, Masahiro Akishita
    • Organizer
      European Union Geriatric Medicine Society Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Combination of Cognitive Function Test Score and Japanese Fall Risk Index Effectively Identifies the Fall-prone Elderly Patients2017

    • Author(s)
      Saori Harada, Koji Shibasaki, Akiko Sampei, Yuya Yoshioka, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Kameyama, Tomohiko Urano, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
    • Organizer
      European Union Geriatric Medicine Society Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢者の身体機能・体組成とレプチンとの関連性2017

    • Author(s)
      柴崎孝二、小川純人、山田思鶴、秋下雅弘
    • Organizer
      第59回日本老年医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 認知機能障害者における血中レプチン濃度と認知機能との関連2017

    • Author(s)
      柴崎 孝二, 小川 純人, 山田 思鶴, 秋下 雅弘
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] アルツハイマー病患者が弱アルカリ性物質の誤飲を伴い喉頭浮腫を来たした一例2017

    • Author(s)
      大浦 美弥, 濱谷 広頌, 矢可部 満隆, 柴崎 孝二, 石井 正紀, 小島 太郎, 亀山 祐美, 山口 泰弘, 小川 純人, 秋下 雅弘
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 基本チェックリスト評価に基づくフレイルと食品摂取頻度との関連性2017

    • Author(s)
      柴崎 孝二, 小川 純人, 山田 思鶴, 秋下 雅弘
    • Organizer
      日本サルコペニア・フレイル学会 第4回学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 性差に着目した食品摂取頻度と自己健康感との関連2017

    • Author(s)
      柴崎孝二、小川純人、山田思鶴、秋下雅弘
    • Organizer
      第17回日本Men’s Health 医学会
    • Related Report
      2017 Research-status Report
  • [Book] サルコペニア診療実践ガイド2019

    • Author(s)
      荒井秀典、秋下雅弘、飯島勝矢、小川純人、木下かほり、葛谷雅文、神崎恒一、佐竹昭介、柴崎孝二、杉本研、田中友規、山田実、吉村芳弘、楽木宏美、若林秀隆
    • Total Pages
      71
    • Publisher
      ライフサイエンス出版
    • Related Report
      2018 Annual Research Report
  • [Book] サルコペニア診療ガイドライン20172017

    • Author(s)
      サルコペニア診療ガイドライン作成委員会
    • Total Pages
      82
    • Publisher
      ライフサイエンス出版
    • ISBN
      9784897753652
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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