Investigation of the sympathetic nervous activity as a biomarker for frailty in older adults
Project/Area Number |
17K15889
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | The University of Tokyo |
Principal Investigator |
Shibasaki Koji 東京大学, 医学部附属病院, 登録診療員 (20625735)
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Research Collaborator |
AKISHITA masahiro
OGAWA sumito
ASAHI toshiomi
YAMADA shizuru
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Project Period (FY) |
2017-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 交感神経 / 自律神経 / フレイル / サルコペニア / 要介護高齢者 / バイオマーカー / 老化 |
Outline of Final Research Achievements |
We showed that older people with frailty, requiring care and dependent activities of daily living (walking, toileting and grooming) were decreased their sympathetic nervous activity compared with older people without frailty. We also found that low sympathetic nervous activity led low blood pressure, disturbance of blood pressure maintenance system and high mortality in older people with decreased sympathetic nervous activity. In addition, plasma leptin concentration which promotes appetite loss was higher in older people with low sympathetic nervous activity. Our data suggested that low sympathetic nervous activity possibly leads appetite loss and malnutrition. Further we showed the association between behavioral and psychological symptoms of dementia and rehabilitation outcome in hip fractured older people. To recover the behavioral and psychological symptoms of dementia indicated high physical functional recovery during rehabilitation.
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Academic Significance and Societal Importance of the Research Achievements |
高齢者の要介護要因は脳血管障害、認知症、骨折、高齢による衰弱などが挙げられ、身体機能低下や日常生活動作に障害を生じる。私たちの研究において、高齢者が要介護に陥る原因の一つに自律神経のうち、特に交感神経活性の低下が関与していることが明らかとなった。心電図で測定できる交感神経が高齢者のフレイルや要介護の指標となれば、フレイル、要介護になりやすい高齢者を簡単に予測でき、予防的介入を早期より行うことができるようになる。そして、10兆円を超えた介護保険費用削減の一助にもなりうる可能性が示唆された。
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Case of a 78-year-old woman with a neuronal intranuclear inclusion disease.2017
Author(s)
Takumida H, Yakabe M, Mori H, Shibasaki K, Umeda-Kameyama Y, Urano T, Mano T, Hayashi A, Ikemura M, Ogawa S, Akishita M.
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Journal Title
Geriatr Gerontol Int
Volume: 17
Issue: 12
Pages: 2623-2625
DOI
Related Report
Peer Reviewed
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[Presentation] Cognitive Function Test Score With Japanese Fall Risk Index Leads To Fall-prone Inpatients.2018
Author(s)
Saori Harada, Koji Shibasaki, Akiko Sampei, Yuya Yoshioka, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Umeda-Kameyama, Tomohiko Urano, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
Organizer
Gerontological society of America 2018 annual scientific meeting, Boston Massachusetts USA
Related Report
Int'l Joint Research
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[Presentation] The utility of CGA7, the simplified CGA screening tool in acute care settings2018
Author(s)
Aya Komuro, Shinya Ishii, Miya Oura, Daichi Konno, Tatsuya Hosoi, Koji Shibasaki, Mitsutaka Yakabe, Taro Kojima, Masaki Ishii, Yumi Umeda-Kameyama, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
Organizer
American geriatrics society 2018 annual scientific meeting, Orland Florida, USA
Related Report
Int'l Joint Research
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[Presentation] Association between urinary incontinence and other geriatric syndromes2018
Author(s)
Miya Oura, Aya Komuro, Daichi Konno, Tatsuya Hosoi, Shinya Ishii, Koji Shibasaki, Mitsutaka Yakabe, Taro Kojima, Masaki Ishii, Yumi Umeda-Kameyama, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
Organizer
American geriatrics society 2018 annual scientific meeting, Orland Florida, USA
Related Report
Int'l Joint Research
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[Presentation] Sarcopenia and Sarcopenic Obesity in Japanese Geriatric Ward2017
Author(s)
Akiko Sampei, Saori Harada, Koji Shibasaki, Yuya Yoshioka, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Kameyama, Yasuhiro Yamaguchi, Tomohiko Urano, Sumito Ogawa, Masahiro Akishita
Organizer
European Union Geriatric Medicine Society Congress
Related Report
Int'l Joint Research
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[Presentation] The effect of drug adjustment on hospitalized patients and its examination2017
Author(s)
Yuya Yoshioka, Saori Harada, Koji Shibasaki, ,Akiko Sampei, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Kameyama, Yasuhiro Yamaguchi, Tomohiko Urano, Sumito Ogawa, Masahiro Akishita
Organizer
European Union Geriatric Medicine Society Congress
Related Report
Int'l Joint Research
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[Presentation] The Combination of Cognitive Function Test Score and Japanese Fall Risk Index Effectively Identifies the Fall-prone Elderly Patients2017
Author(s)
Saori Harada, Koji Shibasaki, Akiko Sampei, Yuya Yoshioka, Mitsutaka Yakabe, Akihiko Yonenaga, Koichi Toyoshima, Taro Kojima, Masaki Ishii, Yumi Kameyama, Tomohiko Urano, Yasuhiro Yamaguchi, Sumito Ogawa, Masahiro Akishita
Organizer
European Union Geriatric Medicine Society Congress
Related Report
Int'l Joint Research
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