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Elucidation of the Mechanism of Attacks in Familial Mediterranean Fever through the accosiation with menstruation

Research Project

Project/Area Number 17K15892
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionShinshu University

Principal Investigator

Kishida Dai  信州大学, 学術研究院医学系(医学部附属病院), 助教 (50467180)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords家族性地中海熱 / 発熱発作 / 月経 / 誘発因子 / コルヒチン / 女性患者 / MEFV遺伝子 / 遺伝型 / 子宮内膜症 / 自己炎症疾患 / ホルモン療法
Outline of Final Research Achievements

The clinical characteristics of the female patients whose attacks were triggered by menstruation (menstrual-related patients) was shown below. The age at onset and the age at diagnosis in these patients was significantly lower than that in non-menstrual-related patients. Moreover, the percentage of patients with peritonitis was significantly higher in menstrual-related patients. The frequency of attacks, the percentage of symptoms other than peritonitis, and the response to colchicine treatment were not significantly different between the two groups. The proportion of patients complicating endometriosis was significantly higher in the menstrual-related group. With regard to the genetic features, the frequency of p.M694I mutation was higher in menstrual-related patients, but this was not statistically significant.

Academic Significance and Societal Importance of the Research Achievements

女性FMF患者において月経は最大の発作誘発因子となることが示された。月経の度に熱が出る患者に遭遇した際、FMFを想起することの重要性が示されたと言える。子宮内膜症の合併率は高く、子宮内膜症そのものも炎症が関与しているとする研究もあり、両者の関連は興味深い。その他の発作誘発因子と異なり、月経は分かっていても回避することが難しいものではあるが、コルヒチン不応例、不耐例に対し、ホルモン療法が代替治療の一つになる可能性が示唆された。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017 Other

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Late-onset familial Mediterranean fever in Japan2019

    • Author(s)
      Kishida Dai、Yazaki Masahide、Nakamura Akinori、Tsuchiya-Suzuki Ayako、Shimojima Yasuhiro、Sekijima Yoshiki
    • Journal Title

      Modern Rheumatology

      Volume: online first Issue: 3 Pages: 1-4

    • DOI

      10.1080/14397595.2019.1621440

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Familial Mediterranean fever type 2 with heterozygous mutations of E148Q and M694I in a Japanese patient with progressive systemic AA amyloidosis.2019

    • Author(s)
      Ito M, Nobata H, Imai H, Yoshino M, Banno S, Ito Y, Ito H, Kishida D.
    • Journal Title

      Mod Rheumatol Case Reports

      Volume: 3-1 Issue: 1 Pages: 79-85

    • DOI

      10.1080/24725625.2018.1527000

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vertebral artery dissection associated with familial Mediterranean fever and Beh?et's disease2019

    • Author(s)
      Ishikawa Hidehiro、Shindo Akihiro、Ii Yuichiro、Sakano Shoko、Asahi Masaru、Matsuura Keita、Kishida Dai、Umino Maki、Maeda Masayuki、Tomimoto Hidekazu
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 6 Issue: 5 Pages: 974-978

    • DOI

      10.1002/acn3.773

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan.2019

    • Author(s)
      Hosoi T, Ishii K, Tozaka N, Kishida D, Sekijima Y, Tamaoka A
    • Journal Title

      Intern Med.

      Volume: 59-1 Pages: 125-128

    • NAID

      130007779220

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic approach for patients with unidentified fever according to the classical criteria of fever of unknown origin in the field of autoimmune disorders.2019

    • Author(s)
      Watanabe R, Sakuraba H, Hiraga H, Kishida D, Ota S, Hasui K, Kikuchi H, Akemoto Y, Tanaka N, Maeda T, Murai Y, Yoshida S, Tatsuta T, Sawaya M, Chinda D, Mikami T, Ishiguro Y, Fukuda S.
    • Journal Title

      Immunol Med.

      Volume: 42-4 Pages: 176-184

    • NAID

      120007181569

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical familial Mediterranean fever developed in a long-term hemodialysis patient.2018

    • Author(s)
      Makino T, Ohara Y, Kobayashi N, Kono Y, Nomizu A, Ichijo M, Mori Y, Matsui N, Kishida D, Toda T.
    • Journal Title

      Hemodial Int.

      Volume: 22 Issue: 2

    • DOI

      10.1111/hdi.12628

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.2018

    • Author(s)
      Sugie M, Ouchi T, Kishida D, Yasaki S.
    • Journal Title

      Neurol Clin Neurosci.

      Volume: 6 Issue: 6 Pages: 191-193

    • DOI

      10.1111/ncn3.12232

    • NAID

      120007181565

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] One novel and two uncommon MEFV mutations in Japanese patients with familial Mediterranean fever: a clinicogenetic study2017

    • Author(s)
      Kishida D、Yazaki M、Nakamura A、Nomura F、Kondo T、他8名
    • Journal Title

      Rheumatol Int

      Volume: 38 Issue: 1 Pages: 105-110

    • DOI

      10.1007/s00296-017-3886-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 月経期の発熱を契機に診断された家族性地中海熱の8例2017

    • Author(s)
      岡 賢二, 樋口 正太郎, 岸田 大, 矢崎 正英, 中村 昭則, 内川 順子, 山田 靖, 小原 久典, 鹿島 大靖, 宮本 強, 塩沢 丹里
    • Journal Title

      日本女性医学学会雑誌

      Volume: 25 Pages: 34-38

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mediterranean fever gene mutations in patients with possible neuro-Sweet disease: a case series2017

    • Author(s)
      Ishikawa H, Shindo A, Ii Y, Niwa A, Matsuura K, Kishida D, Tomimoto H.
    • Journal Title

      J Neurol Neurosurg Psychiatry.

      Volume: - Issue: 10 Pages: 1119-1121

    • DOI

      10.1136/jnnp-2017-316667

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent pleural effusion is an important diagnostic clue to distinguish familial Mediterranean fever from Behcet's disease2017

    • Author(s)
      Yamaguchi F, Tajika M, Inoue D, Shikama Y, Kishida D, Nakamura A.
    • Journal Title

      Clin Exp Rheumatol.

      Volume: 35 Pages: 135-135

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 注意すべき家族性地中海熱の鑑別診断~他疾患の診断に至った症例を通して~2019

    • Author(s)
      岸田大、中村昭則、矢崎正英、鈴木彩子、下島恭弘、関島良樹
    • Organizer
      第2回 日本免疫不全・自己炎症学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 本邦における家族性地中海熱患者の遺伝子変異2018

    • Author(s)
      岸田大、中村昭則、矢崎正英、鈴木彩子、下島恭弘、関島良樹
    • Organizer
      第1回 日本免疫不全・自己炎症学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 家族性地中海熱類似の症状で発症し、後に他疾患の診断に至った 症例の臨床的・遺伝学的検討2018

    • Author(s)
      岸田大、中村昭則、矢崎正英、鈴木彩子、上野賢一、下島恭弘、関島良樹
    • Organizer
      第62回 日本リウマチ学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Clinical and genetic analysis of patients with symptoms mimicking familial Mediterranean fever2018

    • Author(s)
      Dai Kishida, Akinori Nakamura, Masahide Yazaki, Ayako Tsuchiya-Suzuki, Yasuhiro Shimojima, Yoshiki Sekijima
    • Organizer
      ACR/ARHP Annual Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 中年期以降に発症した家族性地中海熱の臨床的特徴2017

    • Author(s)
      岸田大、矢崎正英、中村昭則、鈴木彩子、上野賢一、下島恭弘、池田修一
    • Organizer
      第61回 日本リウマチ学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Clinical characteristics of patients with late-onset familial Mediterranean fever in Japan2017

    • Author(s)
      Dai Kishida, Masahide Yazaki, Akinori Nakamura, Ayako Tsuchiya-Suzuki, Yasuhiro Shimojima, Yoshiki Sekijima
    • Organizer
      ACR/ARHP Annual Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 信州大学第三内科

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-3nai/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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