The involvement of intestinal mucosa-associated microbiome in disease state of irritable bowel syndrome
| Project/Area Number |
17K15895
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kobe University |
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Principal Investigator |
Inoue Jun 神戸大学, 医学部附属病院, 特定助教 (50631561)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 過敏性腸症候群 / 腸内細菌 |
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| Outline of Final Research Achievements |
Irritable bowel syndrome (IBS) has a high prevalence in Japan, but its pathology is unknown. In IBS patients, the composition of intestinal flora in the mucosal layer and its involvement in the pathological condition are not clear.
The purpose of this study is to collect intestinal bacteria on the mucosal surface using a lower gastrointestinal endoscope and analyze their composition and involvement in pathological conditions.
In this study, we established a method for analyzing the bacterial flora of the mucosal surface layer collected by gastrointestinal endoscopy, and obtained basic knowledge about the bacterial flora of the mucosal surface layer in IBS patients. From this study, the microbiota on the surface of the mucous membrane could serve as a biomarker for IBS diagnosis or disease status. The progress toward research on IBS pathology mediated via microbiome is expected which have great social significance.
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| Academic Significance and Societal Importance of the Research Achievements |
過敏性腸症候群（IBS）において、腸管粘膜表層の細菌叢の構成や病態への関与はこれまでほとんど明らかとされていない。本研究では、消化管内視鏡により採取した粘膜表層の細菌叢の解析方法を確立し、IBS患者の腸管粘膜表層の細菌叢の解析を行った。本研究により、粘膜表層の菌叢の違いがIBS診断や病勢のバイオマーカーとなる可能性や、腸内細菌を介したIBS発病メカニズム研究への進展が見込まれ、その社会的意義は大きい。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Proton Pump Inhibitors Increase the Susceptibility of Mice to Oral Infection with Enteropathogenic Bacteria.2018
Author(s)
1Yasutomi E, Hoshi N, Adachi S, Otsuka T, Kong L, Ku Y, Yamairi H, Inoue J, Ishida T, Watanabe D, Ooi M, Yoshida M, Tsukimi T, Fukuda S, Azuma T.
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Journal Title
Dig Dis Sci.
Volume: 63
Issue: 4
Pages: 881-889
DOI
Related Report
Peer Reviewed
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[Journal Article] Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora.2017
Author(s)
2Adachi S, Hoshi N, Inoue J, Yasutomi E, Otsuka T, Dhakhwa R, Wang Z, Koo Y, Takamatsu T, Matsumura Y, Yamairi H, Watanabe D, Ooi M, Tanahashi T, Nishiumi S, Yoshida M, Azuma T.
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Journal Title
Int Arch Allergy Immunol.
Volume: 173
Issue: 1
Pages: 23-33
DOI
Related Report
Peer Reviewed
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