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Usefullness of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo

Research Project

Project/Area Number 17K15918
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionYamagata University

Principal Investigator

Ishizawa Tetsuya  山形大学, 医学部, 医員 (30594296)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords胆管ステント / PMEA / ミニブタ胆管 / 胆管カバードステント / コーティング / 胆泥閉塞 / ミニブタ
Outline of Final Research Achievements

Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, due to sludge occlusion, the unobstructed period is limited. In this study, we aimed to evaluate the biosafety of a novel CSEMS coated with poly(2-methoxyethyl acrylate) (PMEA-CSEMS) for sludge resistance and examined its biosafety in vivo. We endoscopically placed nine normal porcine bile ducts [PMEA-CSEMS (n = 6) or conventional CSEMS (n = 3)]. The follow-up period was divided into 1, 3, and 6 months, and we performed serological examination and undecalcified histological analysis. Within the follow-up period, for both PMEA-CSEMS and conventional CSEMS, we observed no increase in liver enzyme or inflammatory marker levels in the serological investigation and no inflammatory response and mild fibrosis on histopathological analysis. We demonstrated the biosafety of PMEA-CSEMS for sludge resistance in vivo.

Academic Significance and Societal Importance of the Research Achievements

私たちは、胆泥閉塞を軽減するためPMEAをコーティングしたCSEMS(PMEA-CSEMS)を開発した。PMEA-CSEMSは生体内で安全性を実証できた。また、すでにヒト感染胆汁循環実験でその有効性を確認している。このステントを用いれば、緩和治療として胆管ステントを留置された患者が胆泥閉塞による胆管炎で入退院を繰り返すことなく生活できるようになる可能性がある。医療費の削減にもつながる可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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