| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Several epidemiological studies have indicated that individuals with obesity are at increased risk of colorectal cancer (CRC) and adenoma (CRA). The gut microbiota is affected by dietary patterns and obesity. Several studies have shown the mechanisms by which some bacteria might influence CRC development. Furthermore, accumulated DNA damage has been reported in individuals with obesity.
In this study, we demonstrated that several compositional alterations of the gut microbiota in patients with CRC and suggested that decreased E. faecalis is associated with the obesity-related CRC development. In addition, we found that the somatic alteration landscape differs between obese and non-obese in both CRA and CRC. The gut microbiota and these genomic alterations might be the targets to understand the mechanisms of obesity-associated colorectal carcinogenesis, and they might help to provide new preventive and therapeutic strategies.
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