Elucidation of the pathogenic mechanism of intestinal metaplasia and gastric carcinoma

• Project/Area Number: 17K15928
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: Niikura Ryota 東京大学, 医学部附属病院, 助教 (90625609)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: Helicobacter pylori / gastric metaplasia / gastric atrophy / gastric cancer / proton pump inhibitor / 腸上皮化生 / 胃癌

Outline of Final Research Achievements

Our study investigated clinical and pathological findings of eradication in patients with Helicobacter Pylori. We have shown three new findings as follows.
(i) Acid suppression drug was associated with worsen reversibility of atrophy in antrum and corpus. (ii) Acid suppression drug such as proton pump inhibitors was associated with increased risk of gastric cancer in patients with eradication of Helicobacter Pylori. (iii) Distinct chemopreventive effects of aspirin in diffuse and intestinal type of gastric cancer was found.

Academic Significance and Societal Importance of the Research Achievements

本研究により、ヘリコバクターピロリ菌の除菌後に起こる様々な胃粘膜変化について重要な知見を得ることができた。これらの知見は、ヘリコバクターピロリ菌除菌後に起こりうる胃癌の予測や予防に関して、極めて有用である可能性を秘めている。

Research Products

• [Journal Article] Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case?Control Study, Human Cell Cultures, and In Vivo Preclinical Testing (2019)
  • Author(s): Suzuki Nobumi、Niikura Ryota、Ihara Sozaburo、Hikiba Yohko、Kinoshita Hiroto、Higashishima Naoko、Hayakawa Yoku、Yamada Atsuo、Hirata Yoshihiro、Nakata Ryo、Okamoto Makoto、Sano Munetaka、Kushiyama Akifumi、Ichinose Mari、Woods Susan L.、Worthley Daniel、Iwamoto Yasuhiko、Koike Kazuhiko
  • Journal Title: Cancer Prevention Research Volume: 12 Issue: 3 Pages: 185-194
  • DOI: 10.1158/1940-6207.capr-18-0288
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice (2019)
  • Author(s): Hayakawa Yoku、Tsuboi Mayo、Asfaha Samuel、Kinoshita Hiroto、Niikura Ryota、Konishi Mitsuru、Hata Masahiro、Oya Yukiko、,,,Koike Kazuhiko、Wang Timothy C.
  • Journal Title: Gastroenterology Volume: 156 Issue: 4 Pages: 1066-1081.e16
  • DOI: 10.1053/j.gastro.2018.11.024
  • Peer Reviewed
• [Journal Article] Efficacy of Vonoprazan for Gastroesophageal Reflux Symptoms in Patients with Proton Pump Inhibitor-resistant Non-erosive Reflux Disease (2018)
  • Author(s): Niikura Ryota、Yamada Atsuo、Hirata Yoshihiro、Hayakawa Yoku、Takahashi Akihiro、Shinozaki Tomohiro、Takeuchi Yoshinori、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Internal Medicine Volume: 57 Issue: 17 Pages: 2443-2450
  • DOI: 10.2169/internalmedicine.0492-17
  • NAID: 130007480036
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-09-01
  • Peer Reviewed
• [Journal Article] Distinct chemopreventive effects of aspirin in diffuse and intestinal-type gastric cancer. (2018)
  • Author(s): Niikura R, Hayakawa Y, Hirata Y, Konishi M, Suzuki N, Ihara S, Yamada A, Ushiku T, Fujishiro M, Fukayama M, Koike K.
  • Journal Title: Cancer Prev Res (Phila) Volume: - Issue: 5 Pages: 279-286
  • DOI: 10.1158/1940-6207.capr-17-0276
  • Peer Reviewed
• [Journal Article] Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment forHelicobacter pylori: a retrospective cohort analysis (2017)
  • Author(s): Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Yamada Atsuo、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Gut Volume: epub Issue: 10 Pages: 1908-1910
  • DOI: 10.1136/gutjnl-2017-315710
  • Peer Reviewed