| Project/Area Number |
17K15932
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Shinji
TANABE Minoru
ASAHINA Yasuhiro
KAKINUMA Sei
KANEKO Shun
KAMIYA Akihide
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝細胞癌 / 遺伝子変異 / B型肝炎 / C型肝炎 / 肝炎ウイルス / iPS細胞 |
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| Outline of Final Research Achievements |
We investigated cancer-related genes and viral integration using next generation sequencing in HCC tissues.
In HBs antigen positive HCC, HBV suppression by NUCs may reduce TERT promoter mutation, but not HBV integration. In contrast, HCV eradication has a small influence on gene mutational status in HCV-related HCC. About 10% of NBNC HCC with prior HBV infection had HBV integration and these were developed from normal liver at a younger age. These results above are important and contribute to clarify the mechanisms of the genomic features including HBV integration and the underlying pathway responsible for hepatocarcinogenesis among different etiology and status of viral suppression.
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| Academic Significance and Societal Importance of the Research Achievements |
近年課題となっているHCV排除後やHBV制御下において肝癌を発症した症例に関して癌関連遺伝子変異やウイルスDNAのヒトゲノムへの挿入を調べた。病因やウイルス制御状態により発癌過程が異なる可能性を示しその発癌機構の一端を解明したことにより、発癌予測や治療方針など臨床的な知見となり得る。
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