Impact of anti-tumor immune responses to microenvironment in hepatocellular carcinoma
Project/Area Number |
17K15934
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Kanazawa University |
Principal Investigator |
Takeshi Terashima 金沢大学, 先進予防医学研究センター, 特任准教授 (90775305)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 抗腫瘍免疫 / 肝細胞癌 / 腫瘍浸潤リンパ球 / 個別化医療 / 抗腫瘍免疫反応 |
Outline of Final Research Achievements |
The aim of this study was to immunohistochemically evaluate the surface antigen on tumor infiltrating lymphocytes in hepatocellular carcinoma. We clarified some surface antigen expression on tumor infiltrating lymphocytes into the interior of tumor was a predictive marker for anti-tumor effect of treatment and patients’ outcome.
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Academic Significance and Societal Importance of the Research Achievements |
これまで、肝細胞癌に対する治療方針は主に、大きさや転移の有無などの腫瘍の拡がり(病期)や肝臓の予備能力によって決定されてきた。本研究で、切除後の経過が異なることを明らかにしたことにより、今後は、腫瘍に浸潤した免疫担当細胞の数や種類という、患者さんが持っている抗腫瘍免疫の情報も参考に加えることで、それぞれの患者さんに最適な治療(個別化医療)を提供できる可能性があると考えられる。
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Comparative analysis of liver functional reserve during lenvatinib and sorafenib for advanced hepatocellular carcinoma.2020
Author(s)
Terashima T, Yamashita T, Takata N, Toyama T, Shimakami T, Takatori H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
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Journal Title
Hepatology Research
Volume: -
Issue: 7
Pages: 871-884
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] IL-28B variant as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arteiral infusion chemotherapy.2020
Author(s)
Terashima T, Honda M, Toyama T, Shimakami T, Shimizu R, Takatori H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
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Journal Title
Journal of Gastroenterology and Hepatology
Volume: -
Issue: 10
Pages: 1813-1820
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients.2020
Author(s)
T Seike, E Mizukoshi, K Yamada, H Okada, M Kitahara, T Yamashita, K Arai, T Terashima, N Iida, K Fushimi, T Yamashita, Y Sakai, M Honda, K Harada, S Kaneko.
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Journal Title
J Gastroenterol
Volume: -
Issue: 7
Pages: 701-711
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Germline mutations in cancer-predisposition genes in patients with biliary tract cancer.2019
Author(s)
Terashima T, Umemoto K, Takahashi H, Hosoi H, Takai E, Kondo S, Sakamoto Y, Mitsunaga S, Ohno I, Hashimoto Y, Sasaki M, Ikeda M, Shimada K, Kaneko S, Yachida S, Sugano K, Okusaka T, Morizane C.
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Journal Title
Oncotarget
Volume: 10
Issue: 57
Pages: 5949-5957
DOI
Related Report
Peer Reviewed
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[Journal Article] Characteristics of impaired dendritic cell function in patients with hepatitis B virus infection.2019
Author(s)
Yonejima A, Mizukoshi E, Tamai T, Nakagawa H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Okada H, Yamashita T, Sakai Y, Honda M, Kaneko S.
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Journal Title
Hepatology
Volume: 10.1002/hep
Issue: 1
Pages: 30637-30637
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation.2018
Author(s)
Fujinaga H, Sakai Y, Yamashita T, Arai K, Terashima T, Komura T, Seki A, Kawaguchi K, Nasti A, Yoshida K, Wada T, Yamamoto K, Kume K, Hasegawa T, Takata T, Honda M, Kaneko S.
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Journal Title
Int J Radiat Biol
Volume: 17
Issue: 5
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical characteristics of Japanese patients with epithelioid hemangioendothelioma: a multicenter retrospective study.2018
Author(s)
Shiba S, Imaoka H, Shioji K, Suzuki E, Horiguchi S, Terashima T, Kojima Y, Okuno T, Sukawa Y, Tsuji K, Umemoto K, Asagi A, Todaka A, Ueno M, Ikeda M, Morizane C, Furuse J.
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Journal Title
BMC Cancer
Volume: 18
Issue: 1
Pages: 993-993
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment patterns and outcomes of unresectable pancreatic cancer patients in real-life practice: A region-wide analysis.2018
Author(s)
Terashima T, Yamashita T, Sakai A, Ohta H, Hinoue Y, Toya D, Kawai H, Yonejima M, Urabe T, Noda Y, Mizukoshi E, Kaneko S.
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Journal Title
Jpn J Clin Oncol
Volume: 48
Issue: 11
Pages: 966-973
DOI
Related Report
Peer Reviewed
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[Journal Article] Multicenter retrospective analysis of systemic chemotherapy for unresectable combined hepatocellular and cholangiocarcinoma.2018
Author(s)
Kobayashi S, Terashima T, Shiba S, Yoshida Y, Yamada I, Iwadou S, Horiguchi S, Takahashi H, Suzuki E, Moriguchi M, Tsuji K, Otsuka T, Asagi A, Kojima Y, Takada R, Morizane C, Mizuno N, Ikeda M, Ueno M, Furuse J.
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Journal Title
Cancer Sci
Volume: 109
Issue: 8
Pages: 2549-2557
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: Prospects for regorafenib therapy.2018
Author(s)
Terashima T, Yamashita T, Sunagozaka H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
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Journal Title
Hepatol Res
Volume: 48
Issue: 12
Pages: 956-966
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B.2017
Author(s)
Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S
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Journal Title
J Gastroenterol
Volume: ePub ahead
Issue: 6
Pages: 740-751
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Familial pancreatic cancer: Concept, management and issues2017
Author(s)
Matsubayashi Hiroyuki、Takaori Kyoichi、Morizane Chigusa、Maguchi Hiroyuki、Mizuma Masamichi、Takahashi Hideaki、Wada Keita、Hosoi Hiroko、Yachida Shinichi、Suzuki Masami、Usui Risa、Furukawa Toru、Furuse Junji、Sato Takamitsu、Ueno Makoto、Kiyozumi Yoshimi、Hijioka Susumu、Mizuno Nobumasa、Terashima Takeshi、et al.
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Journal Title
World Journal of Gastroenterology
Volume: 23
Issue: 6
Pages: 935-935
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study.2017
Author(s)
Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
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Journal Title
BMC Cancer
Volume: 17
Issue: 1
Pages: 870-870
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Surrogacy of time to progression for overall survival in advanced hepatocellular carcinoma treated with systemic therapy: A systematic review and meta-analysis of randomized controlled trials2018
Author(s)
Takeshi Terashima, Tatsuya Yamashita, Kuniaki Arai, Tadashi Toyama, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
Organizer
2018 Gastrointestinal Cancer Symposium
Related Report
Int'l Joint Research
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[Presentation] Surrogacy of time to progression for overall survival in advanced hepatocellular carcinoma2018
Author(s)
Takeshi Terashima, Tatsuya Yamashita, Kuniaki Arai, Tadashi Toyama, Kazunori Kawaguchi, Kazuya Kitamura,Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
Organizer
Gastrointestinal Cancers Symposium 2018
Related Report
Int'l Joint Research
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