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Artificial intelligence for endocytoscopy provides fully automated diagnosis of histological healing in ulcerative colitis.

Research Project

Project/Area Number 17K15973
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionShowa University

Principal Investigator

Yashuharu Maeda  昭和大学, 医学部, 兼任講師 (30595616)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords潰瘍性大腸炎 / 粘膜治癒 / 組織学治癒 / 人工知能 / 自動診断システム / CAD / 超拡大内視鏡 / エンドサイトスコピー / 内視鏡
Outline of Final Research Achievements

In this study, we constructed and reported an endoscope automatic diagnosis system for evaluation of inflammatory activity of ulcerative colitis using artificial intelligence. As a pilot study, 22 835 ultra-magnified endoscopic images of 187 patients with ulcerative colitis taken from October 2016 to April 2018 were used. Of these, 12,900 in 87 cases were trained in artificial intelligence, and 9,953 to 525 sets of verification sample sets in 100 cases were created. The diagnostic ability of this system for histologic inflammation with a Geboes score of 3.1 or higher is 74% (95% CI: 65-81), 97% (95-99), 91% (88-93). Met. The diagnostic time per sample was about 0.4 seconds. The above results were reported in Gastrointestinal Endoscopy. (Maeda Y, et al. Gastrointest Endosc 2019.) Furthermore, by March 2019, about 45000 images were collected from 395 patients and the system was up-datad.

Academic Significance and Societal Importance of the Research Achievements

潰瘍性大腸炎は現在罹患患者が急増中の疾患であり本邦で22万人を超えている。つまり専門医のみでなく、一般消化器医が診療する疾患となった。潰瘍性大腸炎患者に対しては、炎症の範囲、程度の評価が必要であり、定期的に大腸内視鏡検査がなされる。大腸粘膜の炎症の残存は病状増悪や大腸癌のリスク因子とされている。しかしながら、これまでの内視鏡診断は①微小の炎症残存を拾い上げられない。②検査医によって診断のばらつき、といった課題がある。本システムはこの二つの課題を克服することを目標する。本システムの実用化は、急増する潰瘍性大腸炎患者に対し、施設や医師を選ばず、専門医と同等の内視鏡診断を可能にすることが期待される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis (with video).2019

    • Author(s)
      Maeda Y, Kudo SE, Mori Y, Misawa M, Ogata N, Sasanuma S, Wakamura K, Oda M, Mori K, Ohtsuka K.
    • Journal Title

      Gastrointest Endosc

      Volume: 89 Issue: 2 Pages: 408-415

    • DOI

      10.1016/j.gie.2018.09.024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特集 炎症性腸疾患の粘膜治癒を考える Ⅱ.各論 (1)潰瘍性大腸炎の画像診断modality d.超拡大内視鏡2018

    • Author(s)
      小形 典之 , 工藤 進英, 前田 康晴 , 森 悠一 , 三澤 将史 , 大塚 和朗 , 笹沼 靖子 1
    • Journal Title

      INTESTINE

      Volume: 22 Issue: 4 Pages: 336-341

    • DOI

      10.19020/INT.0000000216

    • ISSN
      1883-2342, 2433-250X
    • Year and Date
      2018-07-20
    • Related Report
      2018 Annual Research Report
  • [Presentation] Narrow-band imaging併用Endocytoscopy観察による潰瘍性大腸炎の重症度評価2018

    • Author(s)
      前田康晴、工藤進英、小形典之.
    • Organizer
      JDDW 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Narrowband imaging併用Endocytoscopy(EC-NBI)の有用性についての検討2018

    • Author(s)
      前田康晴、工藤進英、小形典之.
    • Organizer
      第95回 日本消化器内視鏡学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Narrow-band imaging併用Endocytoscopy観察による潰瘍性大腸炎の臨床的再燃予測2018

    • Author(s)
      前田康晴、工藤進英、小形典之、森悠一、三澤将史.
    • Organizer
      第36回日本大腸検査学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis2018

    • Author(s)
      Maeda Y, Kudo SE, Mori Y, Misawa M, Ogata N,et al.
    • Organizer
      UEGW2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Narrow-band imaging併用Endocytoscopy(EC-NBI)の有用性についての検討2018

    • Author(s)
      前田康晴、工藤進英、小形典之
    • Organizer
      第95回 日本消化器内視鏡学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Narrow-band imaging併用Endocytoscopyを用いた潰瘍性大 腸炎における組織学的活動性評価の検討2018

    • Author(s)
      小川正隆、工藤進英、前田康晴、森悠一、小形典之
    • Organizer
      第106回日本消化器内視鏡学会関東支部例会
    • Related Report
      2017 Research-status Report
  • [Presentation] Artificial Intelligence for Endocytoscopy Provides Fully Automated Diagnosis of Histological Remission in Ulcerative2017

    • Author(s)
      Maeda Yasuharu, Shinei Kudo, Yuichi Mori, Masashi Misawa, Kunihiko Wakamura, Seiko Hayashi, Noriyuki Ogata, Kenichi Takeda, Toyoki Kudo, Takemasa Hayashi, Atsushi Katagiri, Fumio Ishida, Kazuo Ohtsuka, Masahiro Oda, Kensaku Mori
    • Organizer
      Digestive Disease Week (DDW 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Can Artificial intelligence for endocytoscopy provides fully automated diagnosis of histological healing in ulcerative colitis ?2017

    • Author(s)
      Maeda Yasuharu, Kudo Shin-ei, Mori Yuichi, Misawa Masashi, Ogata Noriyuki, Kenichi Takeda, Toyoki Kudo, Takemasa Hayashi, Atsushi Katagiri, Fumio Ishida, Kazuo Ohtsuka, Masahiro Oda, Kensaku Mori
    • Organizer
      United European Gastroenterology Week (UEGW2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 人工知能は潰瘍性大腸炎の組織学的治癒を予測可能か―Endocytoscopy自動診断システム2017

    • Author(s)
      前田康晴、工藤進英、森悠一、三澤将史、小形典之、小川悠史、一政克朗、武田健一、笹沼靖子、工藤豊樹、林武雅、若村邦彦、石田文生、井上晴洋、 大塚和朗
    • Organizer
      第25回 日本消化器関連学会週間
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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