| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We previously identified opioid growth factor receptor like-1 (OGFRL1) as a novel accelerator of fibrotic liver regeneration in mice. In the present study, we have implicated OGFRL1 in regeneration of the injury/fibrotic liver. Among the peripheral blood cells, monocytes were the major source of OGFRL1. Liver tissue contained a small but significant amount of Ogfrl1 mRNA, which was decreased following repeated CCl4 injections. OGFRL1 was transiently detected in the serum as an exosome-included protein and localized in hepatocytes surrounding the necrotic areas after CCl4-induced liver injury/fibrosis. Administration of OGFRL1-expressing cells into mice with liver fibrosis enhances mobilization of hepatic progenitor cells and stimulates proliferation of hepatocytes after partial hepatectomy.
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