Assessment of risk for colorectal neoplasm in first-degree relatives of colorectal cancer patients

• Project/Area Number: 17K15978
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Sekiguchi Masau 国立研究開発法人国立がん研究センター, 中央病院, 医員 (50648342)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 大腸がん検診 / 大腸癌 / 大腸腫瘍 / 家族歴 / 大腸内視鏡 / 大腸Advanced neoplasia / 第一度近親者 / 大腸advanced neoplasia / 大腸癌スクリーニング

Outline of Final Research Achievements

This study clarified the relationship between family history of colorectal cancer (history of colorectal cancer in first-degree relatives) and the prevalence of advanced colorectal neoplasia in a screened population. A positive family history is associated with a higher prevalence of advanced colorectal neoplasia in younger individuals aged <55 years. The impact of a positive family history is weaker in older individuals aged 55 years or older; however, even in older individuals, a family history of two or more affected first-degree relatives is a strong risk factor for advanced colorectal neoplasia.

Academic Significance and Societal Importance of the Research Achievements

本研究から、大腸がん検診受診者における家族歴（第一度近親者における大腸癌歴）の意義が明らかになった。本研究結果より、大腸癌家族歴のある（40歳以上）55歳未満の検診対象者にはより積極的に検診受診勧奨を行う必要があること、55歳以上で濃厚な家族歴（2人以上の第一度近親者に大腸癌歴がある）を有する場合は最初から大腸内視鏡を行うといったインテンシブな検診を考慮する余地があること、といったことが示唆され、本邦の大腸がん検診向上に向けてこれらの点を提唱していきたい。

Research Products

• [Journal Article] Family history of colorectal cancer and prevalence of advanced colorectal neoplasia in asymptomatic screened populations in different age groups (2020)
  • Author(s): Sekiguchi Masau、Kakugawa Yasuo、Nakamura Keiko、Matsumoto Minori、Tomizawa Yutaka、Murakami Yoshitaka、Saito Yutaka、Matsuda Takahisa
  • Journal Title: Gastrointestinal Endoscopy Volume: Epub ahead of print Issue: 6 Pages: 1-10
  • DOI: 10.1016/j.gie.2020.01.033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cost‐effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score (2020)
  • Author(s): Sekiguchi Masau、Igarashi Ataru、Sakamoto Taku、Saito Yutaka、Esaki Minoru、Matsuda Takahisa
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: Epub ahead of print Issue: 9 Pages: 1-7
  • DOI: 10.1111/jgh.15033
  • Peer Reviewed
• [Journal Article] Incidence of Advanced Colorectal Neoplasia in Individuals With Untreated Diminutive Colorectal Adenomas Diagnosed by Magnifying Image-Enhanced Endoscopy (2019)
  • Author(s): Sekiguchi Masau、Otake Yosuke、Kakugawa Yasuo、Matsumoto Minori、Tomizawa Yutaka、Saito Yutaka、Matsuda Takahisa
  • Journal Title: The American Journal of Gastroenterology Volume: 114 Issue: 6 Pages: 964-973
  • DOI: 10.14309/ajg.0000000000000261
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A scoring model for predicting advanced colorectal neoplasia in a screened population of asymptomatic Japanese individuals. (2018)
  • Author(s): Sekiguchi M, Kakugawa Y, Matsumoto M, Matsuda T.
  • Journal Title: Ｊｏｕｒｎａｌ ｏｆ Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ Volume: 53 Issue: 10 Pages: 1109-1119
  • DOI: 10.1007/s00535-018-1433-7
  • Peer Reviewed
• [Presentation] CLINICAL SIGNIFICANCE OF FAMILY HISTORY OF COLORECTAL CANCER IN FIRST-DEGREE RELATIVES AS A RISK FACTOR FOR ADVANCED COLORECTAL NEOPLASIA IN ASYMPTOMATIC SCREENED POPULATIONS AGED 40 TO 54 YEARS AND 55 TO 69 YEARS (2019)
  • Author(s): Sekiguchi Masau
  • Organizer: 第27回欧州消化器病週間, UEGW2019
  • Int'l Joint Research
• [Presentation] Efforts for perfect colonoscopy in Asia (2019)
  • Author(s): Sekiguchi Masau
  • Organizer: IDEN (International Digestive Endoscopy Network) 2019
  • Int'l Joint Research / Invited
• [Presentation] 教育講演 日本における大腸がん検診の現状と課題 (2019)
  • Author(s): 関口 正宇
  • Organizer: 第49回日本消化器がん検診学会 北海道地方会
  • Invited
• [Presentation] ポリープ切除を伴わない大腸内視鏡検診の可能性 (2019)
  • Author(s): 関口 正宇
  • Organizer: JDDW(第27回日本消化器関連学会週間)
• [Presentation] POTENTIAL ACCEPTABILITY OF A WATCH-AND-WAIT APPROACH FOR DIMINUTIVE COLORECTAL ADENOMAS: FIVE-YEAR INCIDENCE OF ADVANCED COLORECTAL NEOPLASIA IN INDIVIDUALS WITH UNTREATED DIMINUTIVE ADENOMAS (2018)
  • Author(s): Ｍａｓａｕ Ｓｅｋｉｇｕｃｈｉ
  • Organizer: UEG Week 2018
  • Int'l Joint Research
• [Presentation] Incidence of advanced neoplasia after untreated diminutive adenomas: potential for "diagnose-and-do-not-resect" (2018)
  • Author(s): Ｍａｓａｕ Ｓｅｋｉｇｕｃｈｉ
  • Organizer: ＡＰＤＷ 2018
  • Int'l Joint Research
• [Presentation] 大腸がん検診における内視鏡の有効活用に向けて～費用対効果と受診者リスク層別化 の観点から (2018)
  • Author(s): 関口 正宇
  • Organizer: 第104回日本消化器病学会総会
• [Presentation] A new scoring model for predicting advanced colorectal neoplasia in asymptomatic screening population and comparison with the modified Asia-Pacific Colorectal Screening Score (2017)
  • Author(s): Masau Sekiguchi
  • Organizer: UEG Week 2017
  • Int'l Joint Research