| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Recently it is shown that some of the pericytes have multipotency. These pericytes may play an important role in tissue remodeling. Then we identified a specific cell surface marker for multipotent pericytes. This marker allows for the isolation of the multipotent pericytes from normal tissues in mice. Moreover, we found the gene associated with differentiation ability in pericytes from microarray gene expression profiling. In the present study, we investigated this factor, focusing on the angiogenic potential of murine pericytes. Decreased this gene expression in pericytes led to enhancement of angiogenic ability. The findings from this study are expected to bring a new perspective to pathological conditions which are closely related to tissue remodeling such as ischemic disease.
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