| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Vascular endothelium produces endothelium-derived relaxing factors (EDRFs) that modulates vascular tone. Among EDRFs, endothelium-derived hyperpolarization factor (EDHF) is mainly responsible for physiological regulation in microvessels. Thus, present study explored the hypothesis that impaired EDHF-mediated relaxation is involved in the pathogenesis of microvascular angina (MVA).
In patients with MVA, endothelium-dependent vasodilatation of fingertip arterioles to bradykinin was almost absent as assesed by peripheral arterial tonometry (Endo-PAT). Mechanistically, among EDRFs, both nitric oxide (NO)-mediated and EDHF-mediated digital vasodilatations were markedly impared in MVA patients. The results of the present study suggest that MVA is a cardiac manifestation of the systemic small artery disease.
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