| Project/Area Number |
17K15985
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nippon Medical School (2018)
Chiba University (2017) |
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Principal Investigator |
Yuki Ryuzaburo 日本医科大学, 大学院医学研究科, 研究生 (20779897)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エピジェネティクス / 炎症 / 老化 / 肥満 / 幹・前駆細胞 / 分化 / 慢性炎症 / 脂肪 / エピゲノム / 炎症老化 / 脂肪組織 |
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| Outline of Final Research Achievements |
During aging, blood inflammatory cytokines are upregulated and basal level of inflammation is enhanced. Since aging-related diseases are overlapped to inflammatory diseases, aging-induced inflammation might be relevant to onset of aging-related diseases. In this study, we focused on the visceral adipose tissue and analyzed characteristic changes during aging. In aged adipose tissue, inflammation is induced and the inflammation-inducing cells, we previously discovered, is accumulated. Based on the single cell RNA-seq, we could find specific surface markers of its cells and candidates of transcription factors responsible for its differentiation. Furthermore, we could identify responsible transcription factors for its differentiation using an ex vivo culture.
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| Academic Significance and Societal Importance of the Research Achievements |
年を取るとともに糖尿病や脳梗塞・心筋梗塞など動脈硬化性疾患などを発症しやすくなる。これらは肥満によっても発症リスクが増大する疾患であり、近年慢性的な炎症状態が病期にかかりやすい一因であることが分かってきた。高齢者では基礎的なレベルでの炎症度合いが高まっているなど、老化と炎症がリンクする「炎症老化」が注目を集めている。私たちはこれまでに、肥満の際に脂肪に炎症のトリガーを引く新たな細胞を見出しました。本研究を通して、老化した脂肪においても炎症惹起細胞が蓄積していることを見出し、老化による脂肪炎症が様々な加齢関連疾患の発症に繋がっている可能性が示唆されました。
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