| Project/Area Number |
17K16007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 動脈硬化 / 不安定プラーク / 虚血性心疾患 / 心臓CT / プラーク / 急性冠症候群 / 心室内腔 / 血管内プラーク |
|---|
| Outline of Final Research Achievements |
We were able to automatically analyze the roughness of plaque surface in the thoracic aorta using cardiac CT, and to quantify the degree of the toughness. When the degree of the roughness of plaque surface was compared between ischemic heart disease and non-ischemic heart disease, the degree was higher in ischemic heart disease. This finding suggests that the roughness of plaque surface assessed by CT is clinically useful for a risk factor of ischemic heart disease.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、プラークの表面凹凸を定量化し、虚血性心疾患との関連性を示すことができ、診療上、虚血性心疾患のリスクを評価するうえで、有用性が高いと考えられる。また、脂質異常症や2型糖尿病など、虚血性心疾患の予防に対する治療を行ううえでも、臨床的意義が高いと考えられる。さらに、胸部大動脈のプラーク評価は、心臓CTだけではなく通常の造影CTでも可能であり、汎用性にも優れていると思われる。
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