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Analysis of coronary blood flow using fluid dynamics and experimental method

Research Project

Project/Area Number 17K16009
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionEhime University

Principal Investigator

Seike Fumiyasu  愛媛大学, 医学部附属病院, 助教 (10771561)

Project Period (FY) 2021-03-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsFFR / 流体力学 / IVUS / OCT / 心筋虚血 / Fractional flow reserve / Intravascular Ultrasound / 光干渉断層法 / Fractional Flow Reserve / 虚血性心疾患 / 冠動脈 / 冠血流予備量比 / 血管内超音波 / ステント / Myocardial Ischemia / 冠動脈血流 / 狭心症 / 数値流体力学
Outline of Research at the Start

虚血性心疾患は本邦において年々増加しており、その主な侵襲的治療としてカテーテルを用いたステント留置術が行われている。ステントを留置した後に、ステントが閉塞し心筋梗塞を起こすことがあり、その原因の大きな要因としてステントの不完全拡張がしられている。体外実験によりステントの不完全拡張の影響を調べる。
また、粥腫破綻は心筋梗塞の主要な要因である。遠赤外線を用いた冠動脈の構造を再構成し、流体解析を行うことにより、粥腫破綻の詳細な原因の検討を行う。

Outline of Final Research Achievements

The usefulness of fractional flow ratio (FFR) in determining treatment strategy for ischemic heart disease has been established. However, there have been few reports, both in Japan and overseas, on the calculation of FFR using anatomical information of coronary arteries obtained by intracoronary imaging devices (intravascular ultrasonography: IVUS and optical coherence tomography: OCT). Therefore, the applicant has already created a new algorithm to estimate FFR based on fluid dynamics theory using anatomical information. In this application, (1) FFR analysis with anatomical information using the algorithm and (2) analysis of blood flow using computational fluid dynamics software were studied.

Academic Significance and Societal Importance of the Research Achievements

本邦では高齢化、食の欧米化により虚血性心疾患の患者は年々増加してきている。流体力学の理論を用いることにより、心筋梗塞の発症予測、また必ずしも必要のない手術を回避することが可能となりうる、本研究が今後本邦及び今後の虚血性心疾患の治療に与える影響は大きいものと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2021 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results) Presentation (7 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results)

  • [Journal Article] Inter-observer differences in interpretation of coronary pressure-wire pullback data by non-expert interventional cardiologists2021

    • Author(s)
      Takayuki Warisawa, James P Howard, Christopher M Cook, Yousif Ahmad, Shunichi Doi, Masafumi Nakayama, Sonoka Goto, Yohei Yakuta, Kenichi Karube, Fumiyasu Seike, et al.
    • Journal Title

      Cardiovascular Intervention Therapy

      Volume: 36 Issue: 3 Pages: 289-297

    • DOI

      10.1007/s12928-020-00673-3

    • NAID

      40022621525

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional assessment of tandem coronary artery stenosis by intracoronary optical coherence tomography-derived virtual fractional flow reserve: a case series2019

    • Author(s)
      Okuya Yoshiyuki、Seike Fumiyasu、Yoneda Kohei、Takahashi Takefumi、Kishi Koichi、Hiasa Yoshikazu
    • Journal Title

      European Heart Journal - Case Reports

      Volume: 3 Issue: 2

    • DOI

      10.1093/ehjcr/ytz087

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intravascular Ultrasound-Derived Virtual Fractional Flow Reserve for the Assessment of Myocardial Ischemia2018

    • Author(s)
      Fumiyasu Seike
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 3 Pages: 815-823

    • DOI

      10.1253/circj.CJ-17-1042

    • NAID

      130006394522

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intracoronary Optical Coherence Tomography-Derived Virtual Fractional Flow Reserve for the Assessment of Coronary Artery Disease.2017

    • Author(s)
      Fumiyasu Seike
    • Journal Title

      The American Journal of Cardiology

      Volume: 120 Issue: 10 Pages: 1772-1779

    • DOI

      10.1016/j.amjcard.2017.07.083

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Unstable Saphenous Vein Graft Atheroma in Patients With Stable Angina Pectoris.2017

    • Author(s)
      Fumiyasu Seike
    • Journal Title

      Circulation Cardiovascular Intervention

      Volume: 10 Issue: 3

    • DOI

      10.1161/circinterventions.116.004692

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Intravascular Ultrasound-Derived Virtual Fractional Flow Reserve to Predict 3-year Outcomes of Untreated Non-culprit Lesions: The PROSPECT study2021

    • Author(s)
      Fumiyasu Seike, Gary S Mintz, Mitsuaki Matsumura, Ziad A. Ali, Mengdan Liu, Ori Ben-Yehuda, Bernard de Bruyne, Patrick W. Serruys, Kazunori Yasuda, Gregg W. Stone, Akiko Maehara
    • Organizer
      The American College of Cardiology’s (ACC) 70th Annual Scientific Session & Expo
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] OCT of optimal ischemia evaluation method for stable coronary artery disease from the viewpoint of cost- effectiveness.2019

    • Author(s)
      Fumiyasu Seike
    • Organizer
      The 29th Japanese Society of Cardiovascular Imaging & Dynamics 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] IV virtual FFR for the assessment of CAD2019

    • Author(s)
      Fumiyasu Seike
    • Organizer
      Korean Cardiovascular Interventional Imaging Forum 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVUS and OCT of optimal ischemia evaluation method for stable coronary artery disease from the viewpoint of cost effectiveness.2019

    • Author(s)
      Fumiyasu Seike
    • Organizer
      The 29th Japanese Society of Cardiovascular Imaging & Dynamics 2019 in Kurume
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] OCT-derived virtual FFR for the assessment of CAD2018

    • Author(s)
      Fumiyasu Seike
    • Organizer
      Korean Cardiovascular Interventional Imaging Forum 2018 in Swon
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] OCT-derived virtual FFR for the assessment of CAD2018

    • Author(s)
      Fumiyasu Seike
    • Organizer
      The 27th Annual Meeting of the Japanese Association of Cardiovascular Intervention and Therapeutics 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intracoronary Optical Coherence Tomography-Derived Virtual Fractional Flow Reserve for the Assessment of Myocardial Ischemia with Computational Fluid Dynamics Simulation2017

    • Author(s)
      Fumiyasu Seike
    • Organizer
      2017年アメリカ心臓病学会議
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2023-01-30  

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