Significance of cell-free DNA in heart failure
Project/Area Number |
17K16018
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
|
Research Institution | Fukushima Medical University |
Principal Investigator |
|
Project Period (FY) |
2017-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 心不全 / エピジェネティクス / メチル化 / セルフリーDNA / メチル化解析 / エピジェネティックス |
Outline of Final Research Achievements |
The pressure-overload heart model by transverse aortic contraction in mice was generated. Analysis was performed by using the hypertrophic hearts at 1 week and failing hearts at 4 week after surgery. After bisulfite-conversion of the DNA was conducted, DNA methylation analysis by real-time PCR by methylation and unmethylated specific primers showed there were no differences between these diseased hearts and normal hearts in CpG island in ATP2A2 and Dux4. Next, cell-free DNA (cfDNA) were isolated from the serum samples of the patients with heart failure. Quantitative analysis of cfDNA by real-time PCR using LINE1 primer, levels of cfDNA were significantly increased in heart failure patients compared to the subject without heart failure. In the methylation analysis of cfDNA, due to the small amount of cfDNA, digital PCR would be needed to conduct further analysis of cfDNA methylation.
|
Academic Significance and Societal Importance of the Research Achievements |
循環血中セルフリーDNAは主に悪性腫瘍において研究が行われているが、心臓、とくに心不全におけるその意義については明確ではない。本研究では、心不全患者では、心不全を有さない対象と比較して、セルフリーDNAの有意な増加を認めた。方法論としてさらなる検討が必要であるが、心不全の病態・重症度に応じた特異的なDNAメチル化を同定しその程度を評価し得れば、メチル化セルフリーDNAが新たなバイオマーカー・予後指標になる可能性があると考えられ、引き続き解析を進める予定である。
|
Report
(3 results)
Research Products
(23 results)
-
[Journal Article] Plasma levels of melatonin in dilated cardiomyopathy2019
Author(s)
Misaka Tomofumi、Yoshihisa Akiomi、Yokokawa Tetsuro、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Sugimoto Koichi、Kunii Hiroyuki、Nakazato Kazuhiko、Takeishi Yasuchika
-
Journal Title
Journal of Pineal Research
Volume: 66
Issue: 4
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
[Journal Article] A Multiple Biomarker Approach in Patients with Cardiac Sarcoidosis2018
Author(s)
Kiko Takatoyo、Yoshihisa Akiomi、Kanno Yuki、Yokokawa Tetsuro、Abe Satoshi、Miyata-Tatsumi Makiko、Misaka Tomofumi、Oikawa Masayoshi、Kobayashi Atsushi、Ishida Takafumi、Takeishi Yasuchika
-
Journal Title
International Heart Journal
Volume: 59
Issue: 5
Pages: 996-1001
DOI
NAID
ISSN
1349-2365, 1349-3299
Year and Date
2018-09-01
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Association of Serum Zinc Level With Prognosis in Patients With Heart Failure2018
Author(s)
Yoshihisa Akiomi、Abe Satoshi、Kiko Takatoyo、Kimishima Yusuke、Sato Yu、Watanabe Shunsuke、Kanno Yuki、Miyata-Tatsumi Makiko、Misaka Tomofumi、Sato Takamasa、Suzuki Satoshi、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
-
Journal Title
Journal of Cardiac Failure
Volume: 24
Issue: 6
Pages: 375-383
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Presentation] Plasma levels of melatonin in dilated and hypertrophic cardiomyopathies2019
Author(s)
Tomofumi Misaka, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yusuke Kimishima, Yu Sato, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
第83回 日本循環器学会学術集会
Related Report
-
[Presentation] Prognostic impact of restless legs syndrome on patients with heart failure2019
Author(s)
三阪智史, 義久精臣, 一條靖洋, 喜古崇豊, 君島勇輔, 佐藤 悠, 菅野優紀, 滝口 舞, 横川哲朗, 阿部諭史, 佐藤崇匡, 及川雅啓, 小林 淳, 八巻尚洋, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
Organizer
第83回 日本循環器学会学術集会
Related Report
-
-
[Presentation] Prognostic impact of restless legs syndrome on hospitalized heart failure patients.2018
Author(s)
Tomofumi Misaka, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yusuke Kimishima, Yu Sato, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Plasma levels of melatonin in dilated and hypertrophic cardiomyopathies2018
Author(s)
Tomofumi Misaka, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yusuke Kimishima, Yu Sato, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Change in left ventricular ejection fraction and its impact on prognosis in heart failure patients with mid-range ejection fraction2018
Author(s)
Yusuke Kimishima, Akiomi Yoshihisa, Yasuhiro Ichijo, Yu Sato, Takatoyo Kiko, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
-
[Presentation] Characteristics and outcomes of recovered left ventricular ejection fraction in heart failure patients with reduced ejection fraction2018
Author(s)
Yusuke Kimishima, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yu Sato, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Characteristics and outcomes of worsening left ventricular ejection fraction in heart failure patients with preserved ejection fraction2018
Author(s)
Masayoshi Oikawa, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yusuke Kimishima, Yu Sato, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Impact of combined post capillary pulmonary hypertension based on upcoming diagnostic criteria on the prognosis of pulmonary hypertension due to left-sided heart disease2018
Author(s)
Koichi Sugimoto, Akiomi Yoshihisa, Tetsuro Yokokawa, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Impact of diabetes mellitus on the prediction for pulmonary hypertension in the patients with chronic respiratory disease2018
Author(s)
Koichi Sugimoto, Akiomi Yoshihisa, Tomoko Takahashi, Tetsuro Yokokawa, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Low T3 syndrome is associated with high mortality and impaired exercise capacity in hospitalized patients with heart failure2018
Author(s)
Yu Sato, Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Yuki Kanno, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
[Presentation] Prognostic impact of periodic leg movements during sleep on patients with heart failure2018
Author(s)
Yuki Kanno, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yusuke Kimishima, Yu Sato, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
-
[Presentation] Soluble neprilysin does not correlate with outcome in hypertrophic cardiomyopathy2018
Author(s)
Tetsuro Yokokawa, Akiomi Yoshihisa, Yasuhiro Ichijo, Takatoyo Kiko, Yusuke Kimishima, Yu Sato, Mai Takiguchi, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Organizer
Scientific Sessions of American Heart Association 2018
Related Report
Int'l Joint Research
-
-