Relationship between inflammatory monocyte and atherosclerosis

• Project/Area Number: 17K16021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Kashiwagi Manabu 和歌山県立医科大学, 医学部, 助教 (70453181)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 単球サブセット / 急性心筋梗塞 / 単球 / サイトカイン / 冠動脈疾患 / 分子心臓学

Outline of Final Research Achievements

Monocytes in human peripheral blood are heterogeneous. Differential expression of CD14 and CD16 enables monocytes to be divided into two subsets: CD14+CD16－ monocytes and CD14+CD16+ monocytes, called as “inflammatory” and “pro-inflammatory”. We proved that increasing of pro-inflammatory monocyte could predict future coronary artery event. In patients with acute myocardial infarction, both inflammatory monocyte and interleukin-34 increased and related with each other. In addition, those increasing were associated with myocardial remodeling and major adverse cardiovascular events.

Academic Significance and Societal Importance of the Research Achievements

ヒト末梢血単球サブセットの評価が、冠動脈疾患患者におけるリスク層別化に寄与することが示唆された。また炎症性単球とインターロイキン34の上昇は急性心筋梗塞後の心筋救済への関与も示唆されるため、さらなる機序検討により心筋壊死後に対する新規治療の礎となると考えられた。

Research Products

• [Journal Article] Interleukin-34 levels are increased in acute myocardial infarction and associated with major adverse cardiovascular events (2021)
  • Author(s): Manabu Kashiwagi
  • Journal Title: Coronary Artery Disease Volume: -
  • Peer Reviewed
• [Journal Article] Combination of Lesion Stenosis and Myocardial Supply Area Assessed by Coronary Computed Tomography Angiography for Prediction of Myocardial Ischemia (2019)
  • Author(s): Manabu Kashiwagi
  • Journal Title: International Heart Journal Volume: 60 Issue: 6 Pages: 1238-1244
  • DOI: 10.1536/ihj.19-141
  • NAID: 130007753839
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-11-30
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant Coronary Artery Stenosis (2019)
  • Author(s): Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant Coronary Artery Stenosis
  • Journal Title: Circulation Journal Volume: 83 Issue: 11 Pages: 2250-2256
  • DOI: 10.1253/circj.CJ-19-0520
  • NAID: 130007733355
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-10-25
  • Peer Reviewed / Open Access
• [Presentation] ヒト末梢血単球サブセットと冠動脈イベントの関連性の検討 (2018)
  • Author(s): 柏木学
  • Organizer: 第66回日本心臓病学会総会