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Relationship between inflammatory monocyte and atherosclerosis

Research Project

Project/Area Number 17K16021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionWakayama Medical University

Principal Investigator

Kashiwagi Manabu  和歌山県立医科大学, 医学部, 助教 (70453181)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords単球サブセット / 急性心筋梗塞 / 単球 / サイトカイン / 冠動脈疾患 / 分子心臓学
Outline of Final Research Achievements

Monocytes in human peripheral blood are heterogeneous. Differential expression of CD14 and CD16 enables monocytes to be divided into two subsets: CD14+CD16- monocytes and CD14+CD16+ monocytes, called as “inflammatory” and “pro-inflammatory”. We proved that increasing of pro-inflammatory monocyte could predict future coronary artery event. In patients with acute myocardial infarction, both inflammatory monocyte and interleukin-34 increased and related with each other. In addition, those increasing were associated with myocardial remodeling and major adverse cardiovascular events.

Academic Significance and Societal Importance of the Research Achievements

ヒト末梢血単球サブセットの評価が、冠動脈疾患患者におけるリスク層別化に寄与することが示唆された。また炎症性単球とインターロイキン34の上昇は急性心筋梗塞後の心筋救済への関与も示唆されるため、さらなる機序検討により心筋壊死後に対する新規治療の礎となると考えられた。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2021 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Interleukin-34 levels are increased in acute myocardial infarction and associated with major adverse cardiovascular events2021

    • Author(s)
      Manabu Kashiwagi
    • Journal Title

      Coronary Artery Disease

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of Lesion Stenosis and Myocardial Supply Area Assessed by Coronary Computed Tomography Angiography for Prediction of Myocardial Ischemia2019

    • Author(s)
      Manabu Kashiwagi
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 6 Pages: 1238-1244

    • DOI

      10.1536/ihj.19-141

    • NAID

      130007753839

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-11-30
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant Coronary Artery Stenosis2019

    • Author(s)
      Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant Coronary Artery Stenosis
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 11 Pages: 2250-2256

    • DOI

      10.1253/circj.CJ-19-0520

    • NAID

      130007733355

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-10-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒト末梢血単球サブセットと冠動脈イベントの関連性の検討2018

    • Author(s)
      柏木学
    • Organizer
      第66回日本心臓病学会総会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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