Relationship between inflammatory monocyte and atherosclerosis
| Project/Area Number |
17K16021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 単球サブセット / 急性心筋梗塞 / 単球 / サイトカイン / 冠動脈疾患 / 分子心臓学 |
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| Outline of Final Research Achievements |
Monocytes in human peripheral blood are heterogeneous. Differential expression of CD14 and CD16 enables monocytes to be divided into two subsets: CD14+CD16－ monocytes and CD14+CD16+ monocytes, called as “inflammatory” and “pro-inflammatory”. We proved that increasing of pro-inflammatory monocyte could predict future coronary artery event. In patients with acute myocardial infarction, both inflammatory monocyte and interleukin-34 increased and related with each other. In addition, those increasing were associated with myocardial remodeling and major adverse cardiovascular events.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒト末梢血単球サブセットの評価が、冠動脈疾患患者におけるリスク層別化に寄与することが示唆された。また炎症性単球とインターロイキン34の上昇は急性心筋梗塞後の心筋救済への関与も示唆されるため、さらなる機序検討により心筋壊死後に対する新規治療の礎となると考えられた。
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Report
(5 results)
Research Products
(4 results)
