Analysis of a role of ADAMTS13 regarding thrombus formation in kidney
Project/Area Number |
17K16073
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
YOSHIDA YOKO 東京大学, 医学部附属病院, 特任研究員 (90649443)
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Project Period (FY) |
2017-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | ADAMTS13 / VWF / 腎炎 / 血小板 / 血栓性微小血管症 |
Outline of Final Research Achievements |
ADAMTS13 is a specific cleaving protease of von Willebrand factor (VWF), which is a blood glycoprotein involved in hemostasis and thrombosis. In this study, we aim to clarify the effect of ADAMTS13 deficiency on kidney failure (with or without thrombotic microangiopathy) and the role of ADAMTS13 expressed in the kidney. Consequently, we revealed that some kind of challenge related to renal damage led to decreased survival and TTP-like symptoms in ADAMTS13 deficient mice. The results of this study may provide insights into the molecular mechanisms of ADAMTS13-mediated antithrombotic effect in the kidney.
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Academic Significance and Societal Importance of the Research Achievements |
ADAMTS13-VWFと腎臓との関係性は未だ不明な点が多く、本研究の成果はADAMTS13を介した腎臓における血栓制御機構に新たな知見をもたらすことが期待される。また近年、先天性の血栓性血小板減少性紫斑病患者への新規治療薬として遺伝子組み換え型ADAMTS13の有効性が期待されているが、本研究の成果は将来的にこのような薬剤の腎臓における治療効果を提示し得る可能性を秘めており、社会的にも重要性が高いと考えられる。
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Profiles of Coagulation and Fibrinolysis Activation-Associated Molecular Markers of Atypical Hemolytic Uremic Syndrome in the Acute Phase2020
Author(s)
Sakurai S, Kato H, Yoshida Y, Sugawara Y, Fujisawa M, Yasumoto A, Matsumoto M, Fujimura Y, Yatomi Y, Nangaku M
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 27
Issue: 4
Pages: 353-362
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2020-04-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical manifestation of patients with atypical hemolytic uremic syndrome with the C3 p.I1157T variation in the Kinki region of Japan.2018
Author(s)
Matsumoto T, Toyoda H, Amano K, Hirayama M, Ishikawa E, Fujimoto M, Ito M, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Kawamura N, Ikejiri M, Kawakami K, Miyata T, Wada H
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Journal Title
Clin Appl Thromb Hemost
Volume: 24
Issue: 8
Pages: 1301-1307
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome2018
Author(s)
Nakamura H, Oku K, Ogata Y, Ohmura K, Yoshida Y, Kitano E, Fujieda Y, Kato M, Bohgaki T, Amengual O, Yasuda S, Fujimura Y, Seya T, Atsumi T
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Journal Title
Thrombosis Research
Volume: 164
Pages: 63-68
DOI
Related Report
Peer Reviewed
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