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Analysis of tumor-associated microRNAs in hyperparathyroidism

Research Project

Project/Area Number 17K16099
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionTokai University

Principal Investigator

KANAI Genta  東海大学, 医学部, 講師 (00535221)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords副甲状腺機能亢進症 / microRNA / 次世代シーケンサー / 慢性腎臓病 / 次世代シーケンサ― / 二次性副甲状腺機能亢進症 / 次世代シーケンシング / カルシウム受容体
Outline of Final Research Achievements

In this study, to identify miRNAs that regulate function through parathyroid receptors, we examined whether miRNAs associated with tumorigenesis and functional regulation could serve as predictors of SHPT progression and markers of treatment resistance.
RNA extracted from the maximal and minimal glands of the parathyroid gland from a patient with secondary hyperparathyroidism was used for comprehensive analysis of miRNAs using NGS RNA sequencing.
In addition to miRNAs with known functions among 20 representative sequences, four new sequences showed significant differences in function. in vitro, these sequences were examined for function against target mRNAs with complementary sequences in the 3'UTR region, and an action associated with p21/27 was observed.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果によって副甲状腺の段階的腫瘍化仮説における遺伝子発現調節機序の一端が解明されることで、難治性の二次性副甲状腺機能亢進症における進展メカニズムを理解する一助となり、患者の生命予後にかかわる慢性腎臓病における骨ミネラル代謝異常の治療戦略における新たな基礎的知見を与えるものであると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 二次性副甲状腺機能亢進症におけるmicroRNA解析2018

    • Author(s)
      金井 厳太
    • Organizer
      日本腎臓学会
    • Related Report
      2018 Research-status Report
  • [Presentation] MicroRNA Analysis in Secondary Hyperparathyroidism2017

    • Author(s)
      Genta Kanai
    • Organizer
      American Society of Nephrology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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