| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, to identify miRNAs that regulate function through parathyroid receptors, we examined whether miRNAs associated with tumorigenesis and functional regulation could serve as predictors of SHPT progression and markers of treatment resistance.
RNA extracted from the maximal and minimal glands of the parathyroid gland from a patient with secondary hyperparathyroidism was used for comprehensive analysis of miRNAs using NGS RNA sequencing.
In addition to miRNAs with known functions among 20 representative sequences, four new sequences showed significant differences in function. in vitro, these sequences were examined for function against target mRNAs with complementary sequences in the 3'UTR region, and an action associated with p21/27 was observed.
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