| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We examined a hypothesis that glomerulosclerosis induced transformation of type 1 collagen fromα1(I)2α2(I) heterotrimer toα1(I)3 homotrimer, but were not able to prove this hypothesis in the analysis using mass spectrometry. However, in the comprehensive analysis of the changes in sclerosed glomeruli, the levels of PHGDH, which is a rate-limiting enzyme in glycine biosynthesis pathway, was significantly increased. This amino acid is a major component of collagen. This result indicated that this pathway plays an important role in the pathogenesis and development of glomerulosclerosis.
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