Elucidation of human brain excitation and inhibition mechanism by stimulus-induced high frequency activity and its application to treatment of epilepsy
Project/Area Number |
17K16120
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Kyoto University |
Principal Investigator |
小林 勝哉 京都大学, 医学研究科, 特定病院助教 (70737121)
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Project Period (FY) |
2017-04-01 – 2019-03-31
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Project Status |
Discontinued (Fiscal Year 2018)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | てんかん / 皮質皮質間誘発電位 / 刺激誘発性高周波活動 / 自発性高周波活動 / ヒト脳興奮抑制メカニズム / 難治性部分てんかん / 単発皮質電気刺激 |
Outline of Annual Research Achievements |
ヒト脳興奮抑制メカニズムの解明とてんかん治療への臨床応用を目指して、研究を推進した。 術前評価のために頭蓋内電極を慢性留置した計3名のてんかん患者において、発作時脳波記録(gold standard)からてんかん焦点を同定し、同定された正常皮質(てんかん非焦点)・てんかん焦点に網羅的に単発電気刺激を行い、多数の電極で誘発電位(CCEP)と刺激誘発性高周波活動を計測した。頭部画像を元に頭蓋内電極を各脳葉に分類し、正常皮質での脳葉ごとの外的刺激に対する反応性を比較・検討した。CCEP、脳機能・解剖画像、脳機能マッピングでの評価結果より正常皮質を機能野と非機能野に分類し、生理的な刺激誘発性高周波活動の機能野・非機能野での差異を局所レベルおよびネットワークの観点からの解明を試みた。 刺激誘発性高周波活動を正常皮質=生理的とてんかん焦点=病的で比較し、限局した部位での比較であるが、正常皮質よりてんかん焦点でより興奮性が高いことを解明した(国内学会発表、国際学術論文へ報告)。刺激誘発性高周波活動のてんかん焦点に関する感度・特異度の規定を試みたが症例数が少なく今後の検討課題と考える。将来的に改めて症例数を増やしての検討を目指したい。網羅的な評価として、てんかん焦点の局在・病理所見との対比から、病変部位および病因別のてんかん焦点の興奮性を解析したが、同様に症例数が少なく、将来の研究ではさらに多数例での検討を目指したい。また自発性高周波活動と刺激誘発性高周波活動の波形や分布の共通性・差異も検討を開始した状況であった。 新たに、これまで不可能であった刺激部位(刺激電極)での刺激誘発性高周波活動の評価も開始していた。
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Report
(2 results)
Research Products
(53 results)
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[Journal Article] Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery.2018
Author(s)
Neshige S, Matsuhashi M, Kobayashi K, Sakurai T, Shimotake A, Hitomi T, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Miyamoto S, Maruyama H, Matsumoto M, Ikeda A.
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Journal Title
Clin Neurophysiol.
Volume: 129
Issue: 9
Pages: 2038-2048
DOI
Related Report
Peer Reviewed
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[Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study.2017
Author(s)
Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
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Journal Title
Sleep
Volume: 40
Issue: 8
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Presentation] Ictal direct current shifts can be intracranially recorded even with time constant 2 seconds2018
Author(s)
Kajikawa S, Kobayashi K, Daifu M, Matsuhashi M, Hitomi T, Yamao Y, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
Organizer
第59回日本神経学会学術大会
Related Report
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[Presentation] Very small dose of perampanel improved refractory cortical myoclonus2018
Author(s)
Oi K, Kobayashi K, Hitomi T, Shimotake A, Neshige S, Fujii D, Matsumoto R, Kasama S, Kanda M, Wada Y, Takahashi R, Ikeda A
Organizer
第59回日本神経学会学術大会
Related Report
Invited
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[Presentation] 2 types of ictal direct current (DC) shifts were endorsed by time constant 2 seconds in epilepsy surgery2018
Author(s)
Kajikawa S, Kobayashi K, Daifu M, Matsuhashi M, Hitomi T, Yamao Y, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
Organizer
The 12th Asian & Oceanian Epilepsy Congress
Related Report
Int'l Joint Research
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[Presentation] Clinico-electrophysiological impacts of small dosage of perampanel on patients with refractory cortical myoclonus: a case series study2018
Author(s)
Neshige S, Oi K, Kobayashi K, Hitomi T, Shimotake A, Fujii D, Matsumoto R, Kasama S, Kanda M, Wada Y, Takahashi R, Ikeda A
Organizer
The 12th Asian & Oceanian Epilepsy Congress
Related Report
Int'l Joint Research
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[Presentation] Double dissociation of the semantic and phonological processing in reading Kanji and Kana words2018
Author(s)
Daifu M, Matsumoto R, Shimotake A, Ota M, Sakamoto M, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Kambon Ralph MA, Ikeda A
Organizer
The 41st Annual Meeting of the Japan Neuroscience Society
Related Report
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[Presentation] Ictal direct current shifts with time constant (TC) 2 seconds and its comparison with TC 10 seconds: invasive EEG data from intractable human epilepsy2018
Author(s)
Kajikawa S, Kobayashi K, Daifu M, Matsuhashi M, Hitomi T, Yamao Y, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
Organizer
The 41st Annual Meeting of the Japan Neuroscience Society
Related Report
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[Presentation] Co-occurrence of slow and high frequency oscillations (HFOs) in invasively recorded, interictal state in epilepsy patients: Is it a 'Red slow'?2017
Author(s)
Daifu M, Inouchi M, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
Organizer
The XXXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex2017
Author(s)
Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A
Organizer
The XXXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Invasive 3D source localization by wide-band electroencephalography findings2017
Author(s)
Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
Organizer
The XXXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Inhibitory effects of electric cortical stimulation on interictal epileptiform discharges in human epileptic focus2017
Author(s)
Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A
Organizer
The XXXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Efficacy of Wide-Band Electrocorticography(ECoG) on Mapping of the Primary Sensori-Motor Area Compared with Electrical Cortical Stimulation (ECS)2017
Author(s)
Neshige S, Matsuhashi M, Sakurai T, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R and Ikeda A
Organizer
The XXXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Proposal of a diagnostic algorithm for autoimmune epilepsy: a preliminary retrospective cohort study2017
Author(s)
Sakamoto M, Matsumoto R, Togawa J, Takeyama H, Hashi Y, Kobayashi K, Shimotake A, Leypoldt F, Wandinger K.P, Kondo T, Takahashi R, Ikeda A
Organizer
The XXXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Effects of natural sleep and general anesthesia with propofol upon interictal high frequency oscillations (HFOs)2017
Author(s)
Inada T, Kobayashi K, Matsumoto R, Nakae T, Shibata S, Yamao Y, Daifu M, Togawa J, Kikuchi T, Matsuhashi M, Yoshida K, Kunieda T, Kobayashi K, Ikeda A, Miyamoto S
Organizer
The 71st American Epilepsy Society Annual meeting
Related Report
Int'l Joint Research
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[Presentation] Electric cortical stimulation inhibits interictal epileptiform discharge and related high frequency activity in human epileptic focus2017
Author(s)
Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N, Ikeda A
Organizer
The 71st American Epilepsy Society Annual meeting
Related Report
Int'l Joint Research
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[Presentation] Spatio-temporal dynamics of interaction between slow and fast waves in humans during sleep2017
Author(s)
Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
Organizer
The 71st American Epilepsy Society Annual meeting
Related Report
Int'l Joint Research
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[Presentation] Functional connectivity from human superior parietal lobule and medial parietal lobe: A cortico-coritcal evoked potential (CCEP) study2017
Author(s)
Togo M, Matsumoto R, Nakae T, Takeyama H, Kobayashi K, Shimotake A, Usami K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
Organizer
Society for Neuroscience 2017
Related Report
Int'l Joint Research
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[Presentation] Sleep exerts a change in network effective connectivity; Causality analysis of human brain network evoked by single-pulse electrical stimulation2017
Author(s)
Usami K, Korzeniewska A, Matsumoto R, Kunieda T, Mikuni N, Kobayashi K, Kikuchi T, Yoshida K, Miyamoto S, Takahashi R, Ikeda A, Nathan E. Crone
Organizer
The 71st American Epilepsy Society Annual meeting
Related Report
Int'l Joint Research
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[Presentation] Functional gradient of the ventral temporal area in reading Kanji and Kana words -A quantitative low-intensity cortical stimulation study2017
Author(s)
Daifu M, Matsumoto R, Shimotake A, Ota M, Sakamoto M, Nakae T, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph M, Ikeda A
Organizer
第40回日本神経科学大会
Related Report
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[Presentation] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment2017
Author(s)
Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A
Organizer
第40回日本神経科学大会
Related Report
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[Presentation] Effect of natural sleep and general anesthesia on interictal high frequency oscillations on the seizure onset zone2017
Author(s)
Inada T, Kobayashi K, Matsumoto R, Nakae T, Shibata S, Yamao Y, Daifu M, Togawa J, Kikuchi T, Matsuhashi M, Yoshida K, Kunieda T, Kobayashi K, Ikeda A, Miyamoto S
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] Proposal of standard recording and analysis intracranial ictal DC shifts and HFOs2017
Author(s)
Nakatani M, Inouchi M, Togawa J, Murai T, Kobayashi K, Hitomi T, Hashimoto S, Inani M, Shiroku H, Kanazawa K, Watanabe Y, Usui N, Inoue Y, Maehara T, Ikeda A
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] Inhibitory effects of electric cortical stimulation on interictal epileptiform discharges in human epileptic focus2017
Author(s)
Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N, Ikeda A
Organizer
第40回日本神経科学学術大会
Related Report
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[Presentation] Scoring System of Combination of Movement-related Cortical Potential and Event-related Synchronization/De-synchronization for Functional Mapping of Primary Motor Areas Concordant with Electrical Cortical Stimulation2017
Author(s)
Neshige S, Matsuhashi M, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R, Ikeda A
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] Effectiveness of perampanel against refractory cortical myoclonus2017
Author(s)
Oi K, Kobayashi K, Hitomi T, Shimotake A, Neshige S, Fujii D, Matsumoto R, Kasama S, Kanda M, Wada Y, Takahashi R, Ikeda A
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] vidence for the engagement of cortico-cortical and cortico-subcortical networks in generation of epileptic spasms: a combined case study using CCEP and EEG-fMRI2017
Author(s)
Inoue T, Kobayashi K, Matsumoto R, Inouchi M, Togo M, Togawa J, Usami K, Shimotake A, Matsuhashi M, Kikuchi T, Yoshida K, Kawawaki H, Kunieda T, Takahashi R, Ikeda A
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] 前知謬(promnesia)を呈したてんかん患者4例の検討2017
Author(s)
梶川駿介, 小林勝哉, 坂本光弘, 宇佐美清英, 笠井祥子, 本多正幸, 下竹昭寛, 人見建文, 松本理器, 池田明夫, 高橋良輔
Organizer
第31回てんかん学会近畿地方会
Related Report
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[Presentation] Source localization of seizure focus by wide-band stereoelectroencephalography2017
Author(s)
Murai T, Matsuhashi M, Hitomi T, Togo M, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] 自己免疫性てんかんの診断アルゴリズムの提唱:網羅的な抗神経抗体測定からの検証2017
Author(s)
坂本光弘, 松本理器, 十川純平, 武山博文, 端祐一郎, 小林勝哉, 下竹昭寛, F. Laypoldt, K.-P. Wandinger, 近藤誉之, 高橋良輔、池田昭夫
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] 難治部分てんかん患者での単発皮質電気刺激の発作誘発率に関する安全性:皮質皮質間誘発電位計測時の検討2017
Author(s)
小林勝哉, 松本理器, 宇佐美清英, 松橋眞生, 下竹昭寛, 中江卓郎, 武山博文, 菊池隆幸, 吉田和道, 國枝武治, 高橋良輔、池田昭夫
Organizer
第47回日本臨床神経生理学会学術大会
Related Report
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[Presentation] 皮質皮質間誘発電位における非典型波形の検討2017
Author(s)
迎伸孝, 松本理器, 小林勝哉, 十河正弥, 松橋眞生, 中江卓郎, 武山博文, 下竹昭寛, 山尾幸広, 菊池隆幸, 吉田和道, 飯原弘二, 髙橋良輔、池田昭夫
Organizer
第47回日本臨床神経生理学会学術大会
Related Report
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