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Fundamental research for novel obesity and NASH treatment through sphingosine 1-phosphate receptor 2

Research Project

Project/Area Number 17K16144
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionKanazawa University

Principal Investigator

Jun-ichi Morishige  金沢大学, 医学系, 助教 (50423405)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsスフィンゴシン1ーリン酸 / 肥満 / 脂肪肝 / スフィンゴシンキナーゼ / 熱産生 / 褐色脂肪組織 / スフィンゴシン1-リン酸 / トリグリセリド / 脂質
Outline of Final Research Achievements

Sphingosine 1-phosphate (S1P) is bioactive lysophospholipid mediator interacting with five receptors. Here, we investigated the roles of S1P receptor 2 (S1P2) in obesity. S1P2-deficient mice (S1P2 KO) fed high-fat diet showed increased epididymal white adipose tissue weight and decreased liver fat. Moreover, acute cold exposure evoked hypothermia in S1P2 KO mice than in WT mice, showing thermogenic activity is decreased in S1P2 KO mice.

Academic Significance and Societal Importance of the Research Achievements

これまでS1Pと肥満およびメタボリックシンドロームについては,脂肪組織や肝臓を標的として脂肪の蓄積や組織の炎症とS1Pとを関連付けした研究が主であった.本研究で得られた研究成果はS1Pがエネルギー消費に直接的,あるいは間接的に関わっていることを示唆しており,この発見はS1P研究に新たな展開をもたらすものである.また,エネルギー消費機構に関与するS1Pシグナル伝達系を標的とした薬物は,新規な肥満症治療薬 (エネルギー消費促進薬) として利用でき,加えて現存の肥満症治療薬 (エネルギー摂取抑制薬) と併用して使用することでより効果の高い肥満治療法の開発にも繋がるものと考える.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Journal Article (1 results) Book (1 results)

  • [Journal Article] A Cleanup Method for Mass Spectrometric Analysis of Sphingosine- and Ceramide-1-Phosphate in Blood and Solid Tissue Using a Phosphate Capture Molecule2017

    • Author(s)
      Morishige Jun-ichi、Yamashita Ryouhei、Tanaka Tamotsu、Satouchi Kiyoshi
    • Journal Title

      Methods in Molecular Biology

      Volume: 1697 Pages: 57-71

    • DOI

      10.1007/7651_2017_6

    • ISBN
      9781493974122, 9781493974139
    • Related Report
      2017 Research-status Report
  • [Book] Sphingosine-1-Phosphate: Methods and Protocols2018

    • Author(s)
      Alice Pebay, Kursad Turksen
    • Total Pages
      182
    • Publisher
      Springer New York
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2020-03-30  

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