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Elucidation of the relationship between polyamine synthesis and fatty acid synthesis in obesity formation and the investigation of drug targets

Research Project

Project/Area Number 17K16156
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionJikei University School of Medicine

Principal Investigator

TAJIMA AYASA  東京慈恵会医科大学, 医学部, 助教 (20780688)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsポリアミン / アンチザイム / ATPクエン酸リアーゼ / 肥満 / 脂質代謝 / 脂肪酸 / 3T3-L1 / 脂質
Outline of Final Research Achievements

ATP citrate lyase (ACLY) is an acetyl-CoA synthase and is involved in fatty acid synthesis. Previous studies have demonstrated that the polyamine regulator antizyme (AZ) binds ACLY to enhance activity and increase acetyl-CoA production. In this study, I investigated the effect of ACLY on the polyamine metabolism system and investigated its interaction with the fatty acid metabolism. It was found that ACLY is not only used in the fatty acid synthesis system, but it is also consumed in the acetylation of polyamine. This suggests that both metabolic systems are closely related.

Academic Significance and Societal Importance of the Research Achievements

日本人の肥満者(BMI≧25)の割合は、男性 30.7%、女性 21.9% (平成30年度国民健康・栄養調査結果)とされ、肥満は糖尿病・高血圧・脂質異常症と同様に、改善を必要とする生活習慣病であり、効果的な抑制策が必要とされている。そのため、肥満メカニズムの解明は重要であり、本研究により明らかとなった新たな機能から、ACLYを分子標的とする脂肪酸合成系とポリアミン代謝系の両方に影響を及ぼす物質の検索をすることで、今後の肥満の予防法・治療法への応用が期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2020 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Investigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-42020

    • Author(s)
      Takahiko J. Fujimi, Yoshihiro Mezaki, Takahiro Masaki, Ayasa Tajima, Mariko Nakamura, Akira Yoshikawa, Noriyuki Murai, Mamoru Aizawa, Soichi Kojima, Yoshihiro Matsumoto, Hideki Aizaki, Tomokazu Matsuura,
    • Journal Title

      Human Cell

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 22018

    • Author(s)
      Murai Noriyuki、Murakami Yasuko、Tajima Ayasa、Matsufuji Senya
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 3005-3005

    • DOI

      10.1038/s41598-018-21189-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Antizyme and ATP citrate lyase suppresses the cell death of ornithine decarboxylase-overproducing cell line2018

    • Author(s)
      Ayasa Tajima
    • Organizer
      5th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between ATP citrate lyase and Polyamine metabolism2017

    • Author(s)
      Ayasa Tajima
    • Organizer
      Gordon Research Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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