Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
ATP citrate lyase (ACLY) is an acetyl-CoA synthase and is involved in fatty acid synthesis. Previous studies have demonstrated that the polyamine regulator antizyme (AZ) binds ACLY to enhance activity and increase acetyl-CoA production. In this study, I investigated the effect of ACLY on the polyamine metabolism system and investigated its interaction with the fatty acid metabolism. It was found that ACLY is not only used in the fatty acid synthesis system, but it is also consumed in the acetylation of polyamine. This suggests that both metabolic systems are closely related.
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