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Elucidation of the function of neuroestrogen on feeding behavior.

Research Project

Project/Area Number 17K16172
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionFujita Health University

Principal Investigator

Hayashi Takanori  藤田医科大学, 医学部, 講師 (40724315)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsエストロゲン / 食欲 / ニューロエストロゲン / アロマターゼ / ニューロステロイド / MC4R / 女性医学 / 摂食
Outline of Final Research Achievements

In the nerve cells of the brain, estrogen is locally and independently produced, and is involved in various physiological functions. The estrogen synthesized in nerve cells is called neuroestrogen. It is distinguished from estrogen supplied from the ovary and other tissues, and is studied independently.
Although the appetite-suppressing effect of estrogen is clear, the relationship between neuroestrogen and appetite is unknown. So, a detailed analysis was performed using the mouse hypothalamic nerve cell line N38. As a result, it was revealed that in the hypothalamus, neuroestrogens independently act on the appetite regulating nerves to suppress appetite.

Academic Significance and Societal Importance of the Research Achievements

本研究により,独自に調節されているニューロエストロゲンが直接視床下部神経で作用していることが明らかになった。今回のようにエストロゲンとニューロエストロゲンを区別して研究して解析することで,ニューロエストロゲンの神経伝達物質様作用を明らかにすることで,これまで治療困難であった過食,拒食,イライラ食いなどの予防・治療開発につなげたいと考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities.2019

    • Author(s)
      Nishio E, Hayashi T, Nakatani M, Aida N, Suda R, Fujii T, Wakatsuki T, Honda S, Harada N, Shimono Y.
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 20 Pages: 100671-100671

    • DOI

      10.1016/j.bbrep.2019.100671

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.2019

    • Author(s)
      Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y.
    • Journal Title

      Cancer Research

      Volume: 79 Issue: 20 Pages: 5151-5158

    • DOI

      10.1158/0008-5472.can-18-3544

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis2018

    • Author(s)
      Masahiro Hikichi, Yuka Kiriyama, Takanori Hayashi, Kaori Ushimado, Naomi Kobayashi, Makoto Urano, Makoto Kuroda, Toshiaki Utsumi
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 2 Pages: 237-241

    • DOI

      10.2169/internalmedicine.9287-17

    • NAID

      130006309182

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells2018

    • Author(s)
      Hayashi Takanori、Hikichi Masahiro、Yukitake Jun、Wakatsuki Toru、Nishio Eiji、Utsumi Toshiaki、Harada Nobuhiro
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 34 Pages: 23451-23461

    • DOI

      10.18632/oncotarget.25217

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estradiol suppresses phosphorylation of ERα serine 167 through upregulation of PP2A in breast cancer cells2017

    • Author(s)
      Hayashi Takanori、Hikichi Masahiro、Yukitake Jun、Harada Nobuhiro、Utsumi Toshiaki
    • Journal Title

      Oncology Letters

      Volume: 14 Pages: 8060-8065

    • DOI

      10.3892/ol.2017.7216

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] ニューロエストロゲンが摂食行動に及ぼす影響2019

    • Author(s)
      林孝典,西尾永司,本田伸一郎,原田信広
    • Organizer
      女性医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ニューロエストロゲンが摂食行動に及ぼす影響とメカニズム2018

    • Author(s)
      林孝典,本田伸一郎,原田信広
    • Organizer
      ステロイドホルモン学会
    • Related Report
      2018 Research-status Report
  • [Presentation] ニューロエストロゲンが食欲に及ぼす影響2018

    • Author(s)
      林孝典,本田伸一郎,原田信広
    • Organizer
      91回 日本生化学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 摂食関連因子にニューロエストロゲンが及ぼす影響2017

    • Author(s)
      林孝典
    • Organizer
      日本生化学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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