Aberrant expression of mRNA regulated by DNA methyltransferases in therapy-related leukemia

• Project/Area Number: 17K16189
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Nagasaki University
• Principal Investigator: ITONAGA Hidehiro 長崎大学, 原爆後障害医療研究所, 客員研究員 (70530442)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
• Keywords: 治療関連白血病 / 急性白血病 / 骨髄異形成症候群 / 急性骨髄性白血病 / 染色体異常 / 遺伝子異常 / 悪性腫瘍 / 放射線治療 / 化学療法 / クローン性造血 / エピゲノム異常 / DNAメチル化 / マイクロRNA / 白血病 / 遺伝子 / 癌 / 内科

Outline of Final Research Achievements

The aim of this study is to reveal the clinical course of chromosomal and genetic abnormalities before the development of therapy-related leukemia, including acute leukemia and myelodysplastic syndrome. We performed the genetic and chromosomal analysis for the samples from cases who received chemotherapy and/or radiation therapy against malignant diseases. The most important result of this study is that myelodysplastic syndromes were clinically diagnosed in 2 to 5 years following the development of genetic and/or chromosomal abnormalities. In contrast, the diagnosis of acute leukemia was confirmed within several weeks after the detection of genetic and chromosomal abnormalities. In conclusion, this study shows the differences of clinical course (from the development of genetic/chromosomal abnormalities to the clinical diagnosis) by the disease type. The findings from this project were published in two medical journal, and further results are being prepared for the publish.

Academic Significance and Societal Importance of the Research Achievements

本研究成果の学術的意義は、治療関連白血病の発症前の染色体・遺伝子異常の臨床経過と病型（急性白血病と骨髄異形成症候群）の関連性を見出したことである。特に染色体・遺伝子異常の出現が血液検査異常に先行する症例の存在を明らかにしたことは、治療関連白血病の発症機序を解明する上で大きな意義をもつ。本研究の社会的意義として、化学療法や放射線治療を受けた症例において、染色体・遺伝子異常を認めた後に定期的な検査を行って経過を観察する必要性を見出したことである。つまり、本研究の知見は、悪性腫瘍患者における診療の向上に貢献することが期待される。

Research Products

• [Journal Article] Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome (2020)
  • Author(s): Hashimoto M, Itonaga H, Nannya Y, Taniguchi H, Fukuda Y, Furumoto T, Fujioka M, Kasai S, Taguchi M, Taniguchi H, Sato S, Sawayama Y, Atogami S, Iwasaki K, Hata T, Soda H, Moriuchi Y, Nakata K, Ogawa S, Miyazaki Y.
  • Journal Title: Internal Medicine Volume: 59 Issue: 8 Pages: 1081-1086
  • DOI: 10.2169/internalmedicine.3770-19
  • NAID: 130007832473
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-04-15
  • Peer Reviewed / Open Access
• [Journal Article] Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group (2020)
  • Author(s): Kasai Sachie、Itonaga Hidehiro、Niino Daisuke、Miyoshi Hiroaki、Kato Takeharu、Imanishi Daisuke、Fujioka Machiko、Furumoto Takafumi、Sato Shinya、Sawayama Yasushi、Taguchi Jun、Imaizumi Yoshitaka、Hata Tomoko、Yoshida Shinichiro、Moriuchi Yukiyoshi、Ohshima Koichi、Miyazaki Yasushi
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 4 Pages: 524-534
  • DOI: 10.1007/s12185-020-02926-6
  • Peer Reviewed
• [Journal Article] Persistent clonal cytogenetic abnormality with del(20q) from an initial diagnosis of acute promyelocytic leukemia. (2020)
  • Author(s): Fujioka M, Itonaga H, Kato T, Nannya Y, Hashimoto M, Kasai S, Toriyama E, Kamijo R, Taguchi M, Taniguchi H, Sato S, Atogami S, Imaizumi Y, Hata T, Moriuchi Y, Ogawa S, Miyazaki Y.
  • Journal Title: International Journal of Hematology Volume: 111 Issue: 2 Pages: 311-316
  • DOI: 10.1007/s12185-019-02731-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality (2019)
  • Author(s): Toriyama E, Imaizumi Y, Tsuruda K, Itonaga H, Sato S, Ando K, Sawayama Y, Hasegawa H, Hata T, Niino D, Yanagihara K, Miyazaki Y
  • Journal Title: Internal Medicine Volume: 58 Issue: 15 Pages: 2213-2217
  • DOI: 10.2169/internalmedicine.2472-18
  • NAID: 130007686846
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation (2019)
  • Author(s): Itonaga Hidehiro、Ishiyama Ken、Aoki Kazunari、Aoki Jun、Ishikawa Takayuki、Ohashi Kazuteru、Fukuda Takayuki、Ozawa Yukiyasu、Ota Shuichi、Uchida Naoyuki、Eto Tetsuya、Iwato Koji、Ohno Yuju、Takanashi Minoko、Ichinohe Tatsuo、Atsuta Yoshiko、Miyazaki Yasushi
  • Journal Title: Bone Marrow Transplantation Volume: - Issue: 9 Pages: 1471-1481
  • DOI: 10.1038/s41409-019-0469-5
  • NAID: 120006987799
  • Peer Reviewed
• [Journal Article] Increased opportunity for prolonged survival after allogeneic hematopoietic stem cell transplantation in patients aged 60?69?years with myelodysplastic syndrome (2019)
  • Author(s): Itonaga Hidehiro、Ishiyama Ken、Aoki Kazunari、Aoki Jun、Ishikawa Takayuki、Uchida Naoyuki、Ohashi Kazuteru、Ueda Yasunori、Fukuda Takahiro、Sakura Toru、Ohno Yuju、Iwato Koji、Okumura Hirokazu、Kondo Tadakazu、Ichinohe Tatsuo、Takanashi Minoko、Atsuta Yoshiko、Miyazaki Yasushi
  • Journal Title: Annals of Hematology Volume: - Issue: 6 Pages: 1367-1367
  • DOI: 10.1007/s00277-019-03653-7
  • Peer Reviewed
• [Journal Article] Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki (2019)
  • Author(s): Taguchi M, Mishima H, Shiozawa Y, Hayashida C, Kinoshita A, Nannya Y, Makishima H, Horai M, Matsuo M, Sato S, Itonaga H, Kato T, Taniguchi H, Imanishi D, Imaizumi Y, Hata T, Takenaka M, Moriuchi Y, Shiraishi Y, Miyano S, Ogawa S, Yoshiura K-i, Miyazaki Y
  • Journal Title: Haematologica Volume: 105 Issue: 2 Pages: 358-365
  • DOI: 10.3324/haematol.2019.219386
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement (2019)
  • Author(s): Kato Takeharu、Itonaga Hidehiro、Taguchi Jun、Makiyama Junya、Fujioka Machiko、Taguchi Masataka、Horai Makiko、Sawayama Yasushi、Niino Daisuke、Imaizumi Yoshitaka、Hata Tomoko、Yoshida Shinichiro、Sakamoto Kana、Takeuchi Kengo、Ohshima Koichi、Miyazaki Yasushi
  • Journal Title: Leukemia Research Reports Volume: - Pages: 31-33
  • DOI: 10.1016/j.lrr.2019.04.005
  • NAID: 120006987730
  • Peer Reviewed / Open Access
• [Journal Article] Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience (2019)
  • Author(s): Sakamoto Hikaru、Itonaga Hidehiro、Taguchi Jun、Kato Takeharu、Sawayama Yasushi、Hayashi Tomayoshi、Baba Shiro、Moriuchi Masako、Ohshima Koichi、Yoshida Shinichiro、Moriuchi Yukiyoshi、Miyazaki Yasushi
  • Journal Title: Leukemia Research Reports Volume: 11 Pages: 27-30
  • DOI: 10.1016/j.lrr.2019.04.003
  • NAID: 120006987729
  • Peer Reviewed / Open Access
• [Journal Article] Graft-versus-MDS effect after unrelated cord blood transplantation: a retrospective analysis of 752 patients registered at the Japanese Data Center for Hematopoietic Cell Transplantation (2019)
  • Author(s): Ishiyama Ken、Aoki Jun、Itonaga Hidehiro、Uchida Naoyuki、Takahashi Satoshi、Ohno Yuju、Matsuhashi Yoshiko、Sakura Toru、Onizuka Makoto、Miyakoshi Shigesaburo、Takanashi Minoko、Fukuda Takahiro、Atsuta Yoshiko、Nakao Shinji、Miyazaki Yasushi
  • Journal Title: Blood Cancer Journal Volume: 9 Issue: 3 Pages: 31-31
  • DOI: 10.1038/s41408-019-0192-x
  • Peer Reviewed / Open Access
• [Journal Article] Cytomegalovirus reactivation is associated with increased mortality more than 100 days after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma. (2019)
  • Author(s): Sawayama Y, Itonaga H, Fukushima T, Nakano N, Fujiwara H, Utsunomiya A, Fukuda T, Miyamoto T, Eto T, Miyashita K, Nakamae H, Ogata M, Yamanoha A, Miyazaki Y, Kanda J, Atsuta Y, Kato K; ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation.
  • Journal Title: American Journal of Hematology Volume: 94(5) Issue: 5 Pages: 143-146
  • DOI: 10.1002/ajh.25438
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features at transformation in adult T-cell leukemia?lymphoma with smoldering and chronic types (2019)
  • Author(s): Taniguchi Hiroaki、Imaizumi Yoshitaka、Takasaki Yumi、Nakashima Jun、Kato Takeharu、Itonaga Hidehiro、Sato Shinya、Sawayama Yasushi、Ando Koji、Hasegawa Hiroo、Hata Tomoko、Moriuchi Yukiyoshi、Tsukasaki Kunihiro、Miyazaki Yasushi
  • Journal Title: International Journal of Hematology Volume: 109 Issue: 4 Pages: 402-408
  • DOI: 10.1007/s12185-019-02602-4
  • Peer Reviewed
• [Journal Article] Gingival squamous cell carcinoma diagnosed on the occasion of osteonecrosis of the jaw in a patient with chronic GVHD (2019)
  • Author(s): Tsukada S, Itonaga H, Taguchi J, Miyoshi T, Hayashida S, Sato S, Ando K, Sawayama Y, Imaizumi Y, Hata T, Umeda M, Niino D, Miyazaki Y
  • Journal Title: Rinsho Ketsueki Volume: 60 Issue: 1 Pages: 22-27
  • DOI: 10.11406/rinketsu.60.22
  • NAID: 130007590822
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Primary Oral Mucormycosis Due to <i>Rhizopus microsporus</i> after Allogeneic Stem Cell Transplantation (2018)
  • Author(s): Sakamoto Hikaru、Itonaga Hidehiro、Sawayama Yasushi、Taguchi Jun、Saijo Tomomi、Kuwatsuka Sayaka、Hashisako Mikiko、Kinoshita Naoe、Oishi Masao、Doi Hanako、Kosai Kosuke、Nishimoto Katsutaro、Tanaka Katsumi、Yanagihara Katsunori、Mukae Hiroshi、Izumikawa Koichi、Miyazaki Yasushi
  • Journal Title: Internal Medicine Volume: 57 Issue: 17 Pages: 2567-2571
  • DOI: 10.2169/internalmedicine.0474-17
  • NAID: 130007480083
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Complete remission of pure white cell aplasia associated with thymoma after thymectomy and cyclosporine administration (2018)
  • Author(s): Kobayashi Yuji、Ando Koji、Hata Tomoko、Imaizumi Yoshitaka、Nagai Kazuhiro、Kamijyo Rena、Katoh Takeharu、Taguchi Jun、Itonaga Hidehiro、Sato Shinya、Sawayama Yasushi、Miyazaki Yasushi
  • Journal Title: International Journal of Hematology Volume: 109 Issue: 3 Pages: 346-350
  • DOI: 10.1007/s12185-018-02573-y
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for the treatment of BCR-ABL1-negative atypical chronic myeloid leukemia and chronic neutrophil leukemia: A retrospective nationwide study in Japan (2018)
  • Author(s): Itonaga Hidehiro、Ota Shuichi、Ikeda Takashi、Taji Hirohumi、Amano Itsuto、Hasegawa Yuichi、Ichinohe Tatsuo、Fukuda Takahiro、Atsuta Yoshiko、Tanizawa Akihiko、Kondo Takeshi、Miyazaki Yasushi
  • Journal Title: Leukemia Research Volume: 75 Pages: 50-57
  • DOI: 10.1016/j.leukres.2018.11.003
  • NAID: 120006987880
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia (2018)
  • Author(s): Matsuo Hidemasa、Itonaga Hidehiro、et al.
  • Journal Title: Blood Advances Volume: 2 Issue: 21 Pages: 2879-2889
  • DOI: 10.1182/bloodadvances.2018019398
  • NAID: 120006534600
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical factors to predict outcome following mogamulizumab in adult T-cell leukemia-lymphoma (2018)
  • Author(s): Nakashima Jun、Imaizumi Yoshitaka、Taniguchi Hiroaki、Ando Koji、Iwanaga Masako、Itonaga Hidehiro、Sato Shinya、Sawayama Yasuhi、Hata Tomoko、Yoshida Shinichiro、Moriuchi Yukiyoshi、Miyazaki Yasushi
  • Journal Title: International Journal of Hematology Volume: 108 Issue: 5 Pages: 516-523
  • DOI: 10.1007/s12185-018-2509-0
  • Peer Reviewed
• [Journal Article] Durable remission attained with plasmapheresis and intravenous immunoglobulin therapy in a patient with acute exacerbation of GVHD-related myasthenia gravis (2018)
  • Author(s): 中島 潤、宮﨑 泰司、糸永 英弘、藤岡 真知子、千綿 雅彦、澤山 靖、吉村 俊祐、岩永 洋、田口 潤、吉田 真一郎
  • Journal Title: Rinsho Ketsueki Volume: 59 Issue: 5 Pages: 480-484
  • DOI: 10.11406/rinketsu.59.480
  • NAID: 130007384455
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] EPOCH regimen as salvage therapy for adult T-cell leukemia?lymphoma (2018)
  • Author(s): Toriyama Eo、Imaizumi Yoshitaka、Taniguchi Hiroaki、Taguchi Jun、Nakashima Jun、Itonaga Hidehiro、Sato Shinya、Ando Koji、Sawayama Yasushi、Hata Tomoko、Fukushima Takuya、Miyazaki Yasushi
  • Journal Title: International Journal of Hematology Volume: 108 Issue: 2 Pages: 167-175
  • DOI: 10.1007/s12185-018-2455-x
  • Peer Reviewed
• [Journal Article] Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm. (2018)
  • Author(s): Sato S, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Tsushima H, Hata T, Moriuchi Y, Mishima H, Kinoshita A, Yoshiura KI, Miyazaki Y.
  • Journal Title: Int J Hematol. Volume: - Issue: 2 Pages: 213-217
  • DOI: 10.1007/s12185-018-2419-1
  • Peer Reviewed
• [Journal Article] Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia (2018)
  • Author(s): Kamijo Rena、Itonaga Hidehiro、Kihara Rika、Nagata Yasunobu、Hata Tomoko、Asou Norio、Ohtake Shigeki、Shiraishi Yuichi、Chiba Kenichi、Tanaka Hiroko、Miyano Satoru、Ogawa Seishi、Naoe Tomoki、Kiyoi Hitoshi、Miyazaki Yasushi
  • Journal Title: Leukemia Research Volume: 65 Pages: 34-41
  • DOI: 10.1016/j.leukres.2017.12.006
  • NAID: 120006988058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chromosomal analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki. (2018)
  • Author(s): Horai M, Satoh S, Matsuo M, Iwanaga M, Horio K, Jo T, Takasaki Y, Kawaguchi Y, Tsushima H, Yoshida S, Taguchi M, Itonaga H, Sawayama Y, Taguchi J, Imaizumi Y, Hata T, Moriuchi Y, Haase D, Yoshiura KI, Miyazaki Y.
  • Journal Title: Br J Haematol. Volume: 180 Issue: 3 Pages: 381-390
  • DOI: 10.1111/bjh.15050
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan (2018)
  • Author(s): Itonaga Hidehiro、Aoki Kazunari、Aoki Jun、Ishikawa Takayuki、Ishiyama Ken、Uchida Naoyuki、Sakura Toru、Ohashi Kazuteru、Kurokawa Mineo、Ozawa Yukiyasu、Matsuoka Ken-ichi、Nakamura Yukinori、Kimura Fumihiko、Iwato Koji、Nawa Yuichiro、Hirokawa Makoto、Kato Koji、Ichinohe Tatsuo、Atsuta Yoshiko、Miyazaki Yasushi
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 24 Issue: 4 Pages: 840-848
  • DOI: 10.1016/j.bbmt.2017.11.016
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma (2017)
  • Author(s): Kataoka Keisuke、Iwanaga Masako、Yasunaga Jun-ichirou、et al.
  • Journal Title: Blood Volume: 131 Issue: 2 Pages: 215-225
  • DOI: 10.1182/blood-2017-01-761874
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of genetic alterations in stem-cell transplantation for myelodysplasia and secondary acute myeloid leukemia. (2017)
  • Author(s): Yoshizato T, et. al., Sanada M, et. al., Ogawa S.
  • Journal Title: Blood Volume: 129 Issue: 17 Pages: 2347-2358
  • DOI: 10.1182/blood-2016-12-754796
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature (2017)
  • Author(s): Itonaga H, Kato T, Fujioka M, Taguchi M, Taniguchi H, Imaizumi Y, Yoshida S, Miyoshi H, Moriuchi Y, Ohshima K, Miyazaki Y.
  • Journal Title: Internal Medicine Volume: 56 Issue: 14 Pages: 1873-1877
  • DOI: 10.2169/internalmedicine.56.7938
  • NAID: 130005773819
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Presentation] 実臨床における慢性骨髄単球性白血病に対する同種造血幹細胞移植の役割 (2019)
  • Author(s): 藤岡真知子、糸永 英弘 、塚田 幸絵 、坂本 光 、千綿 雅彦、加藤 丈晴 、松尾 真稔、谷口 広明、佐藤 信也、澤山 靖、松尾 江美 、髙﨑 由美 、田口 潤 、今西 大介 、対馬 秀樹、吉田真一郎 、城 達郎 、森内 幸美 、宮﨑 泰司
  • Organizer: 第41回日本造血細胞移植学会総会
• [Presentation] 大量AraCとMTXを含む寛解導入療法で分子遺伝学的寛解を得たドナー細胞由来のMLL-AF4陽性ALL (2018)
  • Author(s): 坂本光、糸永英弘、田口潤、澤山靖、塚田幸絵、北之園英明、田口正剛、佐藤信也、安東恒史、今泉芳孝、波多智子、宮﨑泰司
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] 実臨床におけるCMMLの臨床的特徴と予後について：長崎県下における後方視的解析 (2018)
  • Author(s): Machiko Fujioka, Hidehiro Itonaga, et al.
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 骨病変として再発した2例のTCF3-PBX1陽性成人急性リンパ性白血病 (2018)
  • Author(s): 橋本美紀、糸永英弘、新山侑生、藤岡真知子、坂本光、塚田幸絵、北之園英明、小林裕児、蓬莱真喜子、田口正剛、佐藤信也、安東恒史、澤山靖、今泉芳孝、田口潤、城達郎、波多智子、宮﨑泰司
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 骨髄異形成症候群に対するアザシチジンの実臨床における有用性の検討 (2018)
  • Author(s): 鳥山愛生、波多智子、千綿雅彦、上条玲奈、田口正剛、松尾真稔、小川大輔、松尾江美、堀尾謙介、高崎由美、藤本健志、川口康久、田口潤、城達郎、対馬秀樹、吉田真一郎、森内幸美、糸永英弘、佐藤信也、安東恒史、澤山靖、今泉芳孝、宮﨑泰司
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Interferon-αの併用療法においてDasatinibからNilotinibに変更したT315I変異を伴う慢性骨髄性白血病 (2018)
  • Author(s): 千綿雅彦、糸永英弘、藤岡真知子、中島潤、森沙耶香、佐々木大介、松尾江美、加藤丈晴、吉田真一郎、長谷川寛雄、波多智子、柳原克紀、宮﨑泰司
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] ニロチニブが有効であった維持血液透析施行中の慢性骨髄性白血病 (2018)
  • Author(s): 池内梓、蓬莱真喜子、糸永英弘、塚田幸絵、坂本光、北之園英明、田口正剛、佐藤信也、安東恒史、澤山靖、今泉芳孝、波多智子、森内幸美、宮﨑泰司
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] MLL転座急性骨髄性白血病におけるCCND3遺伝子変異の同定 (2018)
  • Author(s): 松尾英将、吉田健一、福村知隆、塩沢裕介、南谷泰仁、竹田淳恵、上野浩生、柴徳生、大和玄季、半田寛、小野祐一郎、平本展大、石川隆之、臼杵憲祐、石山謙、宮脇修一、糸永英弘ら。
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Allogeneic hematopoietic stem cell transplantation for the treatment of myelodysplastic syndrome in adolescent and young adult patients. (2018)
  • Author(s): Yoshimitsu Shimomura, Masahiko Hara, Takaaki Konuma, Hidehiro Itonaga, et al.
  • Organizer: 60th American Society of Hematology annual meeting
  • Int'l Joint Research
• [Presentation] Genomic analysis of myelodysplastic syndromes among Nagasaki atomic bomb survivors. (2018)
  • Author(s): Masataka Taguchi, Hiroyuki Mishima, usuke Shiozawa, Chisa Hayashida, Akira Kinoshita, Shinya Sato, Makiko Horai, Masatoshi Matsuo, Hidehiro Itonaga, et al.
  • Organizer: 60th American Society of Hematology annual meeting
  • Int'l Joint Research
• [Presentation] Novel and significant impact of germline variants predisposed to pathogenic somatic mutations and loss of heterozygosity (LOH) in myelodysplastic syndromes (MDS) and clonal hematopoiesis of interdeterminate potential (CHIP) (2018)
  • Author(s): Hideki Makishima, Hidehiro Itonaga, et al.
  • Organizer: 60th American Society of Hematology annual meeting
  • Int'l Joint Research
• [Presentation] 大量AraCとMTXを含む寛解後療法で分子遺伝学的寛解を得たドナー細胞由来MLL-AF4陽性ALL (2018)
  • Author(s): 坂本 光、糸永 英弘、田口 潤、澤山 靖、塚田 幸絵、北之園 英明、田口 正剛、佐藤 信也、安東 恒史、今泉 芳孝、波多 智子、宮﨑 泰司
  • Organizer: 第40回日本造血細胞移植学会総会
• [Presentation] Allo-HSCT for patients aged 60 years or older with MDS in Japan. (2017)
  • Author(s): Itonaga H, Ishiyama K, Aoki J, Aoki K, Ishikawa T,
  • Organizer: 14th International Symposium on MDS
  • Int'l Joint Research
• [Presentation] Chromosomal Analysis of Myelodysplastic Syndromes Among Atomic Bomb Survivors in Nagasaki (2017)
  • Author(s): Miyazaki Y, Horai M, Iwanaga M, Sato S, Matsuo M, Horio K, Jo T, Takasaki Y, Kawaguchi Y, Tsushima H, Yoshida S, Taguchi M, Itonaga H, Swayama Y, Taguchi J, Imaizumi Y, Hata T, Moriuchi Y, Haase D, Yoshiura K.
  • Organizer: 59th American Society of Hematology
  • Int'l Joint Research
• [Presentation] Allo-HSCT for chronic neutrophilic leukemia and atypical chronic myeloid leukemia (2017)
  • Author(s): Itonaga H, Miyazaki Y, Imai K, Hasegawa Y, Ikeda T, Taji H, Amano I, Ichinohe T, Fukuda T, Atsuta Y, Tanizawa A, Kondo T.
  • Organizer: 第79回 日本血液学会学術集会
• [Presentation] Successful treatment of azacitidine followed by HSCT for MDS with myelofibrosis (2017)
  • Author(s): Fujioka M, Itonaga H, Tukada S, Sakamoto H, Chiwata M, Toriyama E, Kobayashi Y, Sato S, Sawayama Y, Taguchi J, Imaizumi Y, Hata T, Niino D, Miyazaki Y.
  • Organizer: 第79回 日本血液学会学術集会
• [Presentation] Prognostic value of CMV reactivation on posttransplant outcome among the patients with ATL. (2017)
  • Author(s): Sawayama Y, Itonaga H, Fukushima T, Nakano N, Fujiwara H, Fukuda T, Takatsuka Y, Miyamoto T, Eto T, Nakashima Y, Kanda J, Atsuta Y, Utsunomiya A.
  • Organizer: 第79回 日本血液学会学術集会
• [Presentation] Retrospective analysis of TKI combined chemotherapy for elderly patients with Ph+ALL (2017)
  • Author(s): Sakamoto H, Itonaga H, Fujoka M, Tsukada S, Chiwata M, Toriyama E, Kamijo R, Kitanosono H, Nakashima J, Taguchi M, Kato T, Makiyama J, Sato S, Ando K, Sawayama Y, Imaizumi Y, Yoshida S, Hata T, Moriuchi Y, Miyazaki Y.
  • Organizer: 第79回 日本血液学会学術集会
• [Presentation] U2AF2 mutations in myelodysplastic syndrome. (2017)
  • Author(s): oshizato T, Nannya Y, Atsuta Y, Shiozawa Y, Yoshida K, Onizuka M, Kataoka K, Chiba K, Tanaka H, Shiraishi , Sanada M, Itonaga H, Kanda Y, Miyazaki Y, Miyano S, Makishima H, Ogawa S.
  • Organizer: 第79回 日本血液学会学術集会
• [Book] ヘマトロジー3 －悪性リンパ腫に対する新たな治療展開ー (2020)
  • Author(s): 宮﨑泰司、南谷泰仁、宮﨑泰司、下田和哉、楠本茂、冨田章裕、福原規子、照井康仁、宮脇零士、石前峰斉、江口真理子、糸永英弘、真田昌、近藤英生、木川崇、多賀崇、伊豆津宏二
  • Total Pages: 112
  • Publisher: クリニコ出版
  • ISBN: 9784910396040
• [Book] 血液内科 慢性骨髄単球性白血病の病態と治療 (2019)
  • Author(s): 糸永 英弘
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] 血液内科 第78巻第1号 (2019)
  • Author(s): 糸永英弘、半田寛、田村秀人、三村尚也、今井陽一、菊池次郎、李政樹、伊藤拓水、高松博幸、藤原弘、伊藤薫樹、木崎昌弘、皆方大佑、南陽介、安田貴彦、山岸誠、工藤海、高橋秀一郎、鍵山侑希、竹中克斗、渡邉達郎、山田恭平、西村聡、加留部謙之輔、渡邉純一
  • Total Pages: 152
  • Publisher: 科学評論社
• [Book] 血液内科 第77巻第2号 (2018)
  • Author(s): 糸永英弘、西村純一、安藤潔、小林幸夫、市川幹、熊本忠史、村田誠、近藤健、南陽介、今井陽一、李政樹、石澤賢一、福原規子、川上徹、塚田信弘、塩澤裕介、熊浦三奈、横山明彦、沖田南都子、松岡賢市、矢野尊啓、岡田隆宏、渡邊健、佐川森彦、鈴木憲史
  • Total Pages: 143
  • Publisher: 科学評論社
• [Book] 血液フロンティア 2018年12月号 (2018)
  • Author(s): 糸永英弘、宮﨑泰司、牧島秀樹、臼杵憲祐、石山謙
  • Total Pages: 134
  • Publisher: 医薬ジャーナル社
• [Book] モダンメディア (2018)
  • Author(s): 糸永 英弘、宮﨑 泰司、酒巻 望、岩本 愛吉、三村 智憲。
  • Total Pages: 22
  • Publisher: 栄研化学株式会社
• [Book] 血液内科 (2018)
  • Author(s): 糸永 英弘、波多 智子、材木 義隆、臼杵 憲祐、藤島 直仁、北中 明、古屋 淳史、村主 啓行、川口 辰哉、亀崎 豊実、幣 光太郎、桐戸 敬太、平林 真介、谷口 俊恭、張替 秀郎、牧 宏彰、藤原 亨、中世古 知昭、小沼 貴晶、田矢 祐規、ほか。
  • Total Pages: 150
  • Publisher: 科学評論社