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IFNgamma-mediated regulation of hematopoeitc stem cells in stress hematopoiesis

Research Project

Project/Area Number 17K16190
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKumamoto University

Principal Investigator

Umemoto Terumasa  熊本大学, 国際先端医学研究機構, 特任助教 (50620225)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords造血幹細胞
Outline of Final Research Achievements

So far, it is thought that HSCs are maintained by suppressing cell divisions. In this study, we suggested that IFNγis unable to maintain HSCs through the activation of energy metabolism while this cytokine suppresses HSC divisions. In addition, the appropriate suppression of energy metabolism contributes to HSC maintenance after cell divisions. Therefore, it is expected to clarified the mechanism how energy metabolism contributes to HSC divisions and the maintenance of stem-ness.

Academic Significance and Societal Importance of the Research Achievements

これまで、「造血幹細胞は維持するためには分裂をさせない」と考えられてきたが、本研究において、分裂抑制をしても幹細胞を維持出来ないメカニズム、さらには造血幹細胞が分裂後に幹細胞性を維持するメカニズムの一端を見出すことが出来た。これらの成果は、造血幹細胞の体外増幅技術の開発に大きく寄与し、骨髄移植を用いた遺伝子治療や再生医療の発展に大きく寄与すると考えられる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] CSI, National University of Singapore(Singapore)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Ca(2+)-mitochondria axis drives cell division in hematopoietic stem cells2018

    • Author(s)
      Umemoto T, Hashimoto M, MatsumuraT, Nakamura-Ishizu A, Suda T
    • Journal Title

      J Exp Med.

      Volume: 218(8) Issue: 8 Pages: 2097-2113

    • DOI

      10.1084/jem.20180421

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrin αvβ3 enhances the suppressive effect of interferon‐γ on hematopoietic stem cells2017

    • Author(s)
      Umemoto Terumasa、Matsuzaki Yu、Shiratsuchi Yoshiko、Hashimoto Michihiro、Yoshimoto Takayuki、Nakamura‐Ishizu Ayako、Petrich Brian、Yamato Masayuki、Suda Toshio
    • Journal Title

      The EMBO Journal

      Volume: 36 Issue: 16 Pages: 2390-2403

    • DOI

      10.15252/embj.201796771

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Ca2+-mitochondria pathway による造血幹細胞の分裂制御2018

    • Author(s)
      梅本 晃正、橋本倫拓、須田年生
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞内カルシウム-ミトコンドリア制御を介した造血幹細胞の分裂制御2018

    • Author(s)
      梅本 晃正、橋本倫拓、須田年生
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ca2+-Mitochondrial axis drives cell division in hematopoietic stem cells.2018

    • Author(s)
      Terumasa Umemoto, Michihiro Hashimoto, Toshio Suda.
    • Organizer
      第17回幹細胞シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mitochondria metabolism regulates the activation of hematopoietic stem cells2018

    • Author(s)
      Terumasa Umemoto, Michihiro Hashimoto, Toshio Suda
    • Organizer
      JSPS & NUS Joint 2nd symposium "New Horizons in Normal and Cancer Stem Cell Research"
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mitochondria metabolism regulates the activation of hematopoietic stem cells2017

    • Author(s)
      Terumasa Umemoto, Yu Matsuzaki, Michihiro Hashimoto, Toshio Suda
    • Organizer
      The 15th Stem Cell Research Symposium
    • Related Report
      2017 Research-status Report
  • [Presentation] Mitochondria metabolism regulates the activation of hematopoietic stem cells2017

    • Author(s)
      Terumasa Umemoto, Michihiro Hashimoto, Toshio Suda
    • Organizer
      The 46th ISEH annual scientific meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ミトコンドリア代謝変化による造血幹細胞の活性化制御機構2017

    • Author(s)
      梅本晃正、松崎優、橋本倫拓、須田年生
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ミトコンドリア代謝変化による造血幹細胞の活性化制御機構2017

    • Author(s)
      梅本晃正、橋本倫拓、須田年生
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2020-03-30  

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