The strategy for targeting Sp1 to eludicate CML cells

Research Project

Project/Area Number	17K16193
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hematology
Research Institution	Jichi Medical University
Principal Investigator	Koyama Daisuke 自治医科大学, 医学部, 客員研究員 (50741071)
Project Period (FY)	2017-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	慢性骨髄性白血病 / Sp1 / オートファジー / 血液内科 / トランスレーショナルリサーチ
Outline of Final Research Achievements	Chronic myeloid leukemia is a myeloproliferative neoplasm that driven by BCR-ABL tyrosine kinase. BCR-ABL is degraded by autophagy. It was clarified that Sp1 plays the crucial role for the expression of autophagy-related genes.
Academic Significance and Societal Importance of the Research Achievements	慢性骨髄性白血病を根治するための新規治療戦略を開発するための理論的基盤となる。

Report

(3 results)