The strategy for targeting Sp1 to eludicate CML cells
| Project/Area Number |
17K16193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Koyama Daisuke 自治医科大学, 医学部, 客員研究員 (50741071)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性骨髄性白血病 / Sp1 / オートファジー / 血液内科 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
Chronic myeloid leukemia is a myeloproliferative neoplasm that driven by BCR-ABL tyrosine kinase. BCR-ABL is degraded by autophagy. It was clarified that Sp1 plays the crucial role for the expression of autophagy-related genes.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性骨髄性白血病を根治するための新規治療戦略を開発するための理論的基盤となる。
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Eradication of central nervous system leukemia of T-cell origin with a brain-permeable LSD1 inhibitor.2019
Author(s)
Saito S, Kikuchi J, Koyama D, Sato S, Koyama H, Osada N, Kuroda Y, Akahane K, Inukai T, Umehara T, Furukawa Y.
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Journal Title
Clin Cancer Res
Volume: 25
Issue: 5
Pages: 1601-1611
DOI
Related Report
Peer Reviewed
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