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Development of hematopoietic stem cell products by using multiple cord blood units

Research Project

Project/Area Number 17K16194
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKitasato University

Principal Investigator

Ishida Takashi  北里大学, 医学部, 助教 (90596470)

Research Collaborator Suzuki Takahiro  北里大学, 医学部血液内科学, 教授 (40345210)
Miyazaki Koji  北里大学, 医学部輸血・細胞移植学, 教授 (90261966)
Takahashi Satoshi  東京大学医科学研究所, 先端医療研究センター 分子療法分野, 准教授 (60226834)
Otsu Makoto  東京大学医科学研究所, 幹細胞研究センター 幹細胞プロセシング分野, 准教授 (30361330)
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生着改善 / 複数臍帯血移植 / 幹細胞増幅 / 早期血球回復 / 好中球回復 / 血小板回復 / 造血幹細胞増幅 / 臍帯血移植の生着改善 / 造血幹細胞 / 臍帯血 / 造血幹細胞移植 / 移植・再生医療 / 内科 / 臨床 / 免疫学
Outline of Final Research Achievements

Because of the highly incidence of the delay of hematopoietic recovery in umbilical cord blood transplantation, treatment related complications are one of the important problems. The low cell dose within each umbilical cord blood unit should be one of the main causes for this clinical problem and limit the use of cord blood. We therefore sought to develop a novel therapeutic approach by using multiple cord blood units, eventually aiming at better transplantation outcomes.
In this research, we developed a novel method to extract viable hematopoietic stem/progenitor cells from multiple cord blood units at one time through a closed system. We also tested a potential of these cells by conducting in vitro colony assay. We observed colony formation of myeloid, erythroid and megakaryocyte progenitors, suggesting that cells collected by our strategy could potentially yield blood cells and shorten myelosuppression phase associated with cord blood transplantation.

Academic Significance and Societal Importance of the Research Achievements

本研究は、臍帯血移植後の造血、免疫再構築を促進する新規治療法の開発研究である。この研究成果により、含有細胞数不足の為にdead stockとなっていた大半の臍帯血を移植時の早期造血回復に活用することで、安全な移植医療の実現や臍帯血移植の適応拡大につながる可能性がある。特に血小板や好中球の早期回復は治療関連合併症の軽減に結び付く為、喫緊の課題である。さらに、本法により輸血や抗生剤、サイトカイン療法などの使用頻度が軽減されれば、医療経済効果も期待される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Characteristics of palliative home care for patients with hematological tumors compared to those of patients with solid tumors2019

    • Author(s)
      Ishida Takashi, Ohashi Kota, Okina Chikako, Ohashi Shiho, Okina Sosei, Miyazaki Koji and Suzuki Takahiro
    • Journal Title

      International Journal of Hematology

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The clinical outcomes of chronic myeloid leukemia patients harboring alternatively spliced BCR-ABL variants2018

    • Author(s)
      Ishida Takashi、Miyazaki Koji、Okina Sosei、Miyata Tomomi、Hayama Kei、Higashihara Masaaki、Suzuki Takahiro
    • Journal Title

      Hematology

      Volume: 24 Issue: 1 Pages: 49-51

    • DOI

      10.1080/10245332.2018.1507883

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characteristics of palliative home care for hematological tumors in comparison with solid tumors2018

    • Author(s)
      Ohashi Kota, Ishida Takashi, Okina Chikako, Ohashi Shiho, Okina Sosei, Miyazaki Koji and Suzuki Takahiro
    • Organizer
      第80回日本血液学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Expression of adhesion molecules in intravascular lymphoma: histopathological review of our cases2018

    • Author(s)
      Shinji Ogura,Masashi Akiya,Yuichi Horigome,Isao Yoshida, Sosei Okina,Noriyuki Tadera,Takashi Ishida,Yusuke Michishita, Maki Yokoyama,Hirotoshi Kamata,Koji Miyazaki,Yoshiki Murakumo, Takahiro Suzuki
    • Organizer
      第80回日本血液学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血液免疫難病の克服を目指す幹細胞研究2018

    • Author(s)
      大津真
    • Organizer
      第77回神奈川血液研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 複数臍帯血ユニット由来移植補助製剤の開発2017

    • Author(s)
      石田隆
    • Organizer
      第15回先端血液学セミナー
    • Related Report
      2017 Research-status Report
  • [Presentation] 複数臍帯血ユニット由来移植補助製剤の開発2017

    • Author(s)
      石田隆
    • Organizer
      第5回血液学アカデミー
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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