| Project/Area Number |
17K16204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
Kobayashi Satomi
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 全身性強皮症 / single cell RNA-seq / 単球 / 炎症 / シングルセルRNA-seq / 免疫細胞 |
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| Outline of Final Research Achievements |
Single cell RNA-seq analysis was performed on peripheral blood monocytes population of systemic sclerosis patients. Several clusters of monocytes were identified by the result. Integrated analysis with bulk monocyte data from systemic sclerosis patients suggested a subset of inflammatory monocytes have a role in the pathogenesis of systemic sclerosis.
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| Academic Significance and Societal Importance of the Research Achievements |
全身性強皮症の病態に単球が関わることがこれまでも報告されていたが、本研究によって全身性強皮症の病態に関わる可能性のある単球の一部の炎症性細胞集団が同定された。この細胞集団に特徴的に発現している遺伝子の情報は全身性強皮症の新規のバイオマーカーとして診断や患者の層別化に役立つ可能性、また新しい治療薬の開発に結びつく可能性があるものと考えられた。
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