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Single-cell RNA-seq analysis on immune cells of systemic sclerosis

Research Project

Project/Area Number 17K16204
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionThe University of Tokyo

Principal Investigator

Nagafuchi Yasuo  東京大学, 医学部附属病院, 助教 (20792279)

Research Collaborator Kobayashi Satomi  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords全身性強皮症 / single cell RNA-seq / 単球 / 炎症 / シングルセルRNA-seq / 免疫細胞
Outline of Final Research Achievements

Single cell RNA-seq analysis was performed on peripheral blood monocytes population of systemic sclerosis patients. Several clusters of monocytes were identified by the result. Integrated analysis with bulk monocyte data from systemic sclerosis patients suggested a subset of inflammatory monocytes have a role in the pathogenesis of systemic sclerosis.

Academic Significance and Societal Importance of the Research Achievements

全身性強皮症の病態に単球が関わることがこれまでも報告されていたが、本研究によって全身性強皮症の病態に関わる可能性のある単球の一部の炎症性細胞集団が同定された。この細胞集団に特徴的に発現している遺伝子の情報は全身性強皮症の新規のバイオマーカーとして診断や患者の層別化に役立つ可能性、また新しい治療薬の開発に結びつく可能性があるものと考えられた。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2019 2018

All Presentation (2 results)

  • [Presentation] Integrated bulk and single-cell RNA-sequencing identified disease relevant monocyte subset and key driver inflammatory gene module of systemic sclerosis2019

    • Author(s)
      Satomi Kobayashi , Yasuo Nagafuchi , Hirofumi Shoda , Mai Okubo , Yusuke Sugimori , Mineto Ohta , Yusuke Takeshima , Yukiko Iwasaki , Shuji Sumitomo , Tomohisa Okamura , Kazuhiko Yamamoto , Keishi Fujio
    • Organizer
      日本リウマチ学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 全身性強皮症の免疫細胞トランスクリプトームによる病態関連因子の探索2018

    • Author(s)
      小林 聖未(東京大学 大学院医学系研究科アレルギー・リウマチ内科), 永渕 泰雄, 庄田 宏文, 大久保 麻衣, 杉森 祐介, 白井 晴己, 波多野 裕明, 前田 淳子, 竹島 雄介, 太田 峰人, 岩崎 由希子, 住友 秀次, 岡村 僚久, 山本 一彦, 藤尾 圭志
    • Organizer
      日本臨床免疫学会総会
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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