| Project/Area Number |
17K16206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Research Collaborator |
NAKAO ATSUHITO
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アレルギー / マスト細胞 / 概日時計 / ストレス / 精神的ストレス / アナフィラキシーショック |
|---|
| Outline of Final Research Achievements |
This study shows that the mast cell clock mediates circadian regulation of plasma histamine levels at steady state, which can be modulated by psychological stress. This is due to, in part, by the control of organic cation transporter 3 (OCT3) expression in mast cells by the circadian clock. The findings provide a novel insight into the relationships among psychological stress, circadian clock, and allergic reaction.
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| Academic Significance and Societal Importance of the Research Achievements |
“こころ”と“アレルギー”の関係という21世紀に残された大きな謎の１つを解明する端緒となる研究成果であり、臨床的には、現代のストレス社会に生きるアレルギー患者の複雑な病態について理解を深める一助となる。
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