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Biological significance of IL-17 in host defense against Streptococcus pneumoniae infection

Research Project

Project/Area Number 17K16229
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Akahori Yukiko  国際医療福祉大学, 成田保健医療学部, 助教 (80782961)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
KeywordsIL-17 / 肺炎球菌 / 肺炎 / 感染症 / サイトカイン
Outline of Final Research Achievements

Interleukin-17 (IL-17) plays an essential role in host defense against pathogens. In the present study, we aimed to elucidate the role of IL-17A and IL-17F in host defense against Streptococcus pneumoniae (Sp) infection. We found that IL-17A-deficient mice were highly susceptible to Sp infection, whereas IL-17F-deficient mice showed increased resistance. Upon infection with Sp, lipocalin production was increased in IL-17A-deficient mice compared to WT mice, while the production was decreased in IL-17F-deficient mine. In Sp-infected mice, innate lymphoid cells and gdT cells were identified as the source of IL-17. These results suggest that IL-17A and IL-17F have distinct roles in host defense against Sp infection.

Academic Significance and Societal Importance of the Research Achievements

これまでの研究から肺炎球菌感染の臨床肺サンプルにおいて、IL-17Aの産生低下が肺炎球菌感染の重症化と相関していることや、病理知見においてIL-17A産生細胞の肺集積が認められていたが、IL-17の役割は不明であった。本研究により、IL-17AおよびIL-17Fの肺炎球菌肺炎における役割が明らかになった。興味深いことに、IL-17AとIL-17Fは逆の免疫作用をもつ。さらなるIL-17AおよびIL-17Fの機能解析を進めることで、肺炎球菌肺炎に対する新規治療法およびワクチン開発などにつながることが期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2021 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens2021

    • Author(s)
      Yabe Rikio、Chung Soo-Hyun、Murayama Masanori A.、Kubo Sachiko、Shimizu Kenji、Akahori Yukiko、Maruhashi Takumi、Seno Akimasa、Kaifu Tomonori、Saijo Shinobu、Iwakura Yoichiro
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 94-94

    • DOI

      10.1038/s41467-020-20307-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] C型レクチン受容体と感染制御2019

    • Author(s)
      赤堀ゆきこ、西城忍
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 72 Pages: 103-108

    • NAID

      40021959413

    • Related Report
      2019 Research-status Report
  • [Presentation] C型レクチン受容体Dectin-1による肺炎球菌の認識とその生体防御応答2018

    • Author(s)
      赤堀ゆきこ、矢部力朗、岩倉洋一郎、西城忍
    • Organizer
      第83回日本インターフェロン・サイトカイン学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Dectin-1/-2クラスターに存在するC型レクチン 受容体の病原真菌認識機構2018

    • Author(s)
      矢部力朗、小林睦月、赤堀ゆきこ、西城忍
    • Organizer
      第83回日本インターフェロン・サイトカイン学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 自然免疫センサーの真菌感染応答を制御する新たな仕組み2018

    • Author(s)
      矢部力朗、小林睦月、赤堀ゆきこ、西城忍
    • Organizer
      第3回グローバルプロミネント研究基幹シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] The innate immune DNA sensor STING controls cryptococcal meningitis2018

    • Author(s)
      Rikio Yabe, Mutsuki Kobayashi, Yukiko Akahori, Shinobu Saijo
    • Organizer
      The 7th Global Network Forum on Infection and Immunity
    • Related Report
      2018 Research-status Report
  • [Presentation] Streptococcus pneumoniaeに対する宿主認識と感染免疫応答機構の解明2017

    • Author(s)
      赤堀ゆきこ、矢部力朗、横山隣、河野弥季、長沢光章、西城忍
    • Organizer
      第66回日本医学検査学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Molecular mechanism of anti-pneumococcal immune responses by Dectin-12017

    • Author(s)
      Yukiko Akahori, Rikio Yabe, Yoichiro Iwakura, Shinobu Saijo
    • Organizer
      International Cytokine and Interferon Society 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dectin-1 mediates innate immune responses in Streptococcus pneumoniae infection2017

    • Author(s)
      Yukiko Akahori, Rikio Yabe, Yoichiro Iwakura, Shinobu Saijo
    • Organizer
      第46回日本免疫学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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