| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Monitoring of HHV-6B reactivation was carried out in hematopoietic cell transplant patients. The group was divided into four groups: HHV-6B reactivation group: 17 cases, skin GVHD group: 13 cases, HHV-6B reactivation and skin GVHD group: 11 cases and control group which were not recognized both HHV-6B reactivation and skin GVHD: 18 cases. Eleven kinds of cytokines and chemokines were measured from serum that collected from patients at 1, 2, 3, 4 and 6 weeks after hematopoietic cell transplantation.
In HHV-6B reactivation group, IL-2, 4, 6, 10 at week 2, IL-10, IP-10 at week 3, IP-10, TNF-α at week 6 were significantly increased compared to the control group. In skin GVHD group, IL-4, 17 at week 2, IL-4, 10, IP-10 at week 3, and IL-10, 17 at week 6 were significantly increased compared to the control group.
Rader charts showed that the figures on the 1st and 2nd weeks were similar in the A and B groups, but the figures on the 3rd, 4th and 6th weeks were different between these groups.
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