The relationship between autism spectrum disorder and neonatal jaundice
| Project/Area Number |
17K16299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | autism spectrum disorder / UGT1A1 / neonatal jaundice / developmental disorder / dried umbilical cord / 自閉スペクトラム症 / autism spectrum syndrome / 遺伝子 / 臨床 |
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| Outline of Final Research Achievements |
To elucidate the role in the development of autism spectrum disorders (ASD), this study investigated the incidence of UDP-glucuronosyltransferase (UGT1A1) gene polymorphisms associated with neonatal jaundice in the population of ASD children and Japan. We compared it with the general frequency of humans and examined whether it was involved in the development of ASD.
As a result of analyzing the DNA, the frequency of UGT1A1＊6 and UGT1A1*28 gene polymorphisms was the same as the general frequency of Japanese people, and at least the UGT1A1 gene polymorphism, which is one of the risks of developing neonatal jaundice in the onset of ASD was not considered to be involved.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究でASD発症におけるリスク因子としてUGT1A1遺伝子多型の有無が明らかになれば、新生児黄疸のなりやすさを評価することによって新生児黄疸の管理を適切に行うことが可能となり、ASDの発症予防につながることが期待できたが、UGT1A1遺伝子多型はASDの発症に関与していない事が明らかとなった。
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Report
(6 results)
Research Products
(18 results)
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[Journal Article] Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis2018
Author(s)
Maeyama K, Tomioka K, Nagase H, Yoshioka M, Takagi Y, Kato T, Mizobuchi M, Kitayama S, Takada S, Nagai M, Sakakibara N, Nishiyama M, Taniguchi-Ikeda M, Morioka I, Iijima K, Nishimura N
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Journal Title
Jornal of Autism Development Disorder
Volume: 48
Pages: 1483-1491
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation index for asymmetric ventricular size on brain magnetic resonance images in very low birth weight infants2018
Author(s)
Ikuta T, Mizobuchi M, Katayama Y, Yoshimoto S, Ioroi T, Yamane M, Morisawa T, Takatera A, Ueda M, Shibata A, Maeyama K, Mandai T, Fujioka K, Nishimura N, Iijima K, Morioka I.
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Journal Title
Brain Devopment
Volume: 40
Pages: 753-759
Related Report
Peer Reviewed / Open Access
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[Presentation] UGT1A1*6 and *28 as factors associated with prolonged hyperbilirubinemia in Japanese preterm infants2018
Author(s)
Yamana K, Iwatani S, Fukushima S, Ikuta T, Ashina M, Ohyama S, Okubo S, Maeyama K, Fujioka K, Iijima K, Morioka I.
Organizer
Pediatric Academic Society Annual Meeting,Toronto,Canada
Related Report
Int'l Joint Research
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[Presentation] Comparison between the incidence of short stature in term SGA and late-preterm AGA infants: A matched case-control study2018
Author(s)
Fukushima S, Maeyama K,Mastumoto M,Ashina M, Ikuta T, Okubo S,Oyama S,Yamana K,Fujioka K, Awano H,Mishina H,Iijima K,Morioka I.
Organizer
Pediatric Academic Society Annual Meeting,Toronto,Canada
Related Report
Int'l Joint Research
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[Presentation] Is congenital cytomegalovirus infection associated with autism spectrum disorder?2018
Author(s)
Nishimura N, Maeyama K, Tomioka K, Nagase H, Yoshioka M, Takagi Y, Kato T, Mizobuchi M, Kitayama S, Takada S, Nagai M, Sakakibara N, Nishiyama M, Morioka I, Iijima K
Organizer
第60回日本小児神経学会
Related Report
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