Association of intrauterine growth restriction with vasculopathy

• Project/Area Number: 17K16300
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kyushu University
• Principal Investigator: Inoue Hirosuke 九州大学, 大学病院, 助教 (90467902)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 子宮内発育遅延 / 低出生体重児 / 血管病変 / 血管炎 / SGA児 / IUGR / 自然免疫 / 胎児医学 / 胎児子宮内発育遅延

Outline of Final Research Achievements

We measured and compared various pro-inflammatory cytokines and serological markers of vasculitis in 87 newborn infants (28 IUGR and 59 non-IUGR infants) admitted to our NICU. Although no pro-inflammatory cytokines or serological markers of vasculitis were significantly higher in IUGR than non-IUGR infants, the gestational age was significantly younger in non-IUGR infants than in IUGR infants, suggesting the presence of effects of inflammation associated with preterm birth. ICAM-1 (median: 130 ng/mL in IUGR, 104 ng/mL in non-IUGR) and VCAM-1 (2009 ng/mL in IUGR, 1995 ng/mL in non-IUGR) tended to be higher in IUGR than non-IUGR infants, indicating the presence of vascular lesions in IUGR infants.

Academic Significance and Societal Importance of the Research Achievements

低出生体重児は全出生のおよそ10％で、近年増加傾向である。低出生体重児の健康問題は重要な公衆衛生課題である。子宮内発育遅延は低出生体重児の重要な原因の1つで、将来的な動脈硬化など生活習慣病との関連が示唆されている。本研究では子宮内発育遅延児の血管病変について調査し、新生児期から血管病変が存在することが示唆された。血管病変に対し新生児期から介入できれば、近年増加傾向にある低出生体重児の将来の健康に寄与できる可能性がある。

Research Products

• [Journal Article] Trends in Bronchopulmonary Dysplasia Among Extremely Preterm Infants in Japan, 2003-2016 (2021)
  • Author(s): Nakashima Toshinori、Inoue Hirosuke、Sakemi Yoshihiro、Ochiai Masayuki、Yamashita Hironori、Ohga Shouichi
  • Journal Title: The Journal of Pediatrics Volume: 230 Pages: 119-125.e7
  • DOI: 10.1016/j.jpeds.2020.11.041
  • Peer Reviewed
• [Journal Article] Transcutaneous blood gas monitoring among neonatal intensive care units in Japan (2020)
  • Author(s): Ochiai M, Kurata H, Inoue H, Ichiyama M, Fujiyoshi J, Watabe S, Hiroma T, Nakamura T, Ohga S.
  • Journal Title: Pediatr Int Volume: 2 Issue: 2 Pages: 169-174
  • DOI: 10.1111/ped.14107
  • Peer Reviewed
• [Journal Article] Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia (2019)
  • Author(s): Kurata Hiroaki、Ochiai Masayuki、Inoue Hirosuke、Kusuda Takeshi、Fujiyoshi Junko、Ichiyama Masako、Wakata Yoshifumi、Takada Hidetoshi
  • Journal Title: Pediatrics & Neonatology Volume: 60 Issue: 5 Pages: 496-503
  • DOI: 10.1016/j.pedneo.2018.11.007
  • Peer Reviewed / Open Access
• [Journal Article] Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis. (2018)
  • Author(s): Kinjo T, Inoue H, Kusuda T, Fujiyoshi J, Ochiai M, Takahata Y, Honjo S, Koga Y, Hara T, Ohga S
  • Journal Title: Pediatr Neonatol. Volume: 54 Issue: 4 Pages: 53-60
  • DOI: 10.1016/j.pedneo.2018.09.005
  • Peer Reviewed
• [Journal Article] Neurodevelopmental Outcomes in Infants With Birth Weight ≦500 g at 3 Years of Age. (2018)
  • Author(s): Inoue H, Ochiai M, Sakai Y, Yasuoka K, Tanaka K, Ichiyama M, Kurata H, Fujiyoshi J, Matsushita Y, Honjo S, Nonaka K, Taguchi T, Kato K, Ohga S; Neonatal Research Network of Japan.
  • Journal Title: Pediatrics. Volume: 142 Issue: 6
  • DOI: 10.1542/peds.2017-4286
  • Peer Reviewed