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Analysis of the mechanism of erythema formation via IgE autoantibodies in bullous pemphigoid

Research Project

Project/Area Number 17K16318
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

IZUMI Kentaro  北海道大学, 医学研究院, 助教 (50793668)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords皮膚病態学 / 自己免疫 / 水疱症 / 水疱性類天疱瘡 / 基底膜タンパク / 免疫学 / 蛋白質 / 酵素
Outline of Final Research Achievements

Bullous pemphigoid (BP) is clinically characterized by blisters and erythema with pruritis. We found that basophils were activated in the peripheral blood from BP patients. It was suggested that basophil activation was based on the binding of type XVII collagen and BP-IgE autoantibody. Although type XVII collagen express along the basement membrane zone of epidermis under the steady state, we found that type XVII collagen was also localized in the superficial dermis in the lesional skin from a part of BP patients.

Academic Significance and Societal Importance of the Research Achievements

本研究にて水疱性類天疱瘡(BP)の血中好塩基球の活性化が17型コラーゲン-IgE自己抗体の結合に基づいて生じた可能性が示唆された。好塩基球の活性化は脱顆粒に引き続いて起こるケミカル・メディエーターの放出を介して血管透過性の亢進や皮膚炎症を惹起することから、17型コラーゲンとBP-IgE自己抗体の抗原-抗体反応がBPの病態に関与している可能性が考えられた。未だ、ステロイドの全身投与が治療の第一選択であるBPにおいてBP-IgE自己抗体を介した好塩基球の活性化がBPの新規治療法に繋がる可能性が示唆された。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Detection of mucous membrane pemphigoid autoantibodies by full-length BP180 enzyme-linked immunosorbent assay2017

    • Author(s)
      Izumi Kentaro、Nishie Wataru、Mai Yosuke、Ujiie Hideyuki、Iwata Hiroaki、Natsuga Ken、Shimizu Hiroshi
    • Journal Title

      J Dermatol Sci

      Volume: 88 Issue: 2 Pages: 247-248

    • DOI

      10.1016/j.jdermsci.2017.07.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid2017

    • Author(s)
      Kentaro Izumi, Wataru Nishie, Yosuke Mai, Mayumi Wada, Ken Natsuga, Hideyuki Ujiie, Hiroaki Iwata, Jun Yamagami, Hiroshi Shimizu
    • Organizer
      The 42nd annual meeting of the Japanese society for investigative dermatology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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