Development of a novel mouse model of psoriasis and elucidation of its pathogenic mechanism
| Project/Area Number |
17K16321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Akita University |
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Principal Investigator |
Noto Mai 秋田大学, 医学部附属病院, 助教 (10738462)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 尋常性乾癬 / Vps34 / オートファジー / イノシトールリン脂質代謝 / Sox13 / 転写因子 / 毛包幹細胞 / メンブレントラフィック / Sox / 毛包 / 幹細胞 / エンドサイトーシス / VPS34 / 遺伝子改変マウス / PI3キナーゼ |
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| Outline of Final Research Achievements |
Abnormalities in autophagy have been shown to be involved in the pathogenesis of a variety of diseases. We have found that Vsp34 (a class III PI3-kinase)-deficient mouse epidermis developed lesions similar to those in psoriasis vulgaris. In psoriasis, the epidermis is abnormally thickened, suggesting a relationship with stem cells. As part of our stem cell research,we have also found that the transcription factor Sox13 could serve as a novel marker for hair follicle stem cells.
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| Academic Significance and Societal Importance of the Research Achievements |
食事の西洋化に伴い、わが国では尋常性乾癬の患者が増加し、メタボリック症候群との関連も注目されている。本研究で私たちが作製した、表皮特異的なVsp34欠損を基盤とする新しい乾癬モデルは、乾癬発症におけるオートファジーの役割の解明につながる可能性がある。また、Sox13は、新しい毛包幹細胞マーカーとして、幹細胞研究の発展に寄与すると考えられる。
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Report
(4 results)
Research Products
(6 results)
