| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
Autosomal dominant woolly hair and hypotrichosis (ADWH/H) are caused by mutations in the Keratin71 gene. However, the pathomechanism remains still unclear.
The purpose of this study is to clarify the effect of a novel mutation of karatin71 (Krt71) obtained from a mouse exhibiting woolly hair on the morphology of hair follicles. By immunofluorescence double staining, cultured cells introduced with mutant Krt71 did not form keratin intermediate filaments (KIFs) and aggregated around the nucleus. The mutant keratin71 was considered to have some influence on the dimer formation with endogenous type I keratin in cultured cells. These results suggest that the abnormal morphology of the hair follicle epithelium caused by the Krt71 mutation is important for the development of woolly hair.
|
