| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This study was enrolled 7 patients diagnosed at Japanese spotted fever (JSF) under the obtained enough informed consent. The 7 patients was proved at JSF by peformed the PCR test from blood and/or skin or acute stage IgM>80 against anti-R.japonica antibody or IgM and/or IgG more than 4 times between acute and recovery stage.
We messured any cytokines: IFN-γ, TNF-α, TNF-β, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12p70, IL-17A, IL-17F, IL-22, IL-33, GM-CSF, TSLP at the first visit (acute stage) and 14days after treatment (recovery stage).
Case 1,2,3 were measured at 4 points: 1, 3, 7, 14 day. The cytokines were tested by flow cytometric analyses using AimPlex. And We also compeared the asossiation of WBC, Eosin and CRP.
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