| Project/Area Number |
17K16340
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kobe University |
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Principal Investigator |
Ogura Kanako 神戸大学, 医学研究科, 医学研究員 (70619155)
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| Research Collaborator |
Fukunaga Atsushi
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 食物依存性運動誘発アナフィラキシー / ミソプロストール / アスピリン蕁麻疹 / アレルギー |
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| Outline of Final Research Achievements |
We analyzed premedication of mysoprostol, which is one of the PGE1 derivative, was effective in managing food-dependent exercise induced anaphylaxis (FEIAn). Thirty-two patients were suspected FEIAn due to interviews and positive specific IgE and/ or prick test positive. Of these, diagnosis was confirmed by challenge tests in twenty-nine subjects and twenty-three were rechallenged under the premedication of mysoprostol. As a result, twenty out of twenty-three subjects (87%) had no reactions after challenge test. For the patients having FEIAn, misoprostol can be a preventive tool and improve their quality of life.
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| Academic Significance and Societal Importance of the Research Achievements |
食物依存性運動誘発アナフィラキシーの原因食物は小麦が最多であり、症状誘発の閾値が体調や運動、NSAID内服により変動する。症状誘発をなくすためには摂取しないことが必要となるが、日常生活で小麦を完全に回避することは難しく、誤食により症状が誘発される危険性も高い。外食時など事前に摂取する可能性が高いことが予測される場合に、症状を抑制できる薬剤があれば患者のADL向上につながると思われる。
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