| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
(1)In the keratinocyte-specific TRAF6-deficient mice, the mBD14 expression level in the steady state was decreased as compared with that in the Langerhans cell-specific TRAF6-deficient mice. This result suggests the importance of keratinocyte TRAF6 in the expression of mBD14 levels in epidermis in steady-state.
(2)The S. aureus-induced upregulation of mBD14 mRNA expression was maintained in Langerhans cell-specific TRAF6-deficient mice, but was suppressed in keratinocyte-specific TRAF6-deficient mice. This result suggests the importance of TRAF6 in keratinocytes but not Langerhans cells in induction of mBD14 expression in response to transcutaneous invasion of S. aureus. However, it was found that more reliable experimental system should be conducted to conclude the result.
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