Development of a new topical agent for psoriasis vulgaris.

• Project/Area Number: 17K16355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Aichi Medical University
• Principal Investigator: Hiroyuki Takama 愛知医科大学, 医学部, 講師 (80780965)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: EGFR / 乾癬 / ケラチノサイト / 尋常性乾癬 / aplasia cutis congenita / Pazopanib / PNPLA1 / SDR9C7 / 表皮成長因子阻害剤 / 皮膚疾患

Outline of Final Research Achievements

We reported on the role of keratinization of disease-specific genes in skin diseases and their treatment. We reported that the NIPAL4 gene is involved in the metabolism of acylceramide in the stratum corneum and that IL-17 and IL-36 are involved in the pathophysiology of the mutation. We reported two cases of nail psoriasis, who were successfully treated with corticosteroid and vitamin D3 analogue in topical gel formulation.

Academic Significance and Societal Importance of the Research Achievements

角化症やその他の皮膚疾患の病態解明、新たな治療法の解明などにつながる臨床症例経験や、遺伝子関連疾患の皮膚での役割を報告することができた。

Research Products

• [Journal Article] Two cases of refractory nail psoriasis successfully treated with calcipotriol plus betamethasone dipropionate gel. (2020)
  • Author(s): Takama H, Ando Y, Yanagishita T, Ohshima Y, Akiyama M, Watanabe D.
  • Journal Title: J Dermatol Volume: epub Issue: 5
  • DOI: 10.1111/1346-8138.15314
  • Peer Reviewed
• [Journal Article] Reduced stratum corneum acylceramides in autosomal recessive congenital ichthyosis with a NIPAL4 mutation. (2019)
  • Author(s): Murase Y, Takeichi T, Kawamoto A, Tanahashi K, Okuno Y, Takama H, Shimizu E, Ishikawa J, Ogi T, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: epub
  • Peer Reviewed
• [Journal Article] Urticarial vasculitis and subcutaneous nodules in the extremities seen in a patient with mucopolysaccharidosis II after hematopoietic stem cell therapy (2018)
  • Author(s): Shibata Akitaka、Yoshikawa Takenori、Makita Sumiko、Takama Hiroyuki、Arakawa Takeshi、Akiyama Masashi
  • Journal Title: The Journal of Dermatology Volume: 46 Issue: 2
  • DOI: 10.1111/1346-8138.14585
  • NAID: 120006643318
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitor-associated Bullous Pemphigoid: Recurrence with Epitope Spreading (2018)
  • Author(s): Takama H、Yoshida M、Izumi K、Yanagishita T、Muto J、Ohshima Y、Nishie W、Shimizu H、Akiyama M、Watanabe D
  • Journal Title: Acta Dermato Venereologica Volume: 98 Issue: 10 Pages: 983-984
  • DOI: 10.2340/00015555-3010
  • Peer Reviewed
• [Journal Article] Case of psoriatic erythroderma induced by the discontinuation of the chronic use of topical steroid after dialysis initiation and successfully treated with secukinumab (2018)
  • Author(s): Shibata Tomoyuki、Muto Jun、Takama Hiroyuki、Yanagishita Takeshi、Ito Tatsuo、Watanabe Daisuke
  • Journal Title: The Journal of Dermatology Volume: 46 Issue: 4
  • DOI: 10.1111/1346-8138.14649
  • Peer Reviewed
• [Journal Article] Indeterminate dendritic cell neoplasm accompanied by eosinophilic pneumonia successfully treated by systemic steroid therapy: Report of the first case with muscular and parotid involvement and review of published work (2018)
  • Author(s): Kiyohara Takahiro、Nakamaru Sei、Miyamoto Mari、Shijimaya Takako、Nagano Naoko、Makimura Kaoru、Takama Hiroyuki、Akiyama Masashi、Tanimura Hirotsugu
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 12 Pages: 1444-1447
  • DOI: 10.1111/1346-8138.14673
  • Peer Reviewed
• [Journal Article] Granulomatous pigmented purpuric dermatosis containing Propionibacterium acnes (2018)
  • Author(s): Takama H, Yanagishista T, Muto J, Ohshima Y, Takahashi E, Tsuzuki T, Uchida K, Eishi Y, Akiyama M, Watanabe D
  • Journal Title: European Journal of Dermatology Volume: 28 Issue: 4 Pages: 540-542
  • DOI: 10.1684/ejd.2018.3329
  • Peer Reviewed
• [Journal Article] CD1a-positive cutaneous mastocytosis: Electron microscopic evidence of pleomorphic mast cell proliferation. (2018)
  • Author(s): KIyohara T, Nagano N, Terai S, Nakamaru S, Makimura K, Takama H, Akiyama M, Tanimura H.
  • Journal Title: J Dermatol. Volume: 45 Issue: 4
  • DOI: 10.1111/1346-8138.14113
  • Peer Reviewed
• [Journal Article] Cytomegalovirus reactivation accompanied by varicella zoster virus reactivation or reinfection in an adult patient of multiple myeloma during bortezomib therapy. (2018)
  • Author(s): Hioki T, Takama H, Makita S, Watanabe K, Watanabe D, Akiyama M.
  • Journal Title: J Dermatol. Volume: 45 Issue: 1 Pages: 108-109
  • DOI: 10.1111/1346-8138.13744
  • Peer Reviewed
• [Journal Article] Eosinophilic annular erythema localized on the neck. (2017)
  • Author(s): Hioki T, Takama H, Makita S, Shibata A, Akiyama M, Watanabe D.
  • Journal Title: Eur J Dermatol. Volume: 27 Issue: 6 Pages: 673-674
  • DOI: 10.1684/ejd.2017.3145
  • Peer Reviewed
• [Journal Article] Leg ulcers associated with cutaneous vascular degeneration in a patient receiving pazopanib chemotherapy. (2017)
  • Author(s): Hioki T, Takama H, Makita S, Chen KR, Watanabe D, Akiyama M.
  • Journal Title: Eur J Dermatol. Volume: 27 Issue: 5 Pages: 546-547
  • DOI: 10.1684/ejd.2017.3092
  • Peer Reviewed
• [Journal Article] PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. (2017)
  • Author(s): Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash A, Ikeda K, Arita M, Akiyama M, Murakami M.
  • Journal Title: Nat Commun Volume: 8 Issue: 1 Pages: 14609-14609
  • DOI: 10.1038/ncomms14609
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deficient stratum corneum intercellular lipid in a Japanese patient with lamellar ichthyosis by a homozygous deletion mutation in SDR9C7. (2017)
  • Author(s): Takeichi T, Nomura T, Takama H, Kono M, Sugiura K, Watanabe D, Shimizu H, Simpson MA, McGrath JA, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 印刷中 Issue: 3
  • DOI: 10.1111/bjd.15315
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Infant bald patch: ultrasonographic diagnosis of aplasia cutis congenita. (2017)
  • Author(s): Hioki T, Takama H, Makita S, Akiyama M.
  • Journal Title: Eur J Dermatol. Volume: 31 Issue: 6
  • DOI: 10.1111/jdv.14018
  • Peer Reviewed