Examination of the relationship between the maternal mental health, and the development and behavior of children, and the psychosocial factors that affect them

• Project/Area Number: 17K16375
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyushu University (2021); Nagoya University (2017-2020)
• Principal Investigator: MORIKAWA MAKO 九州大学, 医学研究院, 共同研究員 (60783305)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 周産期 / 抑うつ状態 / ボンディング障害 / ソーシャルサポート / 母児相互作用 / 抑うつ / リスクファクター / 被養育体験 / うつ病既往 / 希死念慮 / 初産婦 / 経産婦 / 母児 / 生物学的 / 躁状態 / 心理社会的要因 / 愛着障害 / 医療・福祉

Outline of Final Research Achievements

In this study, we investigated the problem of attachment formation from mothers to children, which has been pointed out to be involved in child-rearing functions, so-called bonding disorders. Factors related to this revealed maternal depression.
Furthermore, we examined three factors including "poor social support", which is a confounding factor between the two. As a result, both the “number of donors” and “satisfaction” of perinatal social support subjectively perceived by perinatal women are protective against postpartum bonding disorders and depression.

Academic Significance and Societal Importance of the Research Achievements

本研究で検討した周産期女性の精神的健康やボンディング障害は、近年社会的な問題となっている虐待や自死と関連することが明らかとなっており、これらの危険因子や保護因子を検討したことで、周産期女性に対するケアや予防的対応法の一部が明らかとなったことは社会的意義として大きいと考える。さらに、これらを検証する際に使用する評価尺度の信頼性妥当性の検討も行っており、今後の研究利用において学術的意義も大きいと考える。

Research Products

• [Journal Article] Perceived Social Support Partially Mediates the Impact of Temperament and Character on Postpartum Depression. (2022)
  • Author(s): Nakamura Y, Takahashi N, Yamauchi A, Morikawa M, Okada T, Ozaki N.
  • Journal Title: Frontiers in Psyciatry Volume: 12 Pages: 816342-816342
  • DOI: 10.3389/fpsyt.2021.816342
  • Peer Reviewed / Open Access
• [Journal Article] Validation and factor analysis of the parental bonding instrument in Japanese pregnant women. (2021)
  • Author(s): Sato Maya, Okada Takashi, Morikawa Mako, Nakamura Yukako, Yamauchi Aya, Ando Masahiko, Ozaki Norio.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 13759-13759
  • DOI: 10.1038/s41598-021-93146-3
  • Peer Reviewed / Open Access
• [Journal Article] The Risk Factors Predicting Suicidal Ideation Among Perinatal Women in Japan (2020)
  • Author(s): Kubota Chika、Inada Toshiya、Shiino Tomoko、Ando Masahiko、Sato Maya、Nakamura Yukako、Yamauchi Aya、Morikawa Mako、Okada Takashi、Ohara Masako、Aleksic Branko、Murase Satomi、Goto Setsuko、Kanai Atsuko、Ozaki Norio
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 441-441
  • DOI: 10.3389/fpsyt.2020.00441
  • Peer Reviewed / Open Access
• [Journal Article] Validation and factor structure of the Japanese version of the inventory to diagnose depression, lifetime version for pregnant women (2020)
  • Author(s): Kubota Chika、Inada Toshiya、Nakamura Yukako、Shiino Tomoko、Ando Masahiko、Aleksic Branko、Yamauchi Aya、Morikawa Mako、Okada Takashi、Ohara Masako、Sato Maya、Murase Satomi、Goto Setsuko、Kanai Atsuko、Ozaki Norio
  • Journal Title: PLOS ONE Volume: 15 Issue: 6 Pages: e0234240-e0234240
  • DOI: 10.1371/journal.pone.0234240
  • Peer Reviewed / Open Access
• [Journal Article] Perinatal depression and anxiety of primipara is higher than that of multipara in Japanese women (2020)
  • Author(s): Nakamura Yukako、Okada Takashi、Morikawa Mako、Yamauchi Aya、Sato Maya、Ando Masahiko、Ozaki Norio
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 17060-17060
  • DOI: 10.1038/s41598-020-74088-8
  • Peer Reviewed
• [Journal Article] Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms (2019)
  • Author(s): Teshigawara Tomoaki、Mouri Akihiro、Kubo Hisako、Nakamura Yukako、Shiino Tomoko、Okada Takashi、Morikawa Mako、Nabeshima Toshitaka、Ozaki Norio、Yamamoto Yasuko、Saito Kuniaki
  • Journal Title: Journal of Affective Disorders Volume: 255 Pages: 168-176
  • DOI: 10.1016/j.jad.2019.05.028
  • Peer Reviewed
• [Journal Article] Methylation analysis for postpartum depression : a case control study. (2019)
  • Author(s): Nakamura Y, Nakatochi M, Kunimoto S, Okada T, Aleksic B, Toyama M, Shiino T, Morikawa M, Yamauchi A, Yoshimi A, Furukawa-Hibi Y, Nagai T, Ohara M, Kubota C, Yamada K, Ando M, Ozaki N.
  • Journal Title: BMC Psychiatry. Volume: 19 Issue: 1 Pages: 190-199
  • DOI: 10.1186/s12888-019-2172-x
  • Peer Reviewed / Open Access
• [Journal Article] Relation Between Perinatal Depressive Symptoms, Harm Avoidance, and a History of Major Depressive Disorder: A Cohort Study of Pregnant Women in Japan (2019)
  • Author(s): Kubota Chika、Inada Toshiya、Shiino Tomoko、Ando Masahiko、Aleksic Branko、Yamauchi Aya、Sato Maya、Ohara Masako、Murase Satomi、Morikawa Mako、Nakamura Yukako、Okada Takashi、Goto Setsuko、Kanai Atsuko、Ozaki Norio
  • Journal Title: Frontiers in Psychiatry Volume: 10 Pages: 515-515
  • DOI: 10.3389/fpsyt.2019.00515
  • Peer Reviewed / Open Access
• [Journal Article] Impact of perceived rearing and social support on bonding failure and depression among mothers: A longitudinal study of pregnant women. (2018)
  • Author(s): Ohara M, Nakatochi M, Okada T, Aleksic B, Nakamura Y, Shiino T, Yamauchi A, Kubota C, Morikawa M, Murase S, Goto S, Kanai A, Kato R, Ando M, Ozaki N.
  • Journal Title: J Psychiatr Res. Volume: 105 Pages: 71-77
  • DOI: 10.1016/j.jpsychires.2018.09.001
  • Peer Reviewed
• [Journal Article] Validation and Factor Analysis of the Japanese Version of the Highs Scale in Perinatal Women. (2018)
  • Author(s): Yamauchi A, Okada T, Ando M, Morikawa M, Nakamura Y, Kubota C, Ohara M, Murase S, Goto S, Kanai A, Ozaki N.
  • Journal Title: Front Psychiatry. Volume: 28
  • DOI: 10.3389/fpsyt.2018.00269
  • Peer Reviewed / Open Access
• [Journal Article] Stable factor structure of the Edinburgh Postnatal Depression Scale during the whole peripartum period: Results from a Japanese prospective cohort study. (2018)
  • Author(s): Kubota C, Inada T, Nakamura Y, Shiino T, Ando M, Aleksic B, Yamauchi A, Morikawa M, Okada T, Ohara M, Sato M, Murase S, Goto S, Kanai A, Ozaki N.
  • Journal Title: Sci Rep. Volume: 5 Issue: 1
  • DOI: 10.1038/s41598-018-36101-z
  • Peer Reviewed / Open Access
• [Journal Article] Postpartum depression among women in Nagoya indirectly exposed to the Great East Japan Earthquake. (2018)
  • Author(s): Kubota C, Okada T, Morikawa M, Nakamura Y, Yamauchi A, Ando M, Shiino T, Ohara M, Murase S, Goto S, Kanai A, Masuda T, Aleksic B, Ozaki N.
  • Journal Title: Sci Rep. Volume: 2 Issue: 1
  • DOI: 10.1038/s41598-018-30065-w
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between maternal depression and bonding failure: A prospective cohort study of pregnant women (2017)
  • Author(s): Ohara Masako、Okada Takashi、Kubota Chika、Nakamura Yukako、Shiino Tomoko、Aleksic Branko、Morikawa Mako、Yamauchi Aya、Uno Yota、Murase Satomi、Goto Setsuko、Kanai Atsuko、Masuda Tomoko、Ando Masahiko、Ozaki Norio
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 71 Issue: 10 Pages: 733-741
  • DOI: 10.1111/pcn.12541
  • Peer Reviewed
• [Journal Article] Social support helps protect against perinatal bonding failure and depression among mothers: a prospective cohort study (2017)
  • Author(s): Ohara Masako、Okada Takashi、Aleksic Branko、Morikawa Mako、Kubota Chika、Nakamura Yukako、Shiino Tomoko、Yamauchi Aya、Uno Yota、Murase Satomi、Goto Setsuko、Kanai Atsuko、Masuda Tomoko、Nakatochi Masahiro、Ando Masahiko、Ozaki Norio
  • Journal Title: Scientific Reports Volume: 7 Issue: 1
  • DOI: 10.1038/s41598-017-08768-3
  • Peer Reviewed / Open Access
• [Presentation] 母親のわが子に対する情緒的な絆と損害回避・抑うつ状態・ソーシャルサポートとの関係 (2017)
  • Author(s): 中村由嘉子、久保田智香、椎野智子、山内彩、大原聖子、森川真子、岡田俊、尾崎紀夫
  • Organizer: 第14回日本うつ病学会総会、第17回日本認知療法・認知行動療法学会
• [Presentation] 周産期女性のソーシャルサポートがボンディング障害・抑うつ状態に与える影響 (2017)
  • Author(s): 大原聖子、森川真子、久保田智香、中村由嘉子、椎野智子、山内彩、宇野洋太、岡田俊、尾崎紀夫
  • Organizer: 第113回日本精神神経学会総会